scholarly journals A Potential Role for Immunotherapy in Thyroid Cancer by Enhancing NY-ESO-1 Cancer Antigen Expression

Thyroid ◽  
2014 ◽  
Vol 24 (8) ◽  
pp. 1241-1250 ◽  
Author(s):  
Viswanath Gunda ◽  
Dennie T. Frederick ◽  
Maria J. Bernasconi ◽  
Jennifer A. Wargo ◽  
Sareh Parangi
Keyword(s):  
Thyroid Cancer ◽  
Potential Role ◽  
Antigen Expression ◽  
Cancer Antigen

scholarly journals Neoadjuvant Therapy in Differentiated Thyroid Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Rajan P. Dang ◽  
Daniel McFarland ◽  
Valerie H. Le ◽  
Nadia Camille ◽  
Brett A. Miles ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Neoadjuvant Therapy ◽  
Differentiated Thyroid Cancer ◽  
Potential Role ◽  
Kinase Inhibitors ◽  
Tracheal Resection ◽  
Complete Surgical Resection ◽  
Select Trial ◽  
Short Time

Objectives. Invasion of differentiated thyroid cancer (DTC) into surrounding structures can lead to morbid procedures such as laryngectomy and tracheal resection. In these patients, there is a potential role for neoadjuvant therapy.Methods. We identified three studies involving the treatment of DTC with neoadjuvant chemotherapy: two from Slovenia and one from Japan.Results. These studies demonstrate that in selected situations, neoadjuvant chemotherapy can have a good response and allow for a more complete surgical resection, the treatment of DTC. Additionally, the SELECT trial shows that the targeted therapy lenvatinib is effective in the treatment of DTC and could be useful as neoadjuvant therapy for this disease due to its short time to response. Pazopanib has also demonstrated promise in phase II data.Conclusions. Thus, chemotherapy in the neoadjuvant setting could possibly be useful for managing advanced DTC. Additionally, some of the new tyrosine kinase inhibitors (TKIs) hold promise for use in the neoadjuvant setting in DTC.

scholarly journals Exposure to emissions from Mount Etna (Sicily, Italy) and incidence of thyroid cancer: a geographic analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Paolo Boffetta ◽  
Lorenzo Memeo ◽  
Dario Giuffrida ◽  
Margherita Ferrante ◽  
Salvatore Sciacca
Keyword(s):  
Regression Analysis ◽  
Thyroid Cancer ◽  
Potential Role ◽  
Incidence Rates ◽  
Mount Etna ◽  
Sensitivity Analyses ◽  
Molecular Characteristics ◽  
Special Focus ◽  
Northeastern Sicily

AbstractAn increased incidence of thyroid cancer has been reported in the area close to Mount Etna, the largest volcano in Europe located in Northeastern Sicily. We tested the hypothesis that exposure to the emissions from the volcano is associated with thyroid cancer in 186 municipalities from three provinces surrounding the volcano (1.9 million inhabitants). We measured the angle between the bearing of the municipalities and each direction, with special focus on South-East, the prevalent direction of the plume, and conducted a regression analysis on 2003–2016 incidence rates of thyroid cancer, adjusting for distance from Mount Etna, population size, and income. A 10-degree increase in the angle with South-East was associated with a decrease in thyroid cancer rates in the whole population (− 0.67 cases/100,000, p = 0.002) and in women (− 1.54/100,000, p < 0.001), and were robust to several sensitivity analyses. Similar results were obtained for East-South-East direction. These results support the hypothesis of a potential role of exposure to the plume from Mount Etna in determining the high rates of thyroid cancer. The results need to be confirmed in analytical studies, in which information of exposure to chemicals originating from the volcano, as well as other possible causes, should be carefully measured, molecular characteristics of the tumors and taken into account.

scholarly journals The association between serum TSH concentration and thyroid cancer

2009 ◽  
Vol 16 (4) ◽  
pp. 1065-1072 ◽  
Author(s):  
Kristien Boelaert
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Disease ◽  
Potential Role ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Preoperative Serum ◽  
Lower Baseline ◽  
New Findings ◽  
The Relationship ◽  
Serum Tsh

There is mounting evidence that the serum concentration of TSH is an independent predictor for the diagnosis of thyroid malignancy in patients with nodular thyroid disease. Furthermore, preoperative serum TSH concentrations are higher in patients with more aggressive tumours, suggesting a potential role for TSH in the progression of differentiated thyroid cancer. Based on these observations, patients with higher serum TSH concentrations and borderline cytological results may require more aggressive investigation and treatment when compared with those with lower baseline TSH levels. The mechanisms underlying the finding of higher serum TSH in patients with thyroid cancer remain unexplained. In this issue of Endocrine-Related Cancer, Fiore et al. have analysed the relationship between serum TSH and diagnosis of papillary thyroid cancer in 10 178 patients with nodular thyroid disease who were investigated by fine-needle aspiration biopsy. They found significantly higher TSH concentrations in patients who were subsequently diagnosed with thyroid cancer compared with those with benign disease. In addition, they found that the development of autonomous thyroid function (TSH<0.4 μU/ml) was associated with a reduction in the risk of papillary thyroid carcinoma. In this commentary, the evidence regarding the association between serum TSH and thyroid cancer is discussed placing these new findings into context.

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