scholarly journals Clinical Parameters Are More Likely to Be Associated with Thyroid Hormone Levels than with Thyrotropin Levels: A Systematic Review and Meta-Analysis

Thyroid ◽  
2020 ◽  
Vol 30 (12) ◽  
pp. 1695-1709 ◽  
Author(s):  
Stephen P. Fitzgerald ◽  
Nigel G. Bean ◽  
Henrik Falhammar ◽  
Jono Tuke
Keyword(s):  
Systematic Review ◽  
Thyroid Hormone ◽  
Meta Analysis ◽  
Clinical Parameters ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review

2020 ◽  
Vol 33 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Mahshid Gheidarloo ◽  
Roya Kelishadi ◽  
Silva Hovsepian ◽  
Mojtaba Keikha ◽  
Mahin Hashemipour
Keyword(s):  
Systematic Review ◽  
Thyroid Hormone ◽  
Organochlorine Pesticides ◽  
Thyroid Function ◽  
Prenatal Exposure ◽  
Thyroid Function Tests ◽  
Hormone Levels ◽  
Fetal Thyroid ◽  
Thyroid Hormone Levels ◽  
Organochlorine Pollutant

AbstractIn this systematic review, the association between prenatal exposure to organochlorine pesticides (OCPs) and neonatal thyroid hormone levels was studied. A systematic search of scientific literature was performed from the PubMed, SCOPUS and ISI web of science electronic bibliographic databases. The search strategy for the review was [(organochlorine OR “organochlorine pesticides” OR “organochlorine pollutants” OR “organochlorine pollutant”) AND (“thyroid hormone” OR triiodothyronine OR Thyroxine OR “fetal thyroid function” OR “thyroid function” OR “Thyroid Stimulating Hormone” AND “prenatal” AND “maternal exposure”)] in English sources. In this review, 305 papers (PubMed: 30; Scopus: 29; ISI: 246) were identified through an electronic database search. Twenty-seven articles were assessed for eligibility, from which 16 qualified articles were selected for the final evaluation. The most common OCP metabolites which were evaluated in order were hexachlorobenzene (HCB) (13 studies), pp-dichlorodiphenyldichloroethylene (pp-DDE) (13 studies), hexachlorocyclohexane (HCH) (10 studies) and dichlorodiphenyltrichlorethane (DDT) (eight studies). A review of the documents related to the association of prenatal exposure of OCPs with fetal or neonatal thyroid function tests provides us with heterogeneous data in this field. Factors such as differences in the studied populations and their area, ethnic and genetic background, time and rate of exposure, possible interaction of other thyroid-disrupting environmental factors and dietary intake of micronutrients such as iodine and/or selenium are considered the main limitations for making an accurate conclusion. For some OCPs including DDT, DDE, HCH and HCB, there are supporting evidences, and it is suggested that their exposure could potentially alter the fetal thyroid function and consequently impair the neurodevelopment process of the infants.

scholarly journals Genome-wide association meta-analysis for total thyroid hormone levels in Croatian population

2019 ◽  
Vol 64 (5) ◽  
pp. 473-480
Author(s):  
Ivana Gunjača ◽  
Antonela Matana ◽  
Thibaud Boutin ◽  
Vesela Torlak ◽  
Ante Punda ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Hormone Levels ◽  
Genome Wide ◽  
Thyroid Hormone Levels

scholarly journals Associations of Prenatal Exposure to Triclosan and Maternal Thyroid Hormone Levels: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Danrong Chen ◽  
Jiani Liu ◽  
Wu Yan ◽  
Kacey Fang ◽  
Yankai Xia ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Prenatal Exposure ◽  
Meta Analysis ◽  
Descriptive Analysis ◽  
Cochrane Library ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Maternal Thyroid ◽  
The Relationship ◽  
Tsh Levels

ObjectiveTo quantitatively evaluate associations between exposure to triclosan during pregnancy and maternal thyroid hormone levels.MethodThe databases of PubMed, Embase, Web of Science and Cochrane Library were systematically searched to identify relevant studies on the relationship between prenatal exposure to triclosan and maternal levels of serum thyroid hormone published before October 22, 2019. Stata 12.0 was used to examine the heterogeneity among the eligible studies.ResultsSeven studies involving a total of 4,136 participants were included. Overall, descriptive analysis provided no indication that exposure to TCS during pregnancy was related to either maternal FT4 levels (ES = 0.01, 95% CI: −0.03 to 0.05, P = 0.00) or TSH levels (ES = −0.03, 95% CI: −0.13 to 0.07, P = 0.412). Although the results were statistically insignificant, with the increase of urine TCS concentration, maternal FT4 levels exhibited a tendency to increase while TSH levels had a tendency to decrease during pregnancy.ConclusionThe results indicated that exposure to triclosan during pregnancy has no significant influence on maternal levels of thyroid hormone. On account of the inconsistency of existing research designs and study locations, further studies and replication are necessary to confirm these findings.

scholarly journals GENETICS IN ENDOCRINOLOGY: Genetic variation in deiodinases: a systematic review of potential clinical effects in humans

2014 ◽  
Vol 171 (3) ◽  
pp. R123-R135 ◽  
Author(s):  
Herman Verloop ◽  
Olaf M Dekkers ◽  
Robin P Peeters ◽  
Jan W Schoones ◽  
Johannes W A Smit
Keyword(s):  
Systematic Review ◽  
Genetic Variation ◽  
Thyroid Hormone ◽  
Cochrane Library ◽  
Publication Date ◽  
Clinical Effects ◽  
Hormone Levels ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels

Iodothyronine deiodinases represent a family of selenoproteins involved in peripheral and local homeostasis of thyroid hormone action. Deiodinases are expressed in multiple organs and thyroid hormone affects numerous biological systems, thus genetic variation in deiodinases may affect multiple clinical endpoints. Interest in clinical effects of genetic variation in deiodinases has clearly increased. We aimed to provide an overview for the role of deiodinase polymorphisms in human physiology and morbidity. In this systematic review, studies evaluating the relationship between deiodinase polymorphisms and clinical parameters in humans were eligible. No restrictions on publication date were imposed. The following databases were searched up to August 2013: Pubmed, EMBASE (OVID-version), Web of Science, COCHRANE Library, CINAHL (EbscoHOST-version), Academic Search Premier (EbscoHOST-version), and ScienceDirect. Deiodinase physiology at molecular and tissue level is described, and finally the role of these polymorphisms in pathophysiological conditions is reviewed. Deiodinase type 1 (D1) polymorphisms particularly show moderate-to-strong relationships with thyroid hormone parameters, IGF1 production, and risk for depression. D2 variants correlate with thyroid hormone levels, insulin resistance, bipolar mood disorder, psychological well-being, mental retardation, hypertension, and risk for osteoarthritis. D3 polymorphisms showed no relationship with inter-individual variation in serum thyroid hormone parameters. One D3 polymorphism was associated with risk for osteoarthritis. Genetic deiodinase profiles only explain a small proportion of inter-individual variations in serum thyroid hormone levels. Evidence suggests a role of genetic deiodinase variants in certain pathophysiological conditions. The value for determination of deiodinase polymorphism in clinical practice needs further investigation.

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