scholarly journals Response to Cuttler et al. re: “Low-Dose Childhood Radiation Effects to the Thyroid Follow a Linear Dose–Response Trend and Persist Even 45+ Years After Exposure”

Thyroid ◽  
2018 ◽  
Vol 28 (5) ◽  
pp. 680-681
Author(s):  
Angela M. Leung ◽  
Jay H. Lubin ◽  
Arthur B. Schneider
Keyword(s):  
Dose Response ◽  
Radiation Effects ◽  
Low Dose ◽  
Linear Dose

The Thermoluminescence Performance of Ge- Doped Optical Fibres To 6 Mv Photon Irradiations

2014 ◽  
Vol 71 (5) ◽  
Author(s):  
E.I.M.K. Ariffin ◽  
F. Sallih ◽  
S. Hashim ◽  
S. Zakariah ◽  
M.I.C Pi
Keyword(s):  
Optical Fibre ◽  
Dose Response ◽  
Linear Accelerator ◽  
Radiation Dosimetry ◽  
Low Dose ◽  
Optical Fibres ◽  
Photon Irradiation ◽  
Linear Dose ◽  
Different Diameters

The study focus on thermoluminescence (TL) response of five different diameters ~120, 241, 362, 483 and 604 μm of 8 mol% Ge-doped optical fibres. The irradiation was performed using Linear Accelerator (LINAC) Model Primus MLC Siemens provided by the Hospital Sultan Ismail, Johor Bahru at 6 MV photon irradiation with delivered doses ranging from 0.5 – 4.0 Gy. The results show the linear dose response against TL signals up to 4 Gy. The diameter of 483 μm optical fibre shows the highest in TL dose response and sensitivity compared to other fibres. The sensitivity of 483 µm optical fibre are almost 1.6 times  more than 604 µm. The linear dose response at low dose makes this optical fibre suitable to be used in radiation dosimetry application.

scholarly journals The Double Threshold: Consequences for Identifying Low-Dose Radiation Effects

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582094972
Author(s):  
Alan Waltar ◽  
Ludwig Feinendegen
Keyword(s):  
Dose Response ◽  
Radiation Effects ◽  
Low Dose ◽  
Development Program ◽  
Absorbed Dose ◽  
Current Data ◽  
Whole Body ◽  
Radiation Quality ◽  
Adaptive Protection ◽  
New Research

Prior to observing low-dose-induced cell signaling and adaptive protection, radiogenic stochastic effects were assumed to be linearly related to absorbed dose. Now, abundant data prove the occurrence of radiogenic adaptive protection specifically at doses below ∼ 200 mGy (with some data suggesting such protection at a dose even higher than 200 mGy). Moreover, cells do not thrive properly when deprived of radiation below background dose. Two threshold doses need be considered in constructing a valid dose-response relationship. With doses beginning to rise from zero, cells increasingly escape radiation deprivation. The dose at which radiation-deprived cells begin to function homeostatically provides dose Threshold A. With further dose increase, adaptive protection becomes prominent and then largely disappears at acute doses above ∼ 200 mGy. The dose at which damage begins to override protection defines Threshold B. Thresholds A and B should be terms in modeling dose-response functions. Regarding whole-body responses, current data suggest for low-LET acute, non-chronic, irradiation a Threshold B of about 100 mGy prevails, except for leukemia and probably some other malignancies, and for chronic, low dose-rate irradiation where the Threshold B may well reach 1 Gy per year. A new Research and Development Program should determine individual Thresholds A and B for various radiogenic cell responses depending on radiation quality and target.

scholarly journals Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

Toxicology ◽  
2017 ◽  
Vol 375 ◽  
pp. 48-57 ◽  
Author(s):  
Guillemette Crépeaux ◽  
Housam Eidi ◽  
Marie-Odile David ◽  
Yasmine Baba-Amer ◽  
Eleni Tzavara ◽  
...  
Keyword(s):  
Dose Response ◽  
Aluminium Hydroxide ◽  
Low Dose ◽  
Linear Dose ◽  
Non Linear

scholarly journals Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Ning Liu ◽  
Yang Peng ◽  
Xinguang Zhong ◽  
Zheng Ma ◽  
Suiping He ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Dose Response ◽  
Low Dose ◽  
Linear Trend ◽  
Hematological Parameters ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Spline Models ◽  
Cumulative Radiation Dose

Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (Ptrend = 0.258), the non-linear trend tested was statistically significant (Pnon-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.

Using a Temperature-Switching Approach to Evaluate Low-Dose-Rate Ionizing Radiation Effects on SET in Linear Bipolar Circuits

2019 ◽  
Vol 66 (7) ◽  
pp. 1557-1565 ◽  
Author(s):  
Shuai Yao ◽  
Wu Lu ◽  
Xin Yu ◽  
Qi Guo ◽  
Chengfa He ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Radiation Effects ◽  
Low Dose ◽  
Low Dose Rate
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