Role of18F-Choline Positron Emission Tomography/Computed Tomography to Detect Structural Relapse in High-Risk Differentiated Thyroid Cancer Patients

Thyroid ◽  
2019 ◽  
Vol 29 (4) ◽  
pp. 549-556 ◽  
Author(s):  
Arnoldo Piccardo ◽  
Pierpaolo Trimboli ◽  
Matteo Puntoni ◽  
Luca Foppiani ◽  
Giorgio Treglia ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Thyroid Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Differentiated Thyroid Cancer ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

2013 ◽  
Vol 20 (4) ◽  
pp. R203-R213 ◽  
Author(s):  
Kyoungjune Pak ◽  
Seong-Jang Kim ◽  
In Joo Kim ◽  
Bo Hyun Kim ◽  
Sang Soo Kim ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Thyroid Cancer ◽  
High Risk ◽  
Fdg Pet ◽  
Differentiated Thyroid Cancer ◽  
Preoperative Assessment ◽  
Emission Tomography ◽  
Follicular Neoplasm ◽  
Positron Emission ◽  
Fdg Avidity

The incidence of thyroid cancer in both men and women is increasing faster than that of any other cancer. Although positron emission tomography (PET) using18F-fluorodeoxyglucose (FDG) has received much attention, the use of FDG PET for the management of thyroid cancer is limited primarily to postoperative follow-up. However, it might have a role in selected, more aggressive pathologies, and so patients at a high risk of distant metastasis may benefit from PET before surgery. As less FDG-avid thyroid cancers may lower the diagnostic accuracy of PET in preoperative assessment, an understanding of FDG avidity is important for the evaluation of thyroid cancer. FDG avidity has been shown to be associated with tumor size, lymph node metastasis, and glucose transporter expression and differentiation. As PET is commonly used in clinical practice, the detection of incidentalomas by PET is increasing. However, incidentalomas detected by PET have a high risk of malignancy. Clinicians handling cytologically indeterminate nodules face a dilemma regarding a procedure for a definitive diagnosis, usually lobectomy. With ‘nondiagnostic (ND)’ fine-needle biopsy (FNA), PET has shown a negative predictive value (NPV) of 100%, which indicates that negative uptake in a ND FNA procedure accurately excludes malignancy. With ‘atypia of undetermined significance’ or ‘follicular neoplasm’, the sensitivity and NPV of PET are 84 and 88%. PET does not provide additional information for the preoperative assessment of thyroid cancer. However, factors associated with FDG positivity are related to a poor prognosis; therefore, FDG PET scans before surgery may facilitate the prediction of the prognosis of differentiated thyroid cancer.

124I Positron Emission Tomography/Computed Tomography Versus Conventional Radioiodine Imaging in Differentiated Thyroid Cancer: A Review

Thyroid ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1523-1535 ◽  
Author(s):  
Di Wu ◽  
Dorina Ylli ◽  
S. Layla Heimlich ◽  
Kenneth D. Burman ◽  
Leonard Wartofsky ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Emission Tomography ◽  
Positron Emission ◽  
Radioiodine Imaging
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