The Concerted Action of Type 2 and Type 3 Deiodinases Regulates the Cell Cycle and Survival of Basal Cell Carcinoma Cells

Thyroid ◽  
2017 ◽  
Vol 27 (4) ◽  
pp. 567-576 ◽  
Author(s):  
Caterina Miro ◽  
Raffaele Ambrosio ◽  
Maria Angela De Stefano ◽  
Daniela Di Girolamo ◽  
Emery Di Cicco ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Carcinoma Cells ◽  
Concerted Action ◽  
Type 3

Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells

2012 ◽  
Vol 258 (2) ◽  
pp. 199-207 ◽  
Author(s):  
Li-Wen Huang ◽  
Bau-Shan Hsieh ◽  
Hsiao-Ling Cheng ◽  
Yu-Chen Hu ◽  
Wen-Tsan Chang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Cycle Arrest ◽  
Basal Cell ◽  
Interleukin 6 ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Human Basal Cell Carcinoma

scholarly journals Role of CRD-BP in the Growth of Human Basal Cell Carcinoma Cells

2014 ◽  
Vol 134 (6) ◽  
pp. 1718-1724 ◽  
Author(s):  
Felicite K. Noubissi ◽  
TaeWon Kim ◽  
Tisha N. Kawahara ◽  
William D. Aughenbaugh ◽  
Eric Berg ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Carcinoma Cells ◽  
Human Basal Cell Carcinoma

scholarly journals DDX5 Silencing Suppresses the Migration of Basal cell Carcinoma Cells by Downregulating JAK2/STAT3 Pathway

2019 ◽  
Vol 18 ◽  
pp. 153303381989225 ◽  
Author(s):  
Zhe Quan ◽  
Bei-bei Zhang ◽  
Fang Yin ◽  
Jiru Du ◽  
Yuan-ting Zhi ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Human Cancer ◽  
Carcinoma Cells ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Migration And Invasion ◽  
Stat3 Pathway

Basal cell carcinoma is driven by the aberrant activation of hedgehog signaling. DEAD (Asp-Glu-Ala-Asp) box protein 5 is frequently overexpressed in human cancer cells and associated with the tumor growth and invasion. The purpose of this study was to investigate the role of DEAD (Asp-Glu-Ala-Asp) box protein 5 in the growth, migration, and invasion of basal cell carcinoma. The role of DEAD (Asp-Glu-Ala-Asp) box protein 5 was detected by quantitative real-time polymerase chain reaction, Western blot, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay in basal cell carcinoma cells. The associations between JAK2/STAT3 pathway and DEAD (Asp-Glu-Ala-Asp) box protein 5 were analyzed in basal cell carcinoma cells. Results showed that DEAD (Asp-Glu-Ala-Asp) box protein 5 is overexpressed in basal cell carcinoma cells. DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown inhibited the migration and invasion of basal cell carcinoma cells. DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown increased the apoptosis of basal cell carcinoma cells induced by tunicamycin. Results found that DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown increased JAK2 and STAT3 expression in basal cell carcinoma cells. JAK2 inhibitor decreased STAT3 expression and abolished the inhibitory effects of DEAD (Asp-Glu-Ala-Asp) box protein 5 silencing on migration and invasion in basal cell carcinoma cells. In conclusion, these results indicate that DEAD (Asp-Glu-Ala-Asp) box protein 5 is a potential target for inhibiting basal cell carcinoma cells growth, migration, and invasion by downregulating JAK2/STAT3 pathway.

scholarly journals Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling

2017 ◽  
Vol 93 (4) ◽  
pp. 999-1007 ◽  
Author(s):  
Arpit Dheeraj ◽  
Cynthia M. Rigby ◽  
Cindy L. O'Bryant ◽  
Chapla Agarwal ◽  
Rana P. Singh ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Carcinoma Cells ◽  
Hedgehog Inhibitor

scholarly journals CD200-expressing human basal cell carcinoma cells initiate tumor growth

2013 ◽  
Vol 110 (4) ◽  
pp. 1434-1439 ◽  
Author(s):  
Chantal S. Colmont ◽  
Antisar BenKetah ◽  
Simon H. Reed ◽  
Nga V. Hawk ◽  
William G. Telford ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Carcinoma Cells ◽  
Human Basal Cell Carcinoma
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