scholarly journals A Positive Feedback Loop Between DICER1 and Differentiation Transcription Factors Is Important for Thyroid Tumorigenesis

Thyroid ◽  
2020 ◽  
Author(s):  
Julia Ramírez-Moya ◽  
Pilar Santisteban
Keyword(s):  
Transcription Factors ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop

scholarly journals Transcription Factors ER71/ETV2 and SOX9 Participate in a Positive Feedback Loop in Fetal and Adult Mouse Testis

2012 ◽  
Vol 287 (28) ◽  
pp. 23657-23666 ◽  
Author(s):  
Luciano DiTacchio ◽  
Josephine Bowles ◽  
Sook Shin ◽  
Dae-Sik Lim ◽  
Peter Koopman ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Adult Mouse ◽  
Mouse Testis ◽  
Positive Feedback Loop

scholarly journals MEF2C is a new regulator of the human articular chondrocyte phenotype

2018 ◽  
Author(s):  
S. Lazzarano ◽  
C.L. Murphy
Keyword(s):  
Transcription Factors ◽  
Articular Cartilage ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Regulator Gene ◽  
Articular Chondrocyte ◽  
Positive Feedback Loop ◽  
Chondrocyte Phenotype ◽  
Cooperative Activity ◽  
First Time

MEF2C plays a role in diverse tissues, most notably heart, brain, eyes and developing bones. Here we report for the first time that MEF2C is present and active in the permanent articular cartilage in humans which lines and protects our joints throughout life. We show that MEF2C directly targets cartilage master regulator gene SOX9, and SOX9, in turn, regulates MEF2C in a novel positive feedback loop maintaining high expression levels of both transcription factors, and consequently stabilising the articular chondrocyte phenotype and helping prevent hypertrophy and subsequent calcification and vascularisation. We propose that MEF2C and SOX9 may show similar cooperative activity in other tissues, and across a range of adult murine tissues we found co-expression of both transcription factors in cartilage, trachea, brain, eyes and heart. Strikingly, all of these tissues are prone to calcification and further study of MEF2C/SOX9 cooperativity in these organs will be revealing.

scholarly journals ROS amplification drives mouse spermatogonial stem cell self-renewal

2019 ◽  
Vol 2 (2) ◽  
pp. e201900374 ◽  
Author(s):  
Hiroko Morimoto ◽  
Mito Kanastu-Shinohara ◽  
Narumi Ogonuki ◽  
Satoshi Kamimura ◽  
Atsuo Ogura ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Nuclear Translocation ◽  
Cell Types ◽  
Spermatogonial Stem Cell ◽  
Self Renewal ◽  
Positive Feedback Loop ◽  
Chemical Screening

Reactive oxygen species (ROS) play critical roles in self-renewal division for various stem cell types. However, it remains unclear how ROS signals are integrated with self-renewal machinery. Here, we report that the MAPK14/MAPK7/BCL6B pathway creates a positive feedback loop to drive spermatogonial stem cell (SSC) self-renewal via ROS amplification. The activation of MAPK14 induced MAPK7 phosphorylation in cultured SSCs, and targeted deletion of Mapk14 or Mapk7 resulted in significant SSC deficiency after spermatogonial transplantation. The activation of this signaling pathway not only induced Nox1 but also increased ROS levels. Chemical screening of MAPK7 targets revealed many ROS-dependent spermatogonial transcription factors, of which BCL6B was found to initiate ROS production by increasing Nox1 expression via ETV5-induced nuclear translocation. Because hydrogen peroxide or Nox1 transfection also induced BCL6B nuclear translocation, our results suggest that BCL6B initiates and amplifies ROS signals to activate ROS-dependent spermatogonial transcription factors by forming a positive feedback loop.

scholarly journals AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons

2016 ◽  
Vol 36 (4) ◽  
pp. 1290-1305 ◽  
Author(s):  
J. Tuvikene ◽  
P. Pruunsild ◽  
E. Orav ◽  
E.-E. Esvald ◽  
T. Timmusk
Keyword(s):  
Transcription Factors ◽  
Positive Feedback ◽  
Cortical Neurons ◽  
Feedback Loop ◽  
Positive Feedback Loop
Sign in / Sign up

Export Citation Format

Share Document