Copy Number and Gene Expression Alterations in Radiation-Induced Papillary Thyroid Carcinoma from Chernobyl Pediatric Patients

Thyroid ◽  
2010 ◽  
Vol 20 (5) ◽  
pp. 475-487 ◽  
Author(s):  
Leighton Stein ◽  
Jenniffer Rothschild ◽  
Jesse Luce ◽  
John K. Cowell ◽  
Geraldine Thomas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Copy Number ◽  
Pediatric Patients ◽  
Papillary Thyroid ◽  
Radiation Induced ◽  
Gene Expression Alterations

Large contribution of copy number alterations in early stage of Papillary Thyroid Carcinoma

2021 ◽  
pp. 104584
Author(s):  
Nazanin Hosseinkhan ◽  
Maryam Honardoost ◽  
Kevin Blighe ◽  
C.B.T. Moore ◽  
Mohammad E. Khamseh
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Copy Number ◽  
Early Stage ◽  
Large Contribution ◽  
Papillary Thyroid ◽  
Copy Number Alterations

Thyroid Lobectomy for T1 Papillary Thyroid Carcinoma in Pediatric Patients

2021 ◽  
Author(s):  
Chad K. Sudoko ◽  
Carolyn M. Jenks ◽  
Andrew J. Bauer ◽  
Amber Isaza ◽  
Sogol Mostoufi-Moab ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Pediatric Patients ◽  
Papillary Thyroid ◽  
Thyroid Lobectomy

scholarly journals TERT Promoter Mutations and Their Impact on Gene Expression Profile in Papillary Thyroid Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1597 ◽  
Author(s):  
Dagmara Rusinek ◽  
Aleksandra Pfeifer ◽  
Marta Cieslicka ◽  
Malgorzata Kowalska ◽  
Agnieszka Pawlaczek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Distant Metastases ◽  
Gene Set Enrichment Analysis ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Mutational Status

Background: Telomerase reverse transcriptase promoter (TERTp) mutations are related to a worse prognosis in various malignancies, including papillary thyroid carcinoma (PTC). Since mechanisms responsible for the poorer outcome of TERTp(+) patients are still unknown, searching for molecular consequences of TERTp mutations in PTC was the aim of our study. Methods: The studied cohort consisted of 54 PTCs, among them 24 cases with distant metastases. BRAF V600E, RAS, and TERTp mutational status was evaluated in all cases. Differences in gene expression profile between TERTp(+) and TERTp(−) PTCs were examined using microarrays. The evaluation of signaling pathways and gene ontology was based on the Gene Set Enrichment Analysis. Results: Fifty-nine percent (32/54) of analyzed PTCs were positive for at least one mutation: 27 were BRAF(+), among them eight were TERTp(+), and 1 NRAS(+), whereas five other samples harbored RAS mutations. Expression of four genes significantly differed in BRAF(+)TERTp(+) and BRAF(+)TERTp(−) PTCs. Deregulation of pathways involved in key cell processes was observed. Conclusions: TERTp mutations are related to higher PTC aggressiveness. CRABP2 gene was validated as associated with TERTp mutations. However, its potential use in diagnostics or risk stratification in PTC patients needs further studies.

scholarly journals Telomere Length and Telomerase Reverse Transcriptase Gene Copy Number in Patients with Papillary Thyroid Carcinoma

2011 ◽  
Vol 96 (11) ◽  
pp. E1876-E1880 ◽  
Author(s):  
Jaroslaw Jendrzejewski ◽  
Jerneja Tomsic ◽  
Gerard Lozanski ◽  
Jadwiga Labanowska ◽  
Huiling He ◽  
...  
Keyword(s):  
Gene Expression ◽  
Papillary Thyroid Carcinoma ◽  
Telomere Length ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Telomerase Reverse Transcriptase ◽  
Papillary Thyroid ◽  
Quantitative Real Time Pcr ◽  
Tert Gene

Abstract Context: The family risk ratio for papillary thyroid carcinoma (PTC) is among the highest of all cancers. Collectively, familial cases (fPTC) and sporadic cases (sPTC) are not known to show molecular differences. However, one study reported that telomeres were markedly shorter and the telomerase reverse transcriptase (TERT) gene was amplified and up-regulated in germline DNA from patients with fPTC compared with sPTC. Objective: The aim of this study was to evaluate telomere length and TERT gene amplification and expression in blood samples of fPTC and sPTC patients in a genetically distinct population from the previous study. Design: In 42 fPTC and 65 sPTC patients, quantitative real-time PCR was employed to measure the relative telomere length (RTL) and TERT gene copy number and RNA level. To validate the results using alternative methods, we further studied a subset of the original cohort consisting of randomly chosen fPTC (n = 10) and sPTC (n = 14) patients and controls (n = 21) by assessing both telomere length by flow fluorescent in situ hybridization and TERT gene expression by quantitative real-time PCR. Results: RTL and TERT gene copy number did not differ between fPTC and sPTC (P = 0.957 and P = 0.998, respectively). The mean RTL and TERT gene expression were not significantly different among the groups of the validation series (P = 0.169 and P = 0.718, respectively). Conclusion: Our data show no difference between familial and sporadic PTC with respect to telomere length, TERT copy number, or expression in our cohort. Further investigations in additional cohorts of patients are desirable.

scholarly journals Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

2001 ◽  
Vol 98 (26) ◽  
pp. 15044-15049 ◽  
Author(s):  
Y. Huang ◽  
M. Prasad ◽  
W. J. Lemon ◽  
H. Hampel ◽  
F. A. Wright ◽  
...  
Keyword(s):  
Gene Expression ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid

593 Gene expression profilling in papillary thyroid carcinoma: Are there different pathways of carcinogenesis?

2003 ◽  
Vol 1 (5) ◽  
pp. S179
Author(s):  
B. Jarzab ◽  
M. Wiench ◽  
J. Wloch ◽  
K. Fujarewicz ◽  
K. Simek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid
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