Predictive impact of metastatic lymph node burden on distant metastasis across papillary thyroid cancer variants

Thyroid ◽  
2021 ◽  
Author(s):  
Allen S. Ho ◽  
Michael Luu ◽  
Iram Shafqat ◽  
Jon Mallen-St. Clair ◽  
Michelle M Chen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Distant Metastasis ◽  
Metastatic Lymph Node ◽  
Papillary Thyroid ◽  
Metastatic Lymph

scholarly journals MON-447 Schwannoma Masquerading as Metastatic Papillary Thyroid Carcinoma in a Cervical Lymph Node

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Stephanie Kim ◽  
Ruth Goldstein ◽  
Lisa Liu ◽  
Quan-Yang Duh ◽  
Chienying Liu
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Jugular Vein ◽  
Metastatic Lymph Node ◽  
Papillary Thyroid ◽  
Neck Ultrasound ◽  
Nerve Sheath ◽  
Metastatic Lymph ◽  
History Of

Abstract Background: Schwannomas originate from peripheral nerve sheath Schwann cells and develop in various locations, commonly seen in the head and neck in up to 45% of cases. On ultrasound, they appear hypoechoic, lack a hilum, and can resemble a metastatic lymph node in patients with thyroid cancer. We describe a case of a schwannoma masquerading as metastatic papillary thyroid carcinoma. Clinical Case: A 59-year-old woman presented to our clinic with a history of Graves’ disease and papillary thyroid cancer (PTC) for which she underwent surgery over fifteen years ago at an outside institution. Pathology revealed two microfoci of PTC (0.5 and 0.4 cm) and 0 of 3 positive lymph nodes, with no other concerning features. She underwent radioactive iodine therapy (RAI) with 100 mCi postoperatively. There was no evidence of metastasis on her post-treatment scan. She had surveillance including neck ultrasounds with no evidence of recurrence. Five years later, neck ultrasound revealed a 5 mm nodule in the right neck posterior to the jugular vein. This nodule remained stable a year later and was not mentioned on subsequent ultrasounds. Two years ago upon presentation to our institution, she was found to have a suspicious hypoechoic solid mass on neck ultrasound. It was located in the lateral neck deep to the internal jugular vein and immediately adjacent and lateral to the common carotid and measured 8 x 7 x 7 mm enlarging to 13 x 9 x 10 mm in the next year. On one of the ultrasounds, the mass was noted to be inseparable from the surrounding nerve fibers and the possibility of nerve sheath tumor was suggested although a metastatic lymph node could not be excluded. This nodule enlarged to 13 x 9 x 10 mm in the next year. Due to the location, biopsy was deemed difficult and she underwent surgical resection of the mass. Intraoperatively, the lesion was noted to be very firm and intimately involved with the vagus nerve, which had to be sacrificed as it could not be dissected off. Pathology revealed a schwannoma, which was confirmed by immunohistochemical staining. Conclusion: This case highlights the importance of recognizing subtle but important ultrasonographic features of a schwannoma in the neck as it can resemble a metastatic lymph node, especially in a patient with history of thyroid cancer. Clinicians should consider this in the differential diagnosis when there are appropriate imaging findings that may be consistent with a schwannoma, including homogeneous hypoechogeneity and nerve continuity.

TSHR rs2288496 associated with thyroid hormone and predict the occurrence of lymph node metastasis of papillary thyroid cancer

2019 ◽  
Vol 26 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Xuan Su ◽  
Li-Wen Lin ◽  
Jie-Ling Weng ◽  
Shu-Wei Chen ◽  
Xin-Hua Yang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Thyroid Hormone ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Node Metastasis

scholarly journals Fibronectin 1 promotes migration and invasion of papillary thyroid cancer and predicts papillary thyroid cancer lymph node metastasis [Corrigendum]

2017 ◽  
Vol Volume 10 ◽  
pp. 2737-2738
Author(s):  
Shujun Xia ◽  
Chuandong Wang ◽  
Emily Louise Postma ◽  
Yanhua Yang ◽  
Xiaofeng Ni ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Node Metastasis

Accuracy of the Lymph Node Yield in Surgery for Papillary Thyroid Cancer in Children

2021 ◽  
Author(s):  
Ava Yap ◽  
Amy Shui ◽  
Jessica Gosnell ◽  
Chiung-Yu Huang ◽  
Julie Ann Sosa ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Lymph Node Yield ◽  
Cancer In Children ◽  
Node Yield
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