Diagnosing Thyrotropin-Secreting Pituitary Adenomas by Short-Term Somatostatin Analogue Test

Thyroid ◽  
2020 ◽  
Vol 30 (9) ◽  
pp. 1236-1244
Author(s):  
Rulai Han ◽  
Liyun Shen ◽  
Jie Zhang ◽  
Jing Xie ◽  
Wenqiang Fang ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Somatostatin Analogue ◽  
Short Term

scholarly journals Germline mutations of AIP gene in somatotropinomas resistant to somatostatin analogues

2013 ◽  
Vol 168 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Josep Oriola ◽  
Tomás Lucas ◽  
Irene Halperin ◽  
Mireia Mora ◽  
Ma José Perales ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Conventional Treatment ◽  
Poor Response ◽  
Germline Mutations ◽  
Somatostatin Analogues ◽  
Age At Diagnosis ◽  
Somatostatin Analogue ◽  
Endocrine Tumors ◽  
Peg Treatment ◽  
Aip Gene

ObjectiveMost cases of familial isolated pituitary adenomas with mutated aryl hydrocarbon receptor-interacting protein (AIP:HGNC:358) gene develop somatotropinomas. They are characterised by an aggressive clinical phenotype including early age at diagnosis, large tumours and frequent invasiveness. There is little information on AIP gene mutations' prevalence in isolated somatotropinomas characterised by poor response to somatostatin analogue treatment. The aim of this study was to investigate the prevalence of AIP mutations in non-familial cases of somatotropinomas with poor response to conventional treatment.Design and methodsFifty patients with acromegaly (22 males/28 females, age 51±18 years) and 60 controls were included in this study performed at eight University Hospitals in Spain. None had family history of pituitary adenomas or other endocrine tumors. All patients failed to respond to conventional treatment including surgery and somatostatin analogues. Some patients received adjuvant radiotherapy and most cases required pegvisomant (PEG) treatment for normalisation of IGF1. AIP analysis was performed in DNA extracted from peripheral leucocytes, using standardised PCR protocol in which the coding regions of exons 1, 2, 3, 4, 5 and 6 were amplified. Possible deletions/duplications were studied using multiplex ligation-dependent probe amplification.ResultsSequence changes of potential different significance that could be considered as mutations or variations of unknown significance (VUS) of the AIP gene were found in four patients (8%). In two cases, two different mutations previously described were found: p.Arg9Gln and p.Phe269Phe. Two other VUS were also found: c.787+24C>T in intron 5 and c.100-18C>T in intron 1. Age at diagnosis ranged from 21 to 50 years old, and in all patients, the tumor was a macroadenoma depicting IGF1 normalisation under PEG treatment.ConclusionsAIP germline mutations show a low, but non-negligible, prevalence in non-familial acromegaly patients with tumors resistant to treatment with somatostatin analogues.

Response of Thyrotropin-Secreting Pituitary Adenomas to a Long-Acting Somatostatin Analogue

1987 ◽  
Vol 317 (1) ◽  
pp. 12-17 ◽  
Author(s):  
R.J. Comi ◽  
N. Gesundheit ◽  
L. Murray ◽  
P. Gorden ◽  
B.D. Weintraub
Keyword(s):  
Pituitary Adenomas ◽  
Somatostatin Analogue ◽  
Long Acting

Predicting short-term recurrence in pituitary adenomas: Phosphohistone-H3 (Ser 10) proves an effective biomarker

2020 ◽  
Vol 39 (03) ◽  
pp. 70-79
Author(s):  
Chao Li ◽  
Liudong Wei ◽  
Lianwang Li ◽  
Junmei Wang ◽  
Runting Li ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Short Term ◽  
Phosphohistone H3

Short-Term Endocrinological Results after Gamma Knife Surgery of Pituitary Adenomas

1998 ◽  
Vol 70 (1) ◽  
pp. 127-138 ◽  
Author(s):  
I. Morange-Ramos ◽  
J. Régis ◽  
H. Dufour ◽  
J.M. Andrieu ◽  
F. Grisoli ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Pituitary Adenomas ◽  
Gamma Knife Surgery ◽  
Short Term

Short-term treatment with cabergoline can lead to tumor shrinkage in patients with nonfunctioning pituitary adenomas

Pituitary ◽  
2012 ◽  
Vol 16 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Erica C. Garcia ◽  
Luciana A. Naves ◽  
Arthur O. Silva ◽  
Lucas F. de Castro ◽  
Luiz A. Casulari ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Term Treatment ◽  
Tumor Shrinkage ◽  
Short Term ◽  
Short Term Treatment ◽  
Nonfunctioning Pituitary Adenomas

scholarly journals The short-term treatment of a VIPoma with somatostatin analogue in advance of curative operation.

1988 ◽  
Vol 77 (8) ◽  
pp. 1276-1277
Author(s):  
Mitsuaki YOSHIOKA ◽  
Minoru SAKAZUME ◽  
Mitsutoshi FUKAGAWA ◽  
Tsuyoshi SEKI
Keyword(s):  
Term Treatment ◽  
Somatostatin Analogue ◽  
Short Term ◽  
Short Term Treatment ◽  
Curative Operation

scholarly journals SOM230, A New Somatostatin Analogue, Is Highly Effective in the Therapy of Growth Hormone/Prolactin-Secreting Pituitary Adenomas

2007 ◽  
Vol 13 (9) ◽  
pp. 2738-2744 ◽  
Author(s):  
Monica Fedele ◽  
Ivana De Martino ◽  
Rosario Pivonello ◽  
Andrea Ciarmiello ◽  
M. Laura Del Basso De Caro ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenomas ◽  
Somatostatin Analogue ◽  
Highly Effective
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