Thyrotropin Acts as a T-Cell Developmental Factor in Mice and Humans

Thyroid ◽  
2014 ◽  
Vol 24 (6) ◽  
pp. 1051-1061 ◽  
Author(s):  
Kim van der Weerd ◽  
P. Martin van Hagen ◽  
Benjamin Schrijver ◽  
Sjanneke J.W.M. Heuvelmans ◽  
Leo J. Hofland ◽  
...  
Keyword(s):  
T Cell ◽  
Developmental Factor

scholarly journals TCF-1 in CD8 T cells separates GVHD from GVL

2021 ◽  
Author(s):  
Rebecca Harris ◽  
Mahinbanu Mammadli ◽  
Adriana May ◽  
Qi Yang ◽  
Ivan Ting Hin Fung ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Receptor Expression ◽  
Hematopoietic Stem ◽  
Donor Cells ◽  
Donor T Cells ◽  
Life Threatening ◽  
Developmental Factor ◽  
Host Tissues

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematological malignancy due to graft-versus-leukemia (GVL) effects, mediated by alloreactive donor T cells. However, these same donor cells cause graft-versus-host disease (GVHD), a life-threatening complication. During GVHD, donor T cells proliferate, migrate, and produce cytokines, leading to damage of healthy host tissues. Separating the linked processes of GVHD and GVL is critical to improving outcomes. Here we show that TCF-1, a major T cell developmental factor, plays a role in regulation of these processes. Using a mouse model of allo-HSCT leading to GVHD, we found that conditional loss of TCF-1 in mature CD8 T cells separates GVHD from GVL, providing an optimal clinical phenotype. This occurred due to changes in cytokine production, proliferation, cell survival, chemokine receptor expression, and gene expression. Thus, modulation of TCF-1 signaling reduces GVHD severity and persistence, but maintains GVL effects, and could be useful for allo-HSCT or other T cell-mediated disorders. Furthermore, here and in our companion manuscript we show that regulation of mature, alloactivated T cells by TCF-1 differs between CD4 and CD8 T cells, suggesting that TCF-1 is critical for regulation of mature alloactivated T cells, with unique programs in each subset.

Electron microscope study of the secretory activity of epithelial cells in embryonic thymus

1990 ◽  
Vol 48 (3) ◽  
pp. 382-383
Author(s):  
H. Alasam
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Epithelial Cells ◽  
Electron Density ◽  
Secretory Activity ◽  
T Cell Differentiation ◽  
High Electron ◽  
Transmission Electron ◽  
Medullary Epithelial Cells ◽  
Thymic Factor

The possibility that intrathymic T-cell differentiation involves stem cell-lymphoid interactions in embryos led us to study the ultrastructure of epithelial cell in normal embryonic thymus. Studies in adult thymus showed that it produces several peptides that induce T-cell differentiation. Several of them have been chemically characterized, such as thymosin α 1, thymopoietin, thymic humoral factor or the serum thymic factor. It was suggested that most of these factors are secreted by populations of A and B-epithelial cells.Embryonic materials were obtained from inbred matings of Swiss Albino mice. Thymuses were disected from embryos 17 days old and prepared for transmission electron microscopy. Our studies showed that embryonic thymus at this stage contains undifferentiated and differentiated epithelial cells, large lymphoblasts, medium and few small lymphocytes (Fig. 5). No differences were found between cortical and medullary epithelial cells, in contrast to the findings of Van Vliet et al,. Epithelial cells were mostly of the A-type with low electron density in both cytoplasm and nucleus. However few B-type with high electron density were also found (Fig. 7).

FAILURE TO DETECT ANTI-HTLV-1 ANTIBODY IN A PATIENT WITH ADULT T-CELL LEUKAEMIA/LYMPHOMA

1998 ◽  
Vol 103 (4) ◽  
pp. 1207-1208 ◽  
Author(s):  
Shan-Shun Luo ◽  
Hideto Tamura ◽  
Norio Yokose ◽  
Kiyoyuki Ogata ◽  
Kazuo Dan
Keyword(s):  
T Cell ◽  
Cell Leukaemia

Staging laparotomy in cutaneous T-cell disease

1981 ◽  
Vol 117 (9) ◽  
pp. 543-546 ◽  
Author(s):  
J. A. Doyle
Keyword(s):  
T Cell ◽  
Cell Disease ◽  
Staging Laparotomy

Herpes zoster-varicella in cutaneous T-cell lymphomas

1980 ◽  
Vol 116 (4) ◽  
pp. 408-412 ◽  
Author(s):  
E. C. Vonderheid
Keyword(s):  
Herpes Zoster ◽  
T Cell ◽  
T Cell Lymphomas

Positive effects of glucocorticoids on T cell function and development by upregulation of interleukin-7 receptor α

2001 ◽  
Vol 120 (5) ◽  
pp. A314-A315
Author(s):  
D FRANCHIMONT ◽  
J GALON ◽  
M VACCHIO ◽  
R VISCONTI ◽  
G CHROUSOS ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Positive Effects ◽  
Interleukin 7 ◽  
T Cell Function
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