Dynamic Risk Stratification for Predicting Recurrence in Patients with Differentiated Thyroid Cancer Treated Without Radioactive Iodine Remnant Ablation Therapy

Thyroid ◽  
2017 ◽  
Vol 27 (4) ◽  
pp. 524-530 ◽  
Author(s):  
Suyeon Park ◽  
Won Gu Kim ◽  
Eyun Song ◽  
Hye-Seon Oh ◽  
Mijin Kim ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Risk Stratification ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Remnant Ablation ◽  
Ablation Therapy ◽  
Dynamic Risk

scholarly journals Dynamic Risk Stratification in Patients with Differentiated Thyroid Cancer Treated Without Radioactive Iodine

2016 ◽  
Vol 101 (7) ◽  
pp. 2692-2700 ◽  
Author(s):  
Denise P. Momesso ◽  
Fernanda Vaisman ◽  
Samantha P. Yang ◽  
Daniel A. Bulzico ◽  
Rossana Corbo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Risk Stratification ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Response To Therapy ◽  
Therapy Assessment ◽  
Dynamic Risk ◽  
Incomplete Response ◽  
Risk Estimates ◽  
Negative Imaging

Context: Although response to therapy assessment is a validated tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC) treated with total thyroidectomy (TT) and radioactive iodine therapy (RAI), it has not been well studied in patients treated with lobectomy or TT without RAI. Because these responses to therapy definitions are heavily dependent on serum thyroglobulin (Tg) levels, modifications of the original definitions were needed to appropriately classify patients treated without RAI. Objective: This study aimed to validate the response to therapy assessment in patients with DTC treated with lobectomy or TT without RAI. Design and Setting: This was a retrospective study, which took place at a referral center. Patients: A total of 507 adults with DTC were treated with lobectomy (n = 187) or TT (n = 320) without RAI. They had a median age of 43.7 y, 88% were female, 85.4% had low risk, and 14.6% intermediate risk. Main Outcome Measure: Main outcome measured was recurrent/persistent structural evidence of disease (SED) during a median followup period of 100.5 months (24–510). Results: Recurrent/persistent SED was observed in 0% of the patients with excellent response to therapy (nonstimulated Tg for TT < 0.2 ng/mL and for lobectomy < 30 ng/mL, undetectable Tg antibodies [TgAb] and negative imaging; n = 326); 1.3% with indeterminate response (nonstimulated Tg for TT 0.2–5 ng/mL, stable or declining TgAb and/or nonspecific imaging findings; n = 2/152); 31.6% of the patients with biochemical incomplete response (nonstimulated Tg for TT > 5 ng/mL and for lobectomy > 30 ng/mL and/or increasing Tg with similar TSH levels and/or increasing TgAb and negative imaging; n = 6/19) and all (100%) patients with structural incomplete response (n = 10/10) (P < .0001). Initial American Thyroid Association risk estimates were significantly modified based on response to therapy assessment. Conclusions: Our data validate the newly proposed response to therapy assessment in patients with DTC treated with lobectomy or TT without RAI as an effective tool to modify initial risk estimates of recurrent/persistent SED and better tailor followup and future therapeutic approaches. This study provides further evidence to support a selective use of RAI in DTC.

scholarly journals Thyroglobulin levels before radioactive iodine therapy and dynamic risk stratification after 1 year in patients with differentiated thyroid cancer

2017 ◽  
Vol 61 (6) ◽  
pp. 590-599 ◽  
Author(s):  
Leonardo Bandeira ◽  
Rosália do Prado Padovani ◽  
Ana Luiza Ticly ◽  
Adriano Namo Cury ◽  
Nilza Maria Scalissi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Risk Stratification ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Radioactive Iodine Therapy ◽  
Dynamic Risk

Validation of dynamic risk stratification in pediatric differentiated thyroid cancer

Endocrine ◽  
2017 ◽  
Vol 58 (1) ◽  
pp. 167-175 ◽  
Author(s):  
Seo Young Sohn ◽  
Young Nam Kim ◽  
Hye In Kim ◽  
Tae Hyuk Kim ◽  
Sun Wook Kim ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Risk Stratification ◽  
Differentiated Thyroid Cancer ◽  
Dynamic Risk

Incidence and dynamic risk stratification in differentiated thyroid cancer in a high-resolution clinic, 2002–2017

2021 ◽  
Author(s):  
Gonzalo Díaz-Soto ◽  
Beatriz Torres Torres ◽  
Juan José López ◽  
Susana García ◽  
María Álvarez Quiñones ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
High Resolution ◽  
Risk Stratification ◽  
Differentiated Thyroid Cancer ◽  
Dynamic Risk

scholarly journals A Systematic Review and Metaanalysis of the Effectiveness of Radioactive Iodine Remnant Ablation for Well-Differentiated Thyroid Cancer

2004 ◽  
Vol 89 (8) ◽  
pp. 3668-3676 ◽  
Author(s):  
Anna M. Sawka ◽  
Kullathorn Thephamongkhol ◽  
Melissa Brouwers ◽  
Lehana Thabane ◽  
George Browman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Remnant Ablation ◽  
Well Differentiated

Prediction of radioactive iodine remnant ablation failure in patients with differentiated thyroid cancer: A cohort study of 740 patients

Head & Neck ◽  
2016 ◽  
Vol 39 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Marin Prpic ◽  
Davor Kust ◽  
Ivan Kruljac ◽  
Lora Stanka Kirigin ◽  
Tomislav Jukic ◽  
...  
Keyword(s):  
Cohort Study ◽  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Remnant Ablation
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