CD3−CD16−CD56bright Immunoregulatory NK Cells are Increased in the Tumor Microenvironment and Inversely Correlate with Advanced Stages in Patients with Papillary Thyroid Cancer

Thyroid ◽  
2013 ◽  
Vol 23 (12) ◽  
pp. 1561-1568 ◽  
Author(s):  
Foteini Gogali ◽  
George Paterakis ◽  
George Z. Rassidakis ◽  
Chrysoula I. Liakou ◽  
Charis Liapi
Keyword(s):  
Thyroid Cancer ◽  
Tumor Microenvironment ◽  
Nk Cells ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Advanced Stages

scholarly journals CXCL10 is a potential biomarker and associated with immune infiltration in human papillary thyroid cancer

2020 ◽  
Author(s):  
Xiao-Jing Qin ◽  
Xu Lin ◽  
Gang Xue ◽  
Hui-Li Fan ◽  
Hao-Yu Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Thyroid Cancer ◽  
Tumor Microenvironment ◽  
Papillary Thyroid Cancer ◽  
Critical Role ◽  
Functional Enrichment ◽  
Detection Methods ◽  
Pathway Enrichment Analysis ◽  
Papillary Thyroid ◽  
Potential Biomarker

Background: In recent years, the annual incidence of thyroid cancer (TC) has increased, with papillary thyroid cancer (PTC) identified as the most common pathological type accounting for about 80% of all thyroid cancer cases. The tumor microenvironment is known to play a vital role in tumor information transmission and immune detection. Methods: In this study, we examined gene expression data from 518 patients with PTC. The ESTIMATE algorithm was used to calculate immune and stromal scores of PTC patients. Based on a protein-protein interaction (PPI) network, functional enrichment and overall survival analyses, C-X-C motif chemokine ligand 10 (CXCL10) was identified as a core gene. We further investigated the roles of core genes of PTC in the tumor immune microenvironment using LinkedOmics, GSEA, and TIMER tools. Results: Immune, stromal and ESTIMATE scores were related to clinicopathological variables of patients with PTC, but not survival outcomes. Eight differentially expressed genes (DEGs) were associated with survival outcome. In addition, immunochemical staining experiments revealed lower expression of CXCL10 in PTC than paracancerous tissues. GSEA pathway enrichment analysis revealed downregulation of CXCL10 in multiple cancer pathways. CXCL10 and related genes were enriched in pathways related to adaptive immune response, cellular defense response and regulation of innate immune response. Conclusion: The tumor microenvironment plays a critical role in development of PTC and CXCL10 may serve as a novel target of precision therapy for this patient population.

scholarly journals Impact of the Tumor Microenvironment on the Gene Expression Profile in Papillary Thyroid Cancer

Pathobiology ◽  
2020 ◽  
Vol 87 (Suppl. 2) ◽  
pp. 143-154 ◽  
Author(s):  
Malgorzata Oczko-Wojciechowska ◽  
Aleksandra Pfeifer ◽  
Michal Jarzab ◽  
Michał Swierniak ◽  
Dagmara Rusinek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Tumor Microenvironment ◽  
Papillary Thyroid Cancer ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Papillary Thyroid

The BRAF V600E mutation in papillary thyroid cancer with positive or suspected pre-surgical cytological finding is not associated with advanced stages or worse prognosis

Endocrine ◽  
2013 ◽  
Vol 45 (3) ◽  
pp. 462-468 ◽  
Author(s):  
Daniele Barbaro ◽  
Roberto Mario Incensati ◽  
Gabriele Materazzi ◽  
Giuseppe Boni ◽  
Mariano Grosso ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Cytological Finding ◽  
Advanced Stages ◽  
Worse Prognosis

Abstract #1086: Patient Experience with Severe Low Energy Following Total Thyroidectomy for Papillary Thyroid Cancer

2017 ◽  
Vol 23 ◽  
pp. 258
Author(s):  
Elizabeth Wendt ◽  
Maria Bates ◽  
Reese Randle ◽  
Jason Orne ◽  
Cameron Macdonald ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Patient Experience ◽  
Low Energy ◽  
Papillary Thyroid
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