A Novel Role for Flotillin-Containing Lipid Rafts in Negative-Feedback Regulation of Thyroid-Specific Gene Expression by Thyroglobulin

Thyroid ◽  
2016 ◽  
Vol 26 (11) ◽  
pp. 1630-1639 ◽  
Author(s):  
Yuqian Luo ◽  
Takeshi Akama ◽  
Akiko Okayama ◽  
Aya Yoshihara ◽  
Mariko Sue ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lipid Rafts ◽  
Negative Feedback ◽  
Feedback Regulation ◽  
Specific Gene ◽  
Negative Feedback Regulation ◽  
Specific Gene Expression

scholarly journals The SUMO ligase Su(var)2-10 controls eu- and heterochromatic gene expression via establishment of H3K9 trimethylation and negative feedback regulation

2019 ◽  
Author(s):  
Maria Ninova ◽  
Baira Godneeva ◽  
Yung-Chia Ariel Chen ◽  
Yicheng Luo ◽  
Sharan J. Prakash ◽  
...  
Keyword(s):  
Gene Expression ◽  
Negative Feedback ◽  
Feedback Regulation ◽  
Specific Gene ◽  
Negative Feedback Regulation ◽  
Tissue Specific ◽  
Tissue Specific Gene ◽  
H3k9 Trimethylation ◽  
Sumo Ligase ◽  
Host Genes

AbstractChromatin is critical for genome compaction and gene expression. On a coarse scale, the genome is divided into euchromatin, which harbors the majority of genes and is enriched in active chromatin marks, and heterochromatin, which is gene-poor but repeat-rich. The conserved molecular hallmark of heterochromatin is the H3K9me3 modification, which is associated with gene silencing. We found that in Drosophila deposition of most of the H3K9me3 mark depends on SUMO and the SUMO-ligase Su(var)2-10, which recruits the histone methyltransferase complex SetDB1/Wde. In addition to repressing repeats, H3K9me3 also influences expression of both hetero- and euchromatic host genes. High H3K9me3 levels in heterochromatin are required to suppress spurious non-canonical transcription and ensure proper gene expression. In euchromatin, a set of conserved genes is repressed by Su(var)2-10/SetDB1-induced H3K9 trimethylation ensuring tissue-specific gene expression. Several components of heterochromatin are themselves repressed by this pathway providing a negative feedback mechanism to ensure chromatin homeostasis.Highlights-Proper expression of host genes residing in heterochromatin requires Su(var)2-10-dependent installation of the H3K9me3 mark to suppress spurious non-canonical transcription.-A set of euchromatic host genes is repressed by transposon-independent installation of H3K9me3 in a process that depends on Su(var)2-10 and SUMO.-Installation of H3K9me3 via Su(var)2-10 ensures tissue-specific gene expression.-H3K9me3-dependent silencing of genes encoding proteins involved in heterochromatin formation provides negative feedback regulation to maintain heterochromatin homeostasis.

scholarly journals The SUMO Ligase Su(var)2-10 Controls Hetero- and Euchromatic Gene Expression via Establishing H3K9 Trimethylation and Negative Feedback Regulation

2020 ◽  
Vol 77 (3) ◽  
pp. 571-585.e4 ◽  
Author(s):  
Maria Ninova ◽  
Baira Godneeva ◽  
Yung-Chia Ariel Chen ◽  
Yicheng Luo ◽  
Sharan J. Prakash ◽  
...  
Keyword(s):  
Gene Expression ◽  
Negative Feedback ◽  
Feedback Regulation ◽  
Negative Feedback Regulation ◽  
H3k9 Trimethylation ◽  
Sumo Ligase

scholarly journals Negative feedback regulation of reactive oxygen species on AT1 receptor gene expression

2000 ◽  
Vol 131 (4) ◽  
pp. 795-803 ◽  
Author(s):  
Georg Nickenig ◽  
Kerstin Strehlow ◽  
Anselm T Bäumer ◽  
Stefanie Baudler ◽  
Sven Waßmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Negative Feedback ◽  
Receptor Gene ◽  
Reactive Oxygen ◽  
Feedback Regulation ◽  
At1 Receptor ◽  
Oxygen Species ◽  
Negative Feedback Regulation ◽  
Receptor Gene Expression

scholarly journals Negative Autoregulation Controls size Scaling in Confined Gene Expression Reactions

2021 ◽  
Author(s):  
Yusuke T. Maeda
Keyword(s):  
Gene Expression ◽  
Negative Feedback ◽  
Regulation Of Gene Expression ◽  
Finite Size ◽  
Feedback Regulation ◽  
Finite Size Effect ◽  
Scaling Relation ◽  
Negative Feedback Regulation ◽  
Cellular Compartment ◽  
Transcriptional Feedback

Abstract Gene expression via transcription-translation is the most fundamental reaction to sustain biological systems, and complex reactions such as this one occur in a small compartment of living cells. Transcriptional feedback that controls gene expression during mRNA synthesis is a vital mechanism that regulates protein synthesis in cells. There is increasing evidence that the cellular compartment induces steric effects in gene expression reactions. However, the finite-size effect of spatial constraints on feedback regulation is not well understood. Here, we study the confinement effect on transcriptional negative feedback regulation of gene expression reactions using a theoretical model. We find that negative feedback regulation alters the scaling relation of gene expression level on compartment volume, approaching the regular scaling relation without the steric effect. Our findings suggest that negative autoregulatory feedback at the transcription step can dampen the size-dependence of protein expression levels in heterogeneous cell populations.

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