Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function

Thyroid ◽  
2016 ◽  
Vol 26 (4) ◽  
pp. 600-609 ◽  
Author(s):  
Flavia F. Bloise ◽  
Anne H. van der Spek ◽  
Olga V. Surovtseva ◽  
Tania Maria Ortiga-Carvalho ◽  
Eric Fliers ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Chronic Inflammation ◽  
Muscle Fiber ◽  
Mitochondrial Function ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Diaphragm Muscle ◽  
Hormone Metabolism ◽  
Differential Effects ◽  
Thyroid Hormone Metabolism

Effect of acute nutritional deprivation on diaphragm structure and function in adolescent rats

1992 ◽  
Vol 73 (3) ◽  
pp. 974-978 ◽  
Author(s):  
M. I. Lewis ◽  
G. C. Sieck
Keyword(s):  
Body Mass ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Structure And Function ◽  
Muscle Fiber Type ◽  
Medial Gastrocnemius ◽  
Diaphragm Muscle ◽  
Nutritional Deprivation ◽  
Ad Libitum ◽  
And Function

The influence of 90 h of acute nutritional deprivation (ND; water ad libitum only) on in vitro contractile and fatigue properties, muscle fiber type proportions, and cross-sectional areas (CSA) of the adolescent rat diaphragm was determined. Diaphragm muscle properties in the ND rats were compared with those in control rats (CTL; food and water ad libitum). Acute ND resulted in a 32% reduction in body mass, whereas the body mass of CTL rats increased by 29%. Acute ND resulted in a significant reduction in the mass of the diaphragm (costal, 36%; crural, 43%), soleus (36%), and medial gastrocnemius (45%) muscles. Isometric twitch characteristics of the diaphragm muscle (contraction and half-relaxation times) were prolonged in the ND animals. Peak twitch and maximum tetanic forces were unaffected by ND. Fatigue resistance of the diaphragm muscle was improved in ND animals. Diaphragm muscle fiber type proportions were similar in ND and CTL groups. The CSA of type I and II diaphragm muscle fibers were reduced by 22 and 40%, respectively, in ND animals compared with CTL. We conclude that, whereas an identical protocol of acute ND had no significant effects on diaphragm muscle structure and function in adult rats, adolescent animals exhibit significantly less nutritional reserve. These differences may be due to curtailment of the rapid anabolic rate in growing animals.

scholarly journals Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/ AMPK circuit

2016 ◽  
Vol 8 (10) ◽  
pp. 1212-1228 ◽  
Author(s):  
Jing Liu ◽  
Xijun Liang ◽  
Danxia Zhou ◽  
Ling Lai ◽  
Liwei Xiao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Mitochondrial Function ◽  
Fiber Type ◽  
Skeletal Muscle Fiber ◽  
Muscle Fiber Type

scholarly journals A Novel Method to Quantify Diaphragm Muscle Fiber Type Clustering in the Context of Sarcopenia

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Amrit Vasdev ◽  
Sarah Greising ◽  
Juan Medina ◽  
Gary Sieck ◽  
Carlos Mantilla
Keyword(s):  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Diaphragm Muscle ◽  
Novel Method

scholarly journals NEUROMUSCULAR TRANSMISSION SAFETY FACTOR VARIES ACROSS DIAPHRAGM MUSCLE FIBER TYPE

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Leonid G Ermilov ◽  
Carlos B Mantilla ◽  
Katharine L Rowley ◽  
Gary C Sieck
Keyword(s):  
Safety Factor ◽  
Muscle Fiber ◽  
Neuromuscular Transmission ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Diaphragm Muscle

scholarly journals Thyroid hormone regulates muscle fiber type conversion via miR-133a1

2014 ◽  
Vol 207 (6) ◽  
pp. 753-766 ◽  
Author(s):  
Duo Zhang ◽  
Xiaoyun Wang ◽  
Yuying Li ◽  
Lei Zhao ◽  
Minghua Lu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Biological Activities ◽  
Slow Muscle ◽  
Muscle Fiber Type ◽  
Epigenetic Mechanism ◽  
Type Conversion ◽  
Muscle Gene Expression

It is known that thyroid hormone (TH) is a major determinant of muscle fiber composition, but the molecular mechanism by which it does so remains unclear. Here, we demonstrated that miR-133a1 is a direct target gene of TH in muscle. Intriguingly, miR-133a, which is enriched in fast-twitch muscle, regulates slow-to-fast muscle fiber type conversion by targeting TEA domain family member 1 (TEAD1), a key regulator of slow muscle gene expression. Inhibition of miR-133a in vivo abrogated TH action on muscle fiber type conversion. Moreover, TEAD1 overexpression antagonized the effect of miR-133a as well as TH on muscle fiber type switch. Additionally, we demonstrate that TH negatively regulates the transcription of myosin heavy chain I indirectly via miR-133a/TEAD1. Collectively, we propose that TH inhibits the slow muscle phenotype through a novel epigenetic mechanism involving repression of TEAD1 expression via targeting by miR-133a1. This identification of a TH-regulated microRNA therefore sheds new light on how TH achieves its diverse biological activities.

scholarly journals Guanidinoacetic Acid Supplementation Promotes Skeletal Muscle Fiber Type Transformation from Fast-to-Slow-Twitch via Increasing the PPARGC1A Based Mitochondrial Function and CaN/NFAT Pathway in Finishing Pigs

Agriculture ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 87
Author(s):  
Jingzheng Li ◽  
Jiaolong Li ◽  
Lin Zhang ◽  
Tong Xing ◽  
Yun Jiang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Mitochondrial Function ◽  
Fiber Type ◽  
Basal Diet ◽  
Skeletal Muscle Fiber ◽  
Muscle Fiber Type ◽  
Finishing Pigs ◽  
Type Transformation ◽  
Slow Twitch

Guanidinoacetic acid can improve pork quality. Previous studies have demonstrated that pork quality is closely linked to the muscle fiber type mediated by PPARGC1A. Therefore, this study aimed to evaluate the influence of dietary GAA supplementation on the skeletal muscle fiber type transformation. A total of 180 healthy Duroc × Landrace × Meishan cross castrated male pigs with a similar average weight (90 ± 1.5 kg) were randomly divided into three treatments with five replicates per treatment and 12 pigs per replicate, including a GAA-free basal diet and basal diet with 0.05% or 0.10% GAA for 15 days. Our results showed that 0.10% GAA supplementation increased the contents of Ca2+ in sarcoplasm (p < 0.05). Compared with the control group, both GAA supplementation groups upregulated the expression of Troponin I-ss (p < 0.05), and 0.10% GAA supplementation downregulated the expression of Troponin T3 (p < 0.05). GAA supplementation increased the expression of peroxisome proliferator activated receptor-γ coactivator-1alpha (PPARGC1A) (p < 0.05), and further upregulated the mitochondrial transcription factor A (TFAM), increased the level of membrane potential, and the activities of mitochondrial respiratory chain complex I, III (p < 0.05). The 0.10% GAA supplementation upregulated the protein expression of calcineurin catalytic subunit α (CnAα) and nuclear factor of activated T cells (NFATc1) (p < 0.05). Overall, dietary GAA supplementation promotes skeletal muscle fiber types transformation from fast-to-slow-twitch via increasing the PPARGC1A based mitochondrial function and the activation of CaN/NFAT pathway in finishing pigs.

scholarly journals Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake

2006 ◽  
Vol 191 (3) ◽  
pp. 707-714 ◽  
Author(s):  
A Boelen ◽  
J Kwakkel ◽  
W M Wiersinga ◽  
E Fliers
Keyword(s):  
Thyroid Hormone ◽  
Food Intake ◽  
Mrna Expression ◽  
Chronic Inflammation ◽  
Paraventricular Nucleus ◽  
Local Inflammation ◽  
Hormone Metabolism ◽  
Thyroid Hormone Metabolism ◽  
Pituitary Thyroid Axis ◽  
Hpt Axis

During illness, changes in thyroid hormone metabolism occur, known as nonthyroidal illness and characterised by decreased serum triiodothyronine (T3) and thyroxine (T4) without an increase in TSH. A mouse model of chronic illness is local inflammation, induced by a turpentine injection in each hind limb. Although serum T3 and T4 are markedly decreased in this model, it is unknown whether turpentine administration affects the central part of the hypothalamus–pituitary–thyroid axis (HPT-axis). We therefore studied thyroid hormone metabolism in hypothalamus and pituitary of mice during chronic inflammation induced by turpentine injection. Using pair-fed controls, we could differentiate between the effects of chronic inflammation per se and the effects of restricted food intake as a result of illness. Chronic inflammation increased interleukin (IL)-1β mRNA expression in the hypothalamus more rapidly than in the pituitary. This hypothalamic cytokine response was associated with a rapid increase in local D2 mRNA expression. By contrast, no changes were present in pituitary D2 expression. TSHβ mRNA expression was altered compared with controls. Comparing chronic inflamed mice with pair-fed controls, both preproTSH releasing hormone (TRH) and D3 mRNA expression in the paraventricular nucleus were significantly lower 48 h after turpentine administration. The timecourse of TSHβ mRNA expression was completely different in inflamed mice compared with pair-fed mice. Turpentine administration resulted in significantly decreased TSHβ mRNA expression only after 24 h while later in time it was lower in pair-fed controls. In conclusion, central thyroid hormone metabolism is altered during chronic inflammation and this cannot solely be attributed to diminished food intake.

scholarly journals AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1

PLoS Genetics ◽  
2021 ◽  
Vol 17 (3) ◽  
pp. e1009488
Author(s):  
Liwei Xiao ◽  
Jing Liu ◽  
Zongchao Sun ◽  
Yujing Yin ◽  
Yan Mao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Mitochondrial Function ◽  
Fiber Type ◽  
Muscle Cells ◽  
Muscle Fiber Type ◽  
Type I ◽  
Loss Of Function ◽  
Interacting Protein ◽  
Ampk Signaling

Mitochondria are essential for maintaining skeletal muscle metabolic homeostasis during adaptive response to a myriad of physiologic or pathophysiological stresses. The mechanisms by which mitochondrial function and contractile fiber type are concordantly regulated to ensure muscle function remain poorly understood. Evidence is emerging that the Folliculin interacting protein 1 (Fnip1) is involved in skeletal muscle fiber type specification, function, and disease. In this study, Fnip1 was specifically expressed in skeletal muscle in Fnip1-transgenic (Fnip1Tg) mice. Fnip1Tg mice were crossed with Fnip1-knockout (Fnip1KO) mice to generate Fnip1TgKO mice expressing Fnip1 only in skeletal muscle but not in other tissues. Our results indicate that, in addition to the known role in type I fiber program, FNIP1 exerts control upon muscle mitochondrial oxidative program through AMPK signaling. Indeed, basal levels of FNIP1 are sufficient to inhibit AMPK but not mTORC1 activity in skeletal muscle cells. Gain-of-function and loss-of-function strategies in mice, together with assessment of primary muscle cells, demonstrated that skeletal muscle mitochondrial program is suppressed via the inhibitory actions of FNIP1 on AMPK. Surprisingly, the FNIP1 actions on type I fiber program is independent of AMPK and its downstream PGC-1α. These studies provide a vital framework for understanding the intrinsic role of FNIP1 as a crucial factor in the concerted regulation of mitochondrial function and muscle fiber type that determine muscle fitness.

Relation of Porcine Muscle Fiber Type and Size to Postmortem Shortening

1971 ◽  
Vol 32 (1) ◽  
pp. 57-61 ◽  
Author(s):  
H. B. Hendricks ◽  
D. T. Lafferty ◽  
E. D. Aberle ◽  
M. D. Judge ◽  
J. C. Forrest
Keyword(s):  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Porcine Muscle
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