Riedel's Thyroiditis with Increased IgG4 Plasma Cells: Evidence for an Underlying IgG4-Related Sclerosing Disease?

Thyroid ◽  
2012 ◽  
Vol 22 (9) ◽  
pp. 964-968 ◽  
Author(s):  
Marc Pusztaszeri ◽  
Frederic Triponez ◽  
Jean-Claude Pache ◽  
Massimo Bongiovanni
Keyword(s):  
Plasma Cells ◽  
Riedel’S Thyroiditis ◽  
Riedel's Thyroiditis

scholarly journals Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel’s Thyroiditis?

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
C. A. Simões ◽  
M. R. Tavares ◽  
N. M. M. Andrade ◽  
T. M. Uehara ◽  
R. A. Dedivitis ◽  
...  
Keyword(s):  
Plasma Cells ◽  
Clinical Presentation ◽  
Airway Protection ◽  
High Power Field ◽  
Anterior Neck ◽  
Obliterative Phlebitis ◽  
Riedel’S Thyroiditis ◽  
Storiform Fibrosis ◽  
Riedel's Thyroiditis ◽  
Progressive Enlargement

Riedel’s thyroiditis (RT) represents one type of IgG4-related thyroid disease (IgG4RTD) and the diagnosis involves quantitative immunohistochemistry showing dense lymphoplasmacellular inflammatory infiltrate consisting of IgG4-positive plasma cells with storiform fibrosis and obliterative phlebitis. We report a case of RT with progressive enlargement of the anterior neck, severe dysphagia, odynophagia, and dyspnea. The patient underwent surgical decompression of the airway, protection tracheotomy, and gastrostomy for nutritional intake 6 months after first symptoms. Complete resolution occurred after surgical treatment combined with prednisolone. Immunostaining revealed IgG4-positive plasma cells 12/HPF (high-power field) and the IgG4/IgG ratio 25%, values that were disproportionate to the intensity of the patient’s symptoms. As to this case and the few cases described and analyzed in the literature, our impression is that there is no relation between the intensity of symptoms in RT with the total number of IgG4-positive plasma cells and the IgG4/IgG ratio, but more studies are needed.

Riedel’s thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4 related sclerosing disease?

Thyroid ◽  
2012 ◽  
pp. 120521080945005 ◽  
Author(s):  
Marc Pusztaszeri ◽  
Frederic Triponez ◽  
Jean-Claude Pache ◽  
Massimo Bongiovanni
Keyword(s):  
Plasma Cells ◽  
Riedel’S Thyroiditis ◽  
Riedel's Thyroiditis

MR findings with dynamic evaluation in Riedel's thyroiditis

2002 ◽  
Vol 26 (2) ◽  
pp. 89-91 ◽  
Author(s):  
Naoya Takahashi ◽  
Kouichirou Okamoto ◽  
Kunio Sakai ◽  
Masahiro Kawana ◽  
Motoko Shimada-Hiratsuka
Keyword(s):  
Riedel’S Thyroiditis ◽  
Dynamic Evaluation ◽  
Riedel's Thyroiditis

Riedel’s thyroiditis — Case report and literature review

1994 ◽  
Vol 163 (4) ◽  
pp. 176-177 ◽  
Author(s):  
O. H. Brady ◽  
D. J. Hehir ◽  
S. J. Heffernan
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Riedel’S Thyroiditis ◽  
Riedel's Thyroiditis

scholarly journals Riedel’s thyroiditis as a part of the IgG4 systemic disease: A case report

2021 ◽  
Vol 12 ◽  
pp. 1
Author(s):  
Thamyres Marques ◽  
Bárbara Gehrke ◽  
Francinne Machado Ribeiro ◽  
Marise Machado ◽  
Sérgio de Oliveira Romano ◽  
...  
Keyword(s):  
Case Report ◽  
Systemic Disease ◽  
Riedel’S Thyroiditis ◽  
Riedel's Thyroiditis

scholarly journals Riedel’s thyroiditis associated with mediastinal and retroperitoneal fibrosis

2012 ◽  
Vol 2 (2) ◽  
pp. 200-202
Author(s):  
Said Azzoug ◽  
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Riedel’S Thyroiditis ◽  
Riedel's Thyroiditis

Résumé : La thyroïdite de Riedel est une pathologie fibrosante rare qui s’associe parfois à d’autres pathologies fibrosantes comme rapporté dans l’observation qui suit. Observation : Mme B.F consulte à l’âge de 44 ans pour un goitre de consistance dure pierreuse suspecte ; l’échographie cervicale retrouve un goitre nodulaire calcifié suspect avec des adénopathies satellites, la cytoponction retrouva une hyperplasie lymphoréticulaire non spécifique. La patiente a été opérée retrouvant une thyroïde infiltrant les muscles préthyroïdiens ; les biopsies avec l’étude histologique étaient en faveur d’une thyroïdite de Riedel, la patiente développa par la suite une hypothyroïdie qui fut substituée. Six années plus tard, la patiente développa une toux et un syndrome cave supérieur, le scanner thoracique retrouva un aspect de fibrose médiastinale, la patiente a été mise sous corticoïdes avec une bonne évolution clinique et une stabilisation des lésions sur le plan radiologique. Par la suite, après plusieurs années et suite à des douleurs lombaires droites l’IRM abdominale retrouva une fibrose rétropéritonéale engainant l’uretère droit. Conclusion : La thyroïdite de Riedel s’intègre parfois dans une atteinte fibrosante multi systémique qu’il faudrait rechercher et traiter afin d’améliorer le pronostic du patient.

scholarly journals Riedel's thyroiditis: diagnostic difficulties (clinical case and brief review)

2021 ◽  
pp. 166-171
Author(s):  
A. A. Rybakova ◽  
N. M. Platonova ◽  
T. V. Soldatova ◽  
N. V. Tarbaeva ◽  
T. S. Panevin ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Clinical Case ◽  
Clinical Performance ◽  
Fine Needle Biopsy ◽  
Morphological Description ◽  
Positive Trend ◽  
Riedel’S Thyroiditis ◽  
Compression Syndrome ◽  
Diagnostic Difficulties ◽  
Riedel's Thyroiditis

Riedel's thyroiditis is a rare disease characterized by chronic fibrosis. Clinical performance of this disease is dense stony goiter, which can poorly be displaced during palpation. The overgrowth of the goiter can lead to the development of compression syndrome. To diagnose we need to made fine needle biopsy and made the final diagnose according to its results or according to the morphological description of the postoperative material. An important step in the diagnosis of Riedel's thyroiditis is the determination of serum IgG and IgG4 to exclude an IgG4-associated disease. Treatment of this disease includes drug therapy, which is based on glucocorticosteroids administration or surgical treatment when develops compression syndrome. This article presents a clinical case of a patient with Riedel's thyroiditis; the main complaints were associated with the growth of goiter and the development of compression syndrome. In this regard, patient underwent surgery on the thyroid gland, and after this we get final diagnose. Due to feeling unwell, drug therapy with glucocorticosteroids was prescribed, against the background of which we noted a positive trend.

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