Graves' Disease and Toxic Nodular Goiter Are Both Associated with Increased Mortality But Differ with Respect to the Cause of Death: A Danish Population-Based Register Study

Thyroid ◽  
2013 ◽  
Vol 23 (4) ◽  
pp. 408-413 ◽  
Author(s):  
Frans Brandt ◽  
Marianne Thvilum ◽  
Dorthe Almind ◽  
Kaare Christensen ◽  
Anders Green ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Nodular Goiter ◽  
Population Based ◽  
Register Study ◽  
Graves Disease ◽  
Danish Population ◽  
Toxic Nodular Goiter

scholarly journals Cervical cancer survivors and health care use: A Danish population-based register study

2021 ◽  
Vol 161 (2) ◽  
pp. 565-572
Author(s):  
Malene Skorstengaard ◽  
Maria Eiholm Frederiksen ◽  
Miguel Vázquez-Prada Baillet ◽  
Anna-Belle Beau ◽  
Pernille Tine Jensen ◽  
...  
Keyword(s):  
Health Care ◽  
Cervical Cancer ◽  
Cancer Survivors ◽  
Population Based ◽  
Health Care Use ◽  
Register Study ◽  
Danish Population

Mental and behavioural disorders in the children of mothers diagnosed with cancer: A Danish population‐based register study

2018 ◽  
Vol 28 (2) ◽  
pp. 408-414 ◽  
Author(s):  
Natalie C. Momen ◽  
Andreas Ernst ◽  
Linn H. Arendt ◽  
Jørn Olsen ◽  
Jiong Li ◽  
...  
Keyword(s):  
Population Based ◽  
Register Study ◽  
Behavioural Disorders ◽  
Danish Population

Problem Gambling Associated with Violent and Criminal Behaviour: A Danish Population-Based Survey and Register Study

2015 ◽  
Vol 32 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Bjarne Laursen ◽  
Rikke Plauborg ◽  
Ola Ekholm ◽  
Christina Viskum Lytken Larsen ◽  
Knud Juel
Keyword(s):  
Problem Gambling ◽  
Population Based ◽  
Register Study ◽  
Criminal Behaviour ◽  
Danish Population ◽  
Population Based Survey

scholarly journals Radioiodine Treatment of Hyperthyroidism—Prognostic Factors for Outcome

2001 ◽  
Vol 86 (8) ◽  
pp. 3611-3617 ◽  
Author(s):  
Amit Allahabadia ◽  
Jacquie Daykin ◽  
Michael C. Sheppard ◽  
Stephen C. L. Gough ◽  
Jayne A. Franklyn
Keyword(s):  
Single Dose ◽  
Prognostic Factors ◽  
Nodular Goiter ◽  
Fixed Dose ◽  
Graves Disease ◽  
Cure Rate ◽  
Toxic Nodular Goiter ◽  
Large Size ◽  
Lower Cure Rate ◽  
Lower Cure

There is little consensus regarding the most appropriate dose regimen for radioiodine (131I) in the treatment of hyperthyroidism. We audited 813 consecutive hyperthyroid patients treated with radioiodine to compare the efficacy of 2 fixed-dose regimens used within our center (185 megabequerels, 370 megabequerels) and to explore factors that may predict outcome. Patients were categorized into 3 diagnostic groups: Graves’ disease, toxic nodular goiter, and hyperthyroidism of indeterminate etiology. Cure after a single dose of 131I was investigated and defined as euthyroid off all treatment for 6 months or T4 replacement for biochemical hypothyroidism in all groups. As expected, patients given a single dose of 370 megabequerels had a higher cure rate than those given 185 megabequerels, (84.6% vs. 66.6%, P < 0.0001) but an increase in hypothyroidism incidence at 1 yr (60.8% vs. 41.3%, P < 0.0001). There was no difference in cure rate between the groups with Graves’ disease and those with toxic nodular goiter (69.5% vs. 71.4%; P, not significant), but Graves’ patients had a higher incidence of hypothyroidism (54.5% vs. 31.7%, P< 0.0001). Males had a lower cure rate than females (67.6% vs. 76.7%, P = 0.02), whereas younger patients (<40 yr) had a lower cure rate than patients over 40 yr old (68.9% vs. 79.3%, P < 0.001). Patients with more severe hyperthyroidism (P < 0.0001) and with goiters of medium or large size (P < 0.0001) were less likely to be cured after a single dose of 131I. The use of antithyroid drugs, during a period 2 wk before or after 131I, resulted in a significant reduction in cure rate in patients given 185 megabequerels 131I (P < 0.01) but not 370 megabequerels. Logistic regression analysis showed dose, gender, goiters of medium or large size, and severity of hyperthyroidism to be significant independent prognostic factors for cure after a single dose of 131I. We have demonstrated that a single fixed dose of 370 megabequerels 131I is highly effective in curing toxic nodular hyperthyroidism as well as Graves’ hyperthyroidism. Because male patients and those with more severe hyperthyroidism and medium or large-sized goiters are less likely to respond to a single dose of radioiodine, we suggest that the value of higher fixed initial doses of radioiodine should be evaluated in these patient categories with lower cure rates.

SEQUENTIAL OCCURRENCE OF TOXIC NODULAR GOITER FOLLOWED BY GRAVES' DISEASE

1998 ◽  
Vol 4 (3) ◽  
pp. 150-152 ◽  
Author(s):  
Alan H. Seplowitz, MD ◽  
Beth Ann Ditkoff, MD ◽  
Anastasios D. Papadopoulos, MD ◽  
Paul Lo Gerfo, MD
Keyword(s):  
Nodular Goiter ◽  
Graves Disease ◽  
Toxic Nodular Goiter

HLA antigens in Greek patients with thyrotoxicosis (Graves’ disease and toxic nodular goiter)

1984 ◽  
Vol 7 (4) ◽  
pp. 283-286 ◽  
Author(s):  
C. Papasteriades ◽  
Maria N. Alevizaki-Harhalaki ◽  
J. Economidou ◽  
D. G. Ikkos
Keyword(s):  
Hla Antigens ◽  
Nodular Goiter ◽  
Graves Disease ◽  
Toxic Nodular Goiter
Sign in / Sign up

Export Citation Format

Share Document