scholarly journals Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis

Thyroid ◽  
2019 ◽  
Vol 29 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Massimo Bongiovanni ◽  
Luca Giovanella ◽  
Francesco Romanelli ◽  
Pierpaolo Trimboli
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Thyroid Neoplasms ◽  
Bethesda System ◽  
Thyroid Cytopathology ◽  
The Bethesda System ◽  
Nuclear Features

scholarly journals The Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis

2012 ◽  
Vol 56 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Massimo Bongiovanni ◽  
Alessandra Spitale ◽  
William C. Faquin ◽  
Luca Mazzucchelli ◽  
Zubair W. Baloch
Keyword(s):  
Meta Analysis ◽  
Bethesda System ◽  
Thyroid Cytopathology ◽  
The Bethesda System

The Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis

2017 ◽  
Vol 61 (2) ◽  
pp. 172-172 ◽  
Author(s):  
Maher A. Sughayer ◽  
Niveen Abdullah
Keyword(s):  
Meta Analysis ◽  
Bethesda System ◽  
Thyroid Cytopathology ◽  
The Bethesda System

scholarly journals Impact of non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) on risk of malignancy in patients undergoing lobectomy/thyroidectomy for suspected malignancy or malignant fine-needle aspiration cytology findings: a systematic review and meta-analysis

2019 ◽  
Vol 181 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Massimo Bongiovanni ◽  
William C Faquin ◽  
Luca Giovanella ◽  
Cosimo Durante ◽  
Peter Kopp ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Thyroid Neoplasms ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Diagnostic Categories ◽  
Non Invasive ◽  
Risk Of Malignancy ◽  
Needle Aspiration Cytology ◽  
Nuclear Features

Objective The second version of The Bethesda System for Reporting Thyroid Cytopathology endorsed the introduction of non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) as a distinct entity with low malignant potential into clinical practice. Consequently, the risk of malignancy (ROM) of cytological diagnoses has changed, but the magnitude of the change remains uncertain. The present systematic review was undertaken to obtain more robust information about the true impact of NIFTP on the ROM among patients undergoing surgery following a fine-needle aspiration cytology (FNAC) diagnosis of suspicious for malignancy (Bethesda V) or malignant (Bethesda VI). As they are managed surgically, these two diagnostic categories are the primary entities that are clinically impacted by the advent of NIFTP. Design Systematic review and meta-analysis. Methods A comprehensive literature search of online databases was performed in November 2018. The search was conducted looking for data of histologically proven NIFTP with preoperative FNAC. Results One-hundred fifty-seven articles were identified and nine were included in the study. Overall, there were 13,752 thyroidectomies with a cancer prevalence of 45.7%. When NIFTP was considered non-malignant, the pooled risk difference for ROM was 5.5%. Applying meta-analysis, the pooled prevalence of NIFTP among nodules with FNAC of Bethesda V or Bethesda VI was 14 and 3%, respectively. Conclusion This meta-analysis shows that the inclusion of NIFTP leads to a reduction in the ROM for the Bethesda V and Bethesda VI FNAC diagnostic categories by 14 and 3%, respectively. Clinicians should be aware of these data to avoid overtreatment.

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