Reassessment of Differentiated Thyroid Cancer Patients Using the Eighth TNM/AJCC Classification System: A Comparative Study

Thyroid ◽  
2018 ◽  
Vol 28 (2) ◽  
pp. 201-209 ◽  
Author(s):  
Miriam Shteinshnaider ◽  
Limor Muallem Kalmovich ◽  
Shlomit Koren ◽  
Karen Or ◽  
Dror Cantrell ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Comparative Study ◽  
Cancer Patients ◽  
Classification System ◽  
Differentiated Thyroid Cancer ◽  
System A

Impact of age at the diagnosis of radioiodine resistance in differentiated thyroid cancer patients

2019 ◽  
Author(s):  
Clotilde Saie ◽  
Johanna Wassermann ◽  
Elise Mathy ◽  
Sophie Tezenas ◽  
Nathalie Chereau ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Differentiated Thyroid Cancer

scholarly journals Is prophylactic central neck dissection necessary for cN0 differentiated thyroid cancer patients at initial treatment? A meta-analysis of the literature

2017 ◽  
Vol 37 (1) ◽  
pp. 1-8
Author(s):  
J. Liang ◽  
Z. Li ◽  
F. Fang ◽  
T. Yu ◽  
C. Leone
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Differentiated Thyroid Cancer ◽  
Web Of Science ◽  
Meta Analysis ◽  
Central Neck Dissection ◽  
Cochrane Library ◽  
Central Neck ◽  
Sono Stati ◽  
Prophylactic Central Neck Dissection

Le metastasi ai linfonodi del compartimento centrale del collo sono comuni nei pazienti affetti da carcinoma differenziato della tiroide (DTC). La gestione dei pazienti con stadiazione preoperatoria cN0 è ancora dibattuta. L’obiettivo di questo lavoro è stato quello di analizzare le differenze in merito a ricorrenza e complicanze chirurgiche tra tiroidectomia (TT) isolata e TT associata a svuotamento linfonodale profilattico del compartimento centrale del collo (pCND) come trattamenti iniziali di pazienti con DTC cN0, e di valutare l’importanza clinica del pCND per questi pazienti. I database PubMed, Ovid, Cochrane Library e Web of Science sono stati analizzati scrupolosamente, e sono stati identificati ventitré articoli per un totale di 6823 pazienti. La qualità di evidenza è stata valutata tramite lo score di Jadad e tramite la Newcastle-Ottawa Quality assessment scale. I risultati hanno mostrato che i pazienti sottoposti a TT e pCND, se paragonati ai pazienti sottoposti a TT isolata, hanno avuto un tasso significativamente più alto di lesioni transitorie del nervo laringeo inferiore (p = 0,023), di ipocalcemia transitoria (p < 0,01) e di ipocalcemia permanente (p < 0,01). Inoltre è stato rilevato un trend in diminuzione per quel che riguarda il tasso di ricorrenza nei pazienti sottoposti a TT e pCND (p < 0,01). La tiroidectomia totale associata allo svuotamento del compartimento centrale del collo come trattamento iniziale per quei pazienti con cN0 potrebbe ridurre il rischio di ricorrenza di malattia, ma aumenta l’incidenza di alcune complicanze. Si rendono necessari ulteriori studi di maggior qualità metodologica.

Lowest effective 131I activity for thyroid remnant ablation of differentiated thyroid cancer patients

2015 ◽  
Vol 54 (03) ◽  
pp. 137-143 ◽  
Author(s):  
A.-S. Moldovan ◽  
M. Ruhlmann ◽  
R. Görges ◽  
A. Bockisch ◽  
S. Rosenbaum-Krumme ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Differentiated Thyroid Cancer ◽  
Absorbed Dose ◽  
Thyroid Remnant ◽  
Remnant Ablation ◽  
Dose Threshold ◽  
131I Activity ◽  
Pet Ct ◽  
Absorbed Radiation Dose

SummaryAim: A theoretical dosimetry-based model was applied to estimate the lowest effective radioiodine activity for thyroid remnant ablation of low-risk differentiated thyroid cancer patients. Patients, methods: The model is based on the distribution of the absorbed (radiation) dose per administered radioiodine activity and the absorbed dose threshold of 300 Gy for thyroid remnants, the level believed to destroy most thyroid remnants. For this purpose, 124I PET/CT images of 49 thyroid-ectomised patients were retrospectively analysed to measure the distribution of the (average) absorbed doses to thyroid remnant per administered 131I activity. The fraction of thyroid remnants that received at least 300 Gy was determined for standard activities between 0.37 and 5.55 GBq. The lower activity was considered to be equally effective to that obtained with higher activity if the (absolute) fraction difference was below 5%. Results: A total of 62 thyroid remnants were included. The medians and ranges (in parentheses) for the absorbed dose per unit 131I activity were 359 Gy/GBq (34 to 1825 Gy/ GBq). The fractions of thyroid remnants receiving more than 300 Gy at different therapy activities (within parentheses) were 60% (1.11 GBq), 76% (1.85 GBq), 79% (2.22 GBq), and 81–82% for activities between 2.59 and 3.70 GBq. The therapy activity of 1.11 GBq is considerably less effective than that of 1.85 or 2.22 GBq; therapy activities were equally effective in the range between 2.22 to 3.70 GBq. Conclusion: On the basis of the model and the patients' data included, the lowest effective therapy activity appears to be approximately 2.2 GBq to ablate thyroid remnants. The results of this study may help to guide the design of prospective clinical studies.

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