Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (Bethesda Category III): Importance of Ultrasonography and Cytological Subcategory

Thyroid ◽  
2014 ◽  
Vol 24 (7) ◽  
pp. 1115-1120 ◽  
Author(s):  
Pedro Weslley Rosario
Keyword(s):  
Thyroid Nodules ◽  
Follicular Lesions ◽  
Undetermined Significance

scholarly journals Malignancy Rate of Bethesda Class III Thyroid Nodules Based on the Presence of Chronic Lymphocytic Thyroiditis in Surgical Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Yoon Young Cho ◽  
Yun Jae Chung ◽  
Hee Sung Kim
Keyword(s):  
Thyroid Nodules ◽  
Chronic Lymphocytic Thyroiditis ◽  
Class Iii ◽  
Lymphocytic Thyroiditis ◽  
Malignancy Rate ◽  
Malignancy Risk ◽  
Follicular Lesions ◽  
Premalignant Condition ◽  
Thyroid Malignancies ◽  
Undetermined Significance

BackgroundHashimoto’s thyroiditis (HT), also known as chronic lymphocytic thyroiditis (CLT), may interfere with the accurate cytological diagnosis of thyroid nodules. Recently, HT has been considered a premalignant condition for thyroid cancer development. The diagnosis of atypia of undetermined significance/follicular lesions of undetermined significance (AUS/FLUS) thyroid nodules is challenging and evidence for the malignancy risk of AUS/FLUS thyroid nodules coexisting with CLT is scarce. Therefore, we assessed the malignancy risk of AUS/FLUS thyroid nodules according to the presence of background CLT.MethodsThis study included 357 surgically resected thyroid nodules with AUS/FLUS cytology. Cases with concomitant malignant nodules were excluded. CLT was defined based on the pathologic report after thyroid surgery.ResultsAmong 357 tumors, 130 tumors (36%) were confirmed to have coexisting CLT, and 170 tumors (48%) were determined to be malignant after thyroidectomy. Malignancy rates were similar in both groups (48% in each) regardless of background CLT (62/130 with CLT vs. 108/227 without CLT). In the group with CLT, thyroiditis was more frequent in the final pathology (12% with CLT vs. 1% without CLT, P = 0.003). In multivariate analysis, positive BRAFV600E mutation, highly suspicious sonographic features (K-TIRADS 5), and smaller thyroid nodules were significant factors for thyroid malignancies.ConclusionThe malignancy rate of thyroid nodules with AUS/FLUS cytology was comparable irrespective of the presence of underlying CLT.

The role of ultrasound findings in the management of thyroid nodules with atypia or follicular lesions of undetermined significance

2013 ◽  
Vol 80 (5) ◽  
pp. 735-742 ◽  
Author(s):  
Won Sang Yoo ◽  
Hoon Sung Choi ◽  
Sun Wook Cho ◽  
Jae Hoon Moon ◽  
Kyung Won Kim ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Ultrasound Findings ◽  
Follicular Lesions ◽  
Undetermined Significance

scholarly journals Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

2015 ◽  
Vol 15 (23) ◽  
pp. 10307-10311 ◽  
Author(s):  
Selami Ilgaz Kayilioglu ◽  
Tolga Dinc ◽  
Isa Sozen ◽  
Kazim Senol ◽  
Kagan Katar ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Follicular Lesions ◽  
Undetermined Significance

Incidence of Malignancy in Thyroid Nodules Determined to be Follicular Lesions of Undetermined Significance on Fine-Needle Aspiration

2011 ◽  
Vol 36 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Gilberto V. Teixeira ◽  
Horacio Chikota ◽  
Thiago Teixeira ◽  
Gabriel Manfro ◽  
Sara I. Pai ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Follicular Lesions ◽  
Undetermined Significance

Thyroid nodules classified as atypia or follicular lesions of undetermined significance deserve further research: Analysis of 305 surgically confirmed nodules

Cytopathology ◽  
2017 ◽  
Vol 28 (5) ◽  
pp. 391-399 ◽  
Author(s):  
S. Turkyilmaz ◽  
M. Ulusahin ◽  
B. Celebi ◽  
A. B. Cekic ◽  
S. Mungan ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Follicular Lesions ◽  
Research Analysis ◽  
Undetermined Significance
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