CXC Chemokine Receptor 4 Immunodetection in the Follicular Variant of Papillary Thyroid Carcinoma: Comparison to Galectin-3 and Hector Battifora Mesothelial Cell-1

Thyroid ◽  
2010 ◽  
Vol 20 (5) ◽  
pp. 495-504 ◽  
Author(s):  
Liborio Torregrossa ◽  
Pinuccia Faviana ◽  
Maria Elena Filice ◽  
Gabriele Materazzi ◽  
Paolo Miccoli ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Chemokine Receptor ◽  
Mesothelial Cell ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
Galectin 3 ◽  
Chemokine Receptor 4

scholarly journals Galectin-3 Immunohistochemical Expression in Thyroid Neoplasms – A Study from Kalaburagi, Karnataka

2021 ◽  
Vol 8 (26) ◽  
pp. 2288-2293
Author(s):  
Anuradha G. Patil ◽  
Saniya Jahan ◽  
Syed Mukhtar Mohiuddin
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Thyroid Neoplasms ◽  
Malignant Neoplasms ◽  
Benign Neoplasms ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Galectin 3 ◽  
Malignant Thyroid Neoplasms

BACKGROUND Thyroid carcinoma is the most common endocrine malignancy. Galectin-3 has been implicated in malignant transformation and metastasis of cancer cells and it has received notable recognition for its usefulness as a diagnostic marker for thyroid cancer. We wanted to evaluate the expression of Galectin-3 on thyroid neoplasms, establish its diagnostic accuracy and also differentiate between benign and malignant thyroid lesions. METHODS A total of 54 thyroidectomy specimens were studied over a period of 3 years (2016 - 2019) which included 20 benign and 34 malignant thyroid neoplasms. Histopathologic evaluation of H & E stained sections was done and immunohistochemistry (IHC) staining for Galectin-3 was performed for all neoplasms with the polymeric method using lyophilized mouse monoclonal antibody. (Path n Situ) and grading based on intensity of Galectin-3 expression were noted. RESULTS Galectin-3 expression was significantly higher (P < 0.001) in malignant thyroid neoplasms in comparison to the benign neoplasms. Galectin-3 expression for malignant neoplasms showed sensitivity of 88.23 %, specificity of 95.0 %, positive predictive value (PPV) of 96.8 % and negative predictive value (NPV) of 82.6 %. Galectin-3 expression in Papillary thyroid carcinoma showed a sensitivity of 95.83 % and PPV of 88.2 %. While comparing the neoplasms showing follicular pattern, Galectin-3 expression was more in the malignant neoplasms (follicular carcinoma and follicular variant of papillary carcinoma thyroid) than benign neoplasms (follicular adenoma). CONCLUSIONS Galectin-3 is a useful marker in differentiating benign and malignant thyroid neoplasms. Galectin-3 is sensitive for Papillary thyroid carcinoma (PTC) and among the follicular patterned lesions, Galectin-3 is sensitive for follicular variant of papillary carcinoma and follicular carcinoma. Thus Galectin-3 protein expression evaluated using immunohistochemistry technique acts as an adjunctive ancillary technique in thyroid cancer diagnosis. KEYWORDS Galectin-3, Immunohistochemistry, Thyroid Carcinoma, Papillary Thyroid Carcinoma

Follicular thyroid carcinoma and follicular variant papillary thyroid carcinoma: Clinical and histological features depending on the initial size

2017 ◽  
Author(s):  
Fernando Garcia Perez ◽  
Guillermo Martinez de Pinillos Gordillo ◽  
Mariana Tome Fernandez-Ladreda ◽  
Eyvee Arturo Cuellar Lloclla ◽  
Jose Alvaro Romero Porcel ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Initial Size ◽  
Histological Features

A Greek Family with a Follicular Variant of Familial Papillary Thyroid Carcinoma: TCO, MNG1, fPTC/PRN, and NMTC1 Excluded as Susceptibility Loci

Thyroid ◽  
2005 ◽  
Vol 15 (12) ◽  
pp. 1349-1354 ◽  
Author(s):  
Tasoula Tsilchorozidou ◽  
Eleni Vafiadou ◽  
John G. Yovos ◽  
Giovani Romeo ◽  
James McKay ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Susceptibility Loci ◽  
Follicular Variant

CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type

2007 ◽  
Vol 56 (10) ◽  
pp. 1589-1595 ◽  
Author(s):  
Stefania Scala ◽  
Caterina Ieranò ◽  
Alessandro Ottaiano ◽  
Renato Franco ◽  
Anna La Mura ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Chemokine Receptor ◽  
Cell Type ◽  
Mixed Cell ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
Uveal Malignant Melanoma ◽  
Chemokine Receptor 4

scholarly journals Cutaneous metastases on the head and neck from a papillary thyroid carcinoma, follicular variant

2016 ◽  
Vol 107 (1) ◽  
pp. 83-85
Author(s):  
A. Márquez García ◽  
L. Ferrándiz Pulido ◽  
J.J. Ríos-Martín ◽  
F.M. Camacho Martínez
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Head And Neck ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Cutaneous Metastases
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