Long-Term Follow-Up of At Least Five Years After Recombinant Human Thyrotropin Compared to Levothyroxine Withdrawal for Thyroid Remnant Ablation with Radioactive Iodine

Thyroid ◽  
2012 ◽  
Vol 22 (3) ◽  
pp. 332-333 ◽  
Author(s):  
Pedro Weslley Rosario ◽  
Augusto Flávio Campos Mineiro Filho ◽  
Rafaela Xavier Lacerda ◽  
Maria Regina Calsolari
Keyword(s):  
Radioactive Iodine ◽  
Thyroid Remnant ◽  
Remnant Ablation ◽  
Long Term Follow Up ◽  
Recombinant Human Thyrotropin

scholarly journals LONG-TERM FOLLOW-UP STUDY OF JUVENILE DIFFERENTIATED THYROID CARCINOMA TREATED BY RADIOACTIVE IODINE

2018 ◽  
pp. 87-95
Author(s):  
J. Mihailovic
Keyword(s):  
Prognostic Factors ◽  
Initial Treatment ◽  
Radioactive Iodine ◽  
Recurrent Disease ◽  
Differentiated Thyroid Carcinoma ◽  
Follow Up Study ◽  
Tumor Multifocality ◽  
Long Term Follow Up

The overall prognosis in pediatric differentiated thyroid carcinoma (DTC) is excellent. Recurrent disease is frequent, however, and requires additional treatment. In this study we retrospectively analyzed the outcome of juvenile DTC treated by radioactive iodine (I-131) during the long-term follow-up study of 29 years. Methods: 54 DTC patients (34 females, 20 males; ≤20 years old, mean age, 16,5 years) were treated with 131I (RAI) with a median follow-up of 13 years. Patients (pts) underwent different initial treatment: 49 pts, TTx+RAI; 2 pts, TTx; and 3 pts, STTx. The probability of recurrence and prognostic factors were tested by Kaplan-Meier’s method. Results: Initially, 37/54 pts achieved complete remission (CR), 16/54 pts partial remission (PR), 1/54 had progressive disease (PG). During the follow-up 11 pts (20,4%) who achieved CR developed recurrent disease (RD); median appearance time, 4 years (range, 1–25 years). Probability of recurrence was 15,8% at 5 years; 20,3% at 10 years, 25,6% at 15, 20 and 26 years after initial treatment. Strong predictive factors of recurrence were age (p=0,0001), initial treatment (p=0,0001), and tumor multifocality (p=0,004), while gender, nodal metastases at presentation, distal metastases at presentation, histological type of the tumor, tumor or T stage and clinical stage showed no influence on relapse (p=0,176; p=0,757; p=0,799; and p=0,822, respectively). Patients with RD, PR and PG were retreated, with surgery or surgery plus RAI, receiving cumulative activity up to 40 GBq. The overall outcome in our patients was excellent: 88,9% CR, 5,55% SD, 1,85% PG, 1,85% DRD, and 1,85% OCD. Conclusion: Younger age at diagnosis, less radical primary surgery without subsequent RAI, and tumor multifocality are strong prognostic factors for recurrence. In order to reduce relapse rate and to improve surveillance for recurrent disease, TTx followed by RAI appears to be the most beneficial initial treatment for patients with juvenile DTC. The use of RAI seems to be safe without adverse effects on subsequent fertility and pregnancy or secondary malignancy.

Iodine Nutrition and the Risk from Radioactive Iodine: A Workshop Report in the Chernobyl Long-Term Follow-Up Study

Thyroid ◽  
2001 ◽  
Vol 11 (5) ◽  
pp. 487-491 ◽  
Author(s):  
Jacob Robbins ◽  
John T. Dunn ◽  
Andre Bouville ◽  
Victor I. Kravchenko ◽  
Jay Lubin ◽  
...  
Keyword(s):  
Radioactive Iodine ◽  
Iodine Nutrition ◽  
Workshop Report ◽  
Follow Up Study ◽  
Long Term Follow Up

scholarly journals The diagnostic challenge of coexistent sarcoidosis and thyroid cancer – a retrospective study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Vera Wenter ◽  
Nathalie L. Albert ◽  
Freba Ahmaddy ◽  
Marcus Unterrainer ◽  
Julia Hornung ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Radioactive Iodine ◽  
Clinical Course ◽  
Diagnostic Challenge ◽  
Long Term Follow Up ◽  
Tc 11 ◽  
Work Up

Abstract Background Sarcoid lesions may mimic metastatic disease or recurrence in thyroid cancer (TC) patients as both diseases may affect the lungs and lymph nodes. We present the first study to systematically evaluate the clinical course of patients with (TC) after adjuvant radioactive iodine therapy (RIT) and concomitant sarcoidosis of the lung or the lymph nodes. Methods We screened 3285 patients and retrospectively identified 16 patients with TC (11 papillary thyroid cancer (PTC), 3 follicular thyroid cancer (FTC), 1 oncocytic PTC, 1 oncocytic FTC) and coexisting sarcoidosis of the lung and/or the lymph nodes treated at our institute. All patients had undergone thyroidectomy and initial adjuvant RIT. Challenges in diagnosing and the management of these patients were evaluated during long term follow-up (median 4.9 years (0.8–15.0 years)). Results Median age at first diagnosis of TC was 50.1 years (33.0–71.5 years) and of sarcoidosis 39.4 years (18.0–63.9 years). During follow-up, physicians were able to differentiate between SA and persistent or recurrent TC in 10 of 16 patients (63%). Diagnosis was complicated by initial negative thyroglobulin (Tg), positive Tg antibodies and non-specific imaging findings. Histopathology can reliably distinguish between SA and TC in patients with one suspicious lesion. Conclusion Physicians should be aware of the rare coexistence of sarcoidosis and TC. Lymphadenopathy and pulmonary lesions could be metastases, sarcoidosis or even a mix of both. Therefore, this rare patient group should receive a thorough work up including histopathological clarification and, if necessary, separately for each lesion.

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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