Observations on the Proposed “Nonclassical” Model of Autoimmune Hypothyroidism

Thyroid ◽  
2010 ◽  
Vol 20 (6) ◽  
pp. 665-666 ◽  
Author(s):  
Yuji Nagayama
Keyword(s):  
Autoimmune Hypothyroidism ◽  
Nonclassical Model

scholarly journals A Nonclassical Model of Autoimmune Hypothyroidism

Thyroid ◽  
2010 ◽  
Vol 20 (1) ◽  
pp. 3-5 ◽  
Author(s):  
Patrizio Caturegli ◽  
Hiroaki Kimura
Keyword(s):  
Autoimmune Hypothyroidism ◽  
Nonclassical Model

An unusual association with autoimmune hypothyroidism

2013 ◽  
pp. 1-1
Author(s):  
Louise Overend ◽  
Niall Furlong ◽  
Steven McNulty
Keyword(s):  
Autoimmune Hypothyroidism ◽  
Unusual Association

Case of TSH secreating pituitary adenoma (TSHOMA) where course was modified by coexistant autoimmune hypothyroidism

2017 ◽  
Author(s):  
Ameya Joshi ◽  
Rajesh Ghagre ◽  
Premlata Varthakavi ◽  
Pradeep Dalwadi ◽  
Nikhil Bhagwat
Keyword(s):  
Pituitary Adenoma ◽  
Autoimmune Hypothyroidism

scholarly journals Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children

2021 ◽  
pp. 1-7
Author(s):  
Luana da Silva Chagas ◽  
Poliana Capucho Sandre ◽  
Patricia Coelho de Velasco ◽  
Henrique Marcondes ◽  
Natalia Cristina Aparecida Ribeiro e Ribeiro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Brain Development ◽  
Neural Development ◽  
Viral Infections ◽  
Additional Risk ◽  
Autoimmune Hypothyroidism ◽  
Inflammatory Syndrome ◽  
Nutritional Imbalance ◽  
Synaptic Pruning

COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) betacoronavirus, affects children in a different way than it does in adults, with milder symptoms. However, several cases of neurological symptoms with neuroinflammatory syndromes, such as the multisystem inflammatory syndrome (MIS-C), following mild cases, have been reported. As with other viral infections, such as rubella, influenza, and cytomegalovirus, SARS-CoV-2 induces a surge of proinflammatory cytokines that affect microglial function, which can be harmful to brain development. Along with the viral induction of neuroinflammation, other noninfectious conditions may interact to produce additional inflammation, such as the nutritional imbalance of fatty acids and polyunsaturated fatty acids and alcohol consumption during pregnancy. Additionally, transient thyrotoxicosis induced by SARS-CoV-2 with secondary autoimmune hypothyroidism has been reported, which could go undetected during pregnancy. Together, those factors may pose additional risk factors for SARS-CoV-2 infection impacting mechanisms of neural development such as synaptic pruning and neural circuitry formation. The present review discusses those conditions in the perspective of the understanding of risk factors that should be considered and the possible emergence of neurodevelopmental disorders in COVID-19-infected children.

Primary Hyperaldosteronism Associated with Vitiligo Vulgaris and Autoimmune Hypothyroidism

2007 ◽  
Vol 333 (3) ◽  
pp. 178-180 ◽  
Author(s):  
Maria José Molina-Garrido ◽  
Carmen Guillen-Ponce ◽  
Ricardo Enríquez ◽  
Ana Esther Sirvent ◽  
Antonia Mora-Rufete
Keyword(s):  
Primary Hyperaldosteronism ◽  
Autoimmune Hypothyroidism

scholarly journals Link between autoimmune hypothyroidism and polycystic ovary syndrome.

2020 ◽  
Vol 27 (09) ◽  
pp. 1804-1808
Author(s):  
Anam Rehman ◽  
Shireen Jawed ◽  
Amna Rashid Tariq
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Function ◽  
Polycystic Ovary ◽  
Thyroid Autoimmunity ◽  
Study Groups ◽  
Thyroid Peroxidase ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Autoimmune Hypothyroidism ◽  
Thyroid Peroxidase Antibody

Objectives: Polycystic ovary syndrome (PCOS) is a rampant endocrine disorder distressing women of child bearing age worldwide. Many current researches have detected the presence of some organ specific and non-specific autoantibodies in females with PCOS. Study Design: Cross Sectional study. Setting:  Aziz Fatimah Hospital, Faisalabad, Pakistan. Period: April to September 2017. Material & Methods: This study comprised of 88 female subjects of 17-35 years old. Participants were divided into four group’s i.e PCOS obese females, PCOS non-obese, obese females without PCOS and age matched controls. Thyroid function was evaluated by the measurement of serum TSH, FT3 and FT4 levels. Thyroid peroxidase antibody was detected as an indicator of thyroid autoimmunity. All parameters were measured by chemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis of the data. Results: Out of total 88 female participants, 38.6% were hypothyroid and 61.4% were euthyroid females. While on comparing the percentages of hypothyroidism among the study groups PCOS, non-PCOS patients and obese we found higher percentages of hypothyroidism among non-obese PCOS. Thyroid peroxidase antibody levels were higher in PCOS obese subjects. PCOS patients have 15 times more risk for hypothyroidism as compared to non-PCOS patients. Conclusion: Hypothyroidism was commonly found in PCOS patients with high levels of TPO-Antibody indicating that PCOS is an independent risk factor for hypothyroidism which suggests that evaluation of thyroid function and autoimmunity must be deliberated in PCOS patients.

scholarly journals SAT-509 Sudden Onset of Malabsorption

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Gabriela Mroueh ◽  
James K Burks
Keyword(s):  
Medication Adherence ◽  
The Elderly ◽  
Sudden Onset ◽  
Primary Hypothyroidism ◽  
Caucasian Woman ◽  
Thyroid Function Tests ◽  
Autoimmune Hypothyroidism ◽  
High Clinical Suspicion ◽  
Immune Mediated ◽  
History Of

Abstract Celiac disease (CD) is an immune-mediated enteropathy caused by a reaction to gliadin which responds to a restriction to dietary gluten. It has been traditionally recognized in children and young adults, although, recently, detection in the elderly population has increased. CD occurs in 2–5% of patients with autoimmune hypothyroidism, and is more prevalent in this group than in the general population An 82-year-old Caucasian woman with primary hypothyroidism and a BMI of 16 is referred to our endocrinology clinic for help with the management of hypothyroidism. She had a history of well controlled hypothyroidism on weight-dosed levothyroxine for many years until several months prior when she developed sudden onset of diarrhea and weight loss. Since then, her thyroid function tests showed an elevated TSH despite medication adherence. Her levothyroxine dose was steadily increased to 300 mcg daily and yet, her TSH still remained elevated. Laboratory work up was done which revealed elevated transglutaminase antibodies, suggesting the diagnosis of CD. The patient refused an endoscopy for a tissue diagnosis. Even though the patient has been diagnosed with CD, she has trouble following a gluten free diet and still has intermittent diarrhea and high levothyroxine requirements. Although lack of medication adherence is common, it is important to exclude gastric or intestinal causes of malabsorption in patients with high thyroid replacement requirements. Elderly patients often have paucity of symptoms, so high clinical suspicion is necessary to diagnose these patients.

SELF-REPORTED ALLERGY TO THYROID REPLACEMENT THERAPY: A MULTICENTER RETROSPECTIVE CHART REVIEW

2020 ◽  
Vol 26 (7) ◽  
pp. 761-767
Author(s):  
Natalia Chamorro-Pareja ◽  
Ismael Carrillo-Martin ◽  
Daniela A. Haehn ◽  
Sydney A. Westphal ◽  
Miguel A. Park ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Replacement Therapy ◽  
Chart Review ◽  
Case Reports ◽  
Drug Hypersensitivity ◽  
Retrospective Chart Review ◽  
The United States ◽  
Autoimmune Hypothyroidism ◽  
Drug Hypersensitivity Reaction

Objective: To determine patterns of adverse drug reactions (ADRs), including immediate drug hypersensitivity reactions (DHRs) and predictable ADRs, to thyroid replacement therapy (TRT). TRT is the treatment of choice for hypothyroidism. Levothyroxine (LT4) is among the most commonly prescribed medications in the United States, with over 70 million prescriptions annually. Documented immediate DHRs to TRT are rare, with only a few case reports. Methods: An 11-year (2008–2018) retrospective medical chart review of identified patients with self-reported allergy to TRT. ADRs to TRT were divided into immediate DHRs and predictable ADRs. Results: A total of 466 patients were included in our study. We found an overall incidence of ADRs to TRT of 0.3%. Median age was 61.2 years; 85.8% were women, and 94.4% were Caucasian. The principal indication for TRT was autoimmune hypothyroidism (73.6%), followed by postsurgical hypothyroidism (17.4%) and subclinical hypothyroidism (6.7%). Predictable ADR manifestations to TRT were reported more commonly than DHR manifestations (57.5% vs. 42.5%, respectively). The most frequently reported of the former were palpitations (16.4%), nausea/vomiting (9.3%), and tremor (6.3%), while rash (23.8%), hives (9.5%), and pruritus (7.1%) were the most common regarding the latter. Fifty-six percent of the patients with an ADR to TRT tolerated an alternative TRT presentation. Conclusion: In our cohort, the majority of self-reported allergies to TRT were due to predictable ADRs rather than an immediate DHR. Abbreviations: ADR = adverse drug reaction; DHR = drug hypersensitivity reaction; FDA = Food and Drug Administration; LT3 = liothyronine; LT4 = levothyroxine; SCAR = severe cutaneous adverse drug reaction; TRT = thyroid replacement therapy

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