scholarly journals Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study

Thyroid ◽  
2020 ◽  
Author(s):  
Aleksander Kuś ◽  
Eirini Marouli ◽  
Fabiola Del Greco M. ◽  
Layal Chaker ◽  
Tomasz Bednarczuk ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Thyroid Function ◽  
Serum Cholesterol ◽  
Mendelian Randomization ◽  
Diabetes Risk ◽  
Normal Range ◽  
Cholesterol Levels

scholarly journals Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease

2020 ◽  
Vol 29 (19) ◽  
pp. 3327-3337
Author(s):  
Christopher S Thom ◽  
Zhuoran Ding ◽  
Michael G Levin ◽  
Scott M Damrauer ◽  
Kyung Min Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Mendelian Randomization ◽  
Smoking Behavior ◽  
Diabetes Risk ◽  
Genetic Determinants ◽  
Increased Risk ◽  
Artery Disease ◽  
Cad Risk

Abstract Clinical observations have linked tobacco smoking with increased type 2 diabetes risk. Mendelian randomization analysis has recently suggested smoking may be a causal risk factor for type 2 diabetes. However, this association could be mediated by additional risk factors correlated with smoking behavior, which have not been investigated. We hypothesized that body mass index (BMI) could help to explain the association between smoking and diabetes risk. First, we confirmed that genetic determinants of smoking initiation increased risk for type 2 diabetes (OR 1.21, 95% CI: 1.15–1.27, P = 1 × 10−12) and coronary artery disease (CAD; OR 1.21, 95% CI: 1.16–1.26, P = 2 × 10−20). Additionally, 2-fold increased smoking risk was positively associated with increased BMI (~0.8 kg/m2, 95% CI: 0.54–0.98 kg/m2, P = 1.8 × 10−11). Multivariable Mendelian randomization analyses showed that BMI accounted for nearly all the risk smoking exerted on type 2 diabetes (OR 1.06, 95% CI: 1.01–1.11, P = 0.03). In contrast, the independent effect of smoking on increased CAD risk persisted (OR 1.12, 95% CI: 1.08–1.17, P = 3 × 10−8). Causal mediation analyses agreed with these estimates. Furthermore, analysis using individual-level data from the Million Veteran Program independently replicated the association of smoking behavior with CAD (OR 1.24, 95% CI: 1.12–1.37, P = 2 × 10−5), but not type 2 diabetes (OR 0.98, 95% CI: 0.89–1.08, P = 0.69), after controlling for BMI. Our findings support a model whereby genetic determinants of smoking increase type 2 diabetes risk indirectly through their relationship with obesity. Smokers should be advised to stop smoking to limit type 2 diabetes and CAD risk. Therapeutic efforts should consider pathophysiology relating smoking and obesity.

Gallstone Disease and Type 2 Diabetes Risk: A Mendelian Randomization Study

Hepatology ◽  
2019 ◽  
Vol 70 (2) ◽  
pp. 610-620 ◽  
Author(s):  
Fei Wang ◽  
Jing Wang ◽  
Yaru Li ◽  
Jing Yuan ◽  
Ping Yao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mendelian Randomization ◽  
Gallstone Disease ◽  
Diabetes Risk

scholarly journals Association of Serum Cholesterol Levels With Peripheral Nerve Damage in Patients With Type 2 Diabetes

2019 ◽  
Vol 2 (5) ◽  
pp. e194798 ◽  
Author(s):  
Johann M. E. Jende ◽  
Jan B. Groener ◽  
Christian Rother ◽  
Zoltan Kender ◽  
Artur Hahn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Serum Cholesterol ◽  
Nerve Damage ◽  
Peripheral Nerve Damage ◽  
Cholesterol Levels

scholarly journals Roles of Cardiometabolic Factors in Mediating the Causal Effect of Type 2 Diabetes on Cardiovascular Diseases: A Two-Step, Two-Sample Multivariable Mendelian Randomization Study

2021 ◽  
Author(s):  
Ken Chen ◽  
Zhenhuang Zhuang ◽  
Chunli Shao ◽  
Jilin Zheng ◽  
Qing Zhou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Lipids ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
Density Lipoprotein ◽  
Mediation Effect ◽  
Mediation Effects ◽  
Cardiometabolic Factors

Abstract ObjectivesTo investigate the roles of cardiometabolic factors (including blood pressure, blood lipids, thyroid function, body mass, and insulin sensitivity) in mediating the causal effect of type 2 diabetes (T2DM) on cardiovascular disease (CVD) outcomes. DesignTwo-step, two-sample multivariable Mendelian randomization (MVMR) study.SettingInternational genome-wide association study (GWAS) consortia data.ExposureT2DM, blood pressure: systolic blood pressure (SBP), diastolic blood pressure (DBP); blood lipids: low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG); thyroid function: hyperthyroidism, hypothyroidism; body mass index (BMI), waist-hip-ratio (WHR), and insulin sensitivity. Main outcomesCVD including coronary heart disease (CHD), myocardial infarction (MI) and stroke.MethodsSummary-level data for exposures and main outcomes were extracted from GWAS consortia. We used two-sample MR to illustrate the causal effect of T2DM on CVD subtypes and regression-based MVMR to quantify the possible mediation effects of cardiometabolic factors on CVD.ResultsEach additional unit of log odds of T2DM increased 16% risk of CHD [OR: 1.16, 95% confidence interval (CI): 1.12-1.21], 15% risk of MI (OR: 1.15, 95%CI: 1.10-1.20), and 10% risk of stroke (OR: 1.10, 95%CI: 1.06-1.13). In mediation analysis, SBP, DBP and TG were found as main mediators, while the mediation effects of other cardiometabolic factors were not significant. The proportion of total effect of T2DM on CHD mediated by SBP, DBP and TG was 16% (95%CI: 8%-24%), 7% (95%CI: 1%-13%) and 10% (95%CI: 2%-18%), respectively. Mediation effect of SBP and DBP on MI and stroke, TG on MI was also prominent, while mediation effect of TG on stroke was not significant. Combined mediation effect of all three mediators accounted for 29%, 26% and 13% of total effect of T2DM on CHD, MI and stroke, respectively.ConclusionSBP, DBP and TG mediate a substantial proportion of the causal effect of T2DM on CVD and thus interventions on these factors might reduce considerable excess risk of CVD among T2DM patients.

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Hdl Kolesterol Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Arafah Lampung Tengah

2021 ◽  
Vol 1 (4) ◽  
pp. 307-314
Author(s):  
Toni Prasetia ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Ikbal Zaenur Ridwan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE AND HDL CHOLESTEROL LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG Background: Hypertension is a major risk factor for type 2 Diabetes Mellitus, hypertension can make cells insensitive to insulin, so blood sugar levels can also be disrupted. Dyslipidemia causes constriction in blood vessels or atherosclerosis which can aggravate hypertension or diabetes mellitus. Meanwhile, the function of HDL in transporting bad cholesterol also causes blood vessels to dilate due to increased NO production. Objective: To find out the relationship between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung, 2020. Method: This type of research used in this research is descriptive-analytic with cross-sectional design. The sampling technique was total sampling. Respondents in this study were patients with Type 2 Diabetes Mellitus at the Arafah Clinic in Central Lampung in 2020 Results: Based on the results of the chi-square statistical test, it was found that there was no relationship with the results of p = 0.898 (p> 0.05). Conclusion: There is no correlation between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung in 2020. Keywords: Diabetes Mellitus type 2, Systolic Blood Pressure, HDL   INTISARI: HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN KADAR KOLESTEROL HDL PADA PASIEN DIABETES MELLITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAH Latar Belakang: Hipertensi merupakan faktor risiko utama untuk terjadinya Diabetes Melitus tipe 2, hipertensi dapat membuat sel tidak sensitif terhadap insulin, maka kadar gula di dalam darah juga dapat mengalami gangguan. Dislipidimia menyebabkan terjadinya penyempitan dalam pembuluh darah atau aterosklerosis yang dapat memperberat kondisi hipertensi ataupun diabetes mellitus. Sedangkan fungsi HDL mengangkut kolesterol jahat juga menyebabkan pembuluh darah bisa berdilatasi karena produksi NO yang meningkat.Tujuan: Untuk mengetahui Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah Tahun 2020.Metode: Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif analitik dengan desain cross sectional. Teknik pengambilan sampel berupa total sampling. Responden dalam penelitian ini adalah pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah.Hasil: Berdasarkan hasil uji statistic chi-square didapatkan tidak terdapat hubungan dengan hasil p=0,898 (p>0,05).Kesimpulan: Tidak terdapat Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020. Kata Kunci     : Diabetes Melitus tipe 2, Tekanan Darah Sistolik, HDL

scholarly journals Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study

Diabetes ◽  
2016 ◽  
Vol 66 (2) ◽  
pp. 543-550 ◽  
Author(s):  
Rachael C. Aikens ◽  
Wei Zhao ◽  
Danish Saleheen ◽  
Muredach P. Reilly ◽  
Stephen E. Epstein ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Systolic Blood Pressure ◽  
Mendelian Randomization

scholarly journals Bilirubin as a Potential Causal Factor in Type 2 Diabetes Risk: A Mendelian Randomization Study

Diabetes ◽  
2014 ◽  
Vol 64 (4) ◽  
pp. 1459-1469 ◽  
Author(s):  
Ali Abbasi ◽  
Petronella E. Deetman ◽  
Eva Corpeleijn ◽  
Ron T. Gansevoort ◽  
Rijk O.B. Gans ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mendelian Randomization ◽  
Diabetes Risk ◽  
Causal Factor
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