Delayed Density-Dependent Prevalence of Sin Nombre Virus Antibody in Montana Deer Mice ( Peromyscus maniculatus) and Implications for Human Disease Risk

2007 ◽  
Vol 7 (3) ◽  
pp. 353-364 ◽  
Author(s):  
Nita K. Madhav ◽  
Kent D. Wagoner ◽  
Richard J. Douglass ◽  
James N. Mills
Keyword(s):  
Human Disease ◽  
Peromyscus Maniculatus ◽  
Disease Risk ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Antibody ◽  
Density Dependent

scholarly journals RELATIONSHIP OF ECOLOGICAL VARIABLES TO SIN NOMBRE VIRUS ANTIBODY SEROPREVALENCE IN POPULATIONS OF DEER MICE

2000 ◽  
Vol 81 (3) ◽  
pp. 676-682 ◽  
Author(s):  
James R. Biggs ◽  
Kathy D. Bennett ◽  
Mary A. Mullen ◽  
Timothy K. Haarmann ◽  
Mary Salisbury ◽  
...  
Keyword(s):  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Antibody ◽  
Ecological Variables ◽  
Relationship Of

scholarly journals Development and Characterization of a Sin Nombre Virus Transmission Model in Peromyscus maniculatus

Viruses ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 183 ◽  
Author(s):  
Bryce Warner ◽  
Derek Stein ◽  
Bryan Griffin ◽  
Kevin Tierney ◽  
Anders Leung ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mouse ◽  
Virus Transmission ◽  
Transmission Model ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Infection Model ◽  
Main Driver ◽  
Heat Shock Responses

In North America, Sin Nombre virus (SNV) is the main cause of hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with a fatality rate of 35–40%. SNV is a zoonotic pathogen carried by deer mice (Peromyscus maniculatus), and few studies have been performed examining its transmission in deer mouse populations. Studying SNV and other hantaviruses can be difficult due to the need to propagate the virus in vivo for subsequent experiments. We show that when compared with standard intramuscular infection, the intraperitoneal infection of deer mice can be as effective in producing SNV stocks with a high viral RNA copy number, and this method of infection provides a more reproducible infection model. Furthermore, the age and sex of the infected deer mice have little effect on viral replication and shedding. We also describe a reliable model of direct experimental SNV transmission. We examined the transmission of SNV between deer mice and found that direct contact between deer mice is the main driver of SNV transmission rather than exposure to contaminated excreta/secreta, which is thought to be the main driver of transmission of the virus to humans. Furthermore, increases in heat shock responses or testosterone levels in SNV-infected deer mice do not increase the replication, shedding, or rate of transmission. Here, we have demonstrated a model for the transmission of SNV between deer mice, the natural rodent reservoir for the virus. The use of this model will have important implications for further examining SNV transmission and in developing strategies for the prevention of SNV infection in deer mouse populations.

scholarly journals Development of an ELISA to detect Sin Nombre virus-specific IgM from deer mice (Peromyscus maniculatus)

2008 ◽  
Vol 151 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Mariana G. Bego ◽  
Darcy Bawiec ◽  
Deepa Dandge ◽  
Benjamin Martino ◽  
Denise Dearing ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mice ◽  
Sin Nombre Virus

Relationship of Ecological Variables to sin Nombre Virus Antibody Seroprevalence in Populations of Deer Mice

2000 ◽  
Vol 81 (3) ◽  
pp. 676-682 ◽  
Author(s):  
J. R. Biggs ◽  
K. D. Bennett ◽  
M. A. Mullen ◽  
T. K. Haarmann ◽  
M. Salisbury ◽  
...  
Keyword(s):  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Antibody ◽  
Ecological Variables ◽  
Relationship Of

Sin Nombre Virus Shedding Patterns in Naturally Infected Deer Mice (Peromyscus maniculatus) in Relation to Duration of Infection

2008 ◽  
Vol 8 (1) ◽  
pp. 97-100 ◽  
Author(s):  
David Safronetz ◽  
Michael A. Drebot ◽  
Harvey Artsob ◽  
Tyler Cote ◽  
Kai Makowski ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Shedding ◽  
Duration Of Infection

scholarly journals Phylogeography of the deer mouse (Peromyscus maniculatus) provides a predictive framework for research on hantaviruses

2006 ◽  
Vol 87 (7) ◽  
pp. 1997-2003 ◽  
Author(s):  
Jerry W. Dragoo ◽  
J. Alden Lackey ◽  
Kathryn E. Moore ◽  
Enrique P. Lessa ◽  
Joseph A. Cook ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Peromyscus Maniculatus ◽  
Deer Mouse ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Rodent Host ◽  
Bayesian Analyses ◽  
Future Studies ◽  
Geographical Regions ◽  
Virus Strains

Phylogeographical partitioning of Sin Nombre and Monongahela viruses (hantaviruses) may reflect that of their primary rodent host, the deer mouse (Peromyscus maniculatus). Lack of a comprehensive assessment of phylogeographical variation of the host has precluded the possibility of predicting spatial limits of existing strains of these viruses or geographical regions where novel viral strains might emerge. The complete cytochrome b gene was sequenced for 206 deer mice collected from sites throughout North America to provide a foundation for future studies of spatial structure and evolution of this ubiquitous host. Bayesian analyses of these sequences partitioned deer mice into six largely allopatric lineages, some of which may represent unrecognized species. The geographical distributions of these lineages were probably shaped by Quaternary climatic events. Populations of mice were apparently restricted to refugia during glacial advances, where they experienced genetic divergence. Expansion of these populations, following climatic amelioration, brought genetically distinctive forms into contact. Occurrence of parallel changes in virus strains can now be explored in appropriate regions. In New Mexico, for example, near the location where Sin Nombre virus was first discovered, there are three genetically distinctive lineages of deer mice whose geographical ranges need to be delineated precisely. The phylogeography of P. maniculatus provides a framework for interpreting geographical variability, not only in hosts, but also in associated viral variants and disease transmission, and an opportunity to predict the potential geographical distribution of newly emerging viral strains.

Genetic Relatedness of Deer Mice (Peromyscus maniculatus) Infected with Sin Nombre Virus

2004 ◽  
Vol 4 (2) ◽  
pp. 149-157 ◽  
Author(s):  
J. Jeffrey Root ◽  
William C. Black ◽  
Charles H. Calisher ◽  
Kenneth R. Wilson ◽  
Barry J. Beaty
Keyword(s):  
Peromyscus Maniculatus ◽  
Genetic Relatedness ◽  
Deer Mice ◽  
Sin Nombre Virus

Sin Nombre virus prevalence from 2014–2017 in wild deer mice, Peromyscus maniculatus , on five of the California Channel Islands

2021 ◽  
Author(s):  
John L. Orrock ◽  
Brian M. Connolly ◽  
Peter W. Guiden ◽  
Jennifer L. Chandler ◽  
Gebbiena M. Bron ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Channel Islands ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Prevalence ◽  
California Channel Islands ◽  
Wild Deer
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