scholarly journals Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma

Thyroid ◽  
2015 ◽  
Vol 25 (6) ◽  
pp. 567-610 ◽  
Author(s):  
Samuel A. Wells ◽  
Sylvia L. Asa ◽  
Henning Dralle ◽  
Rossella Elisei ◽  
Douglas B. Evans ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
American Thyroid Association ◽  
Medullary Thyroid

Calcitonin and complementary biomarkers in the diagnosis of hereditary medullary thyroid carcinoma in children and adolescents

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Felix Eckelt ◽  
Roland Pfaeffle ◽  
Wieland Kiess ◽  
Juergen Kratzsch
Keyword(s):  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Medullary Thyroid Carcinoma ◽  
Carbohydrate Antigen ◽  
Good Prognosis ◽  
Laboratory Diagnostics ◽  
American Thyroid Association ◽  
Reference Ranges ◽  
Medullary Thyroid ◽  
Rare Malignancy

Abstract Objectives Medullary thyroid carcinoma (MTC) is a rare malignancy that is effectively curable by surgery. Unlike in adults, hereditary MTC has a predominant role in children. A fast and safe diagnosis is important to assure the good prognosis for the patients. A major cornerstone is the assessment of biomarkers, but the interpretation must respect their pre-, post- and analytical features. Especially calcitonin (Ctn) is a challenging biomarker in daily laboratory diagnostics. However, Ctn is of particular relevance for the diagnostic in MTC. The American Thyroid Association recommends thyroidectomy if the upper reference range of Ctn is exceeded. Interestingly, age-dependent reference ranges for children and adolescents have become available only recently for Ctn assays. With this review, we aim to highlight the importance of a timely diagnosis of MTC in children and adolescents. Content Recent developments in pediatric biochemical diagnostics of MTC were summarized. This includes guidance on interpretation of RET, Ctn, procalcitonin, carcinoembryonic antigen, carbohydrate antigen 19-9, and chromogranin A. Summary Currently, Ctn is the most investigated biomarker in the diagnosis of MTC in children and adolescents. Other biomarkers as PCT suggest complementary evidence about pediatric MTC but their interpretation based largely on adult’s data. A successful treatment of MTC requires, besides results of biomarkers, information about medical history, RET gene analysis and recent guideline knowledge. Outlook More research is required to validate complementary biomarkers of Ctn in children. Additionally, the effect of different confounder on pediatric Ctn levels has to be further clarified.

Abstract #832: Metastatic Medullary Thyroid Carcinoma Presenting as Ectopic Cushing Syndrome

2017 ◽  
Vol 23 ◽  
pp. 179
Author(s):  
Sandeep Donagaon ◽  
Pramila Kalra ◽  
Anil Kumar ◽  
K. Harish ◽  
Shamim Sheik ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cushing Syndrome ◽  
Medullary Thyroid
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