Arterial Stiffness but Not Intima-Media Thickness Is Increased in Euthyroid Patients with Hashimoto's Thyroiditis: The Effect of Menopausal Status

Thyroid ◽  
2009 ◽  
Vol 19 (8) ◽  
pp. 857-862 ◽  
Author(s):  
Kimon S. Stamatelopoulos ◽  
Katerina Kyrkou ◽  
Elda Chrysochoou ◽  
Helen Karga ◽  
Sofia Chatzidou ◽  
...  
2015 ◽  
Vol 12 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Murat Çiftel ◽  
Berrin Demir ◽  
Günay Kozan ◽  
Osman Yılmaz ◽  
Hasan Kahveci ◽  
...  

2021 ◽  
pp. 074823372110316
Author(s):  
Nina L Stute ◽  
Jonathon L Stickford ◽  
Marc A Augenreich ◽  
Kyle C Kimball ◽  
Janet M Cope ◽  
...  

Formaldehyde (FA) is a ubiquitous organic preservative used in several industries and represents an occupational health hazard. Short-term exposure to FA can increase oxidative stress and cause a decrease in conduit vessel function. These decrements in vascular function may extend to the arterial architecture, predisposing individuals to increased risk of cardiovascular disease. The purpose of this study was to investigate the impact of an acute 90-minute FA exposure period (259 ± 95 ppb) on indices of arterial architecture. Arterial stiffness and carotid distensibility as determined by central pressures, augmentation index (AIx), and carotid-femoral pulse wave velocity (cfPWV) ( n=13F, 24 ± 1 year) as well as carotid stiffness and intima media thickness (IMT) ( n = 9F, 23 ± 1 year) were assessed prior to (Pre-FA) and immediately following (Post-FA) exposure to FA in human cadaver dissection laboratories. Central pressures and cfPWV (Pre-FA: 5.2 ± 0.8 m.s−1, Post-FA: 5.2 ± 1.1 m s−1) were unchanged by acute FA exposure ( p > 0.05). Carotid stiffness parameters and distension were unchanged by acute FA exposure ( p > 0.05), although distensibility (Pre-FA: 33.9 ± 10.5[10–3*kPa−1], Post-FA: 25.9 ± 5.5[10–3*kPa-1], p < 0.05), and IMT (Pre-FA: 0.42 ± 0.05 mm, Post-FA: 0.51 ± 0.11 mm, p < 0.05) decreased and increased, respectively. Individual Pre- to Post-FA changes in these markers of arterial architecture did not correlate with levels of FA exposure ([FA]: 20–473 ppb) ( p > 0.05). Our group previously found vascular function decrements following acute FA exposure in human cadaver laboratories; here we found that carotid distensibility and intima media thickness are altered following FA exposure.


2012 ◽  
Vol 3 ◽  
pp. 484-490 ◽  
Author(s):  
Anita Rogowicz-Frontczak ◽  
Aleksandra Araszkiewicz ◽  
Stanislaw Pilacinski ◽  
Dorota Zozulinska-Ziolkiewicz ◽  
Andrzej Wykretowicz ◽  
...  

2013 ◽  
Vol 108 (2) ◽  
pp. S95-S96
Author(s):  
Raymond Wang ◽  
Elizabeth Braunlin ◽  
Kelly Covault ◽  
Andrea Metzig ◽  
Kyle Rudser ◽  
...  

2019 ◽  
Vol 4 ◽  
pp. 154 ◽  
Author(s):  
Li Yan ◽  
Ellison Carter ◽  
Yu Fu ◽  
Dongshuang Guo ◽  
Pinchun Huang ◽  
...  

Background: Unfavourable blood pressure (BP) level is an established risk factor for cardiovascular diseases (CVD), while the exact underlying reasons for unfavourable BP are poorly understood.  The INTERMAP China Prospective (ICP) Study is a prospective cohort to investigate the relationship of environmental and nutritional risk factors with key indicators of vascular function including BP, arterial stiffness, and carotid-intima media thickness. Methods: A total of 839 Chinese participants aged 40-59 years from three diverse regions of China were enrolled in INTERMAP in 1997/98; data collection included repeated BP measurements, 24-hour urine specimens, and 24-hour dietary recalls.  In 2015/16, 574 of these 839 persons were re-enrolled along with 208 new participants aged 40-59 years that were randomly selected from the same study villages.  Participant’s environmental and dietary exposures and health outcomes were assessed in this open cohort study, including BP, 24-hour dietary recalls, personal exposures to air pollution, grip strength, arterial stiffness, carotid-media thickness and plaques, cognitive function, and sleep patterns.  Serum and plasma specimens were collected with 24-hour urine specimens. Discussion:  Winter and summer assessments of a comprehensive set of vascular indicators and their environmental and nutritional risk factors were conducted with high precision.  We will leverage advances in exposome research to identify biomarkers of exposure to environmental and nutritional risk factors and improve our understanding of the mechanisms and pathways of their hazardous cardiovascular effects.  The ICP Study is observational by design, thus subject to several biases including selection bias (e.g., loss to follow-up), information bias (e.g., measurement error), and confounding that we sought to mitigate through our study design and measurements.  However, extensive efforts will apply to minimize those limitations (continuous observer training, repeated measurements of BP, standardized methods in data collection and measurements, and on-going quality control).


Rheumatology ◽  
2020 ◽  
Vol 59 (10) ◽  
pp. 2881-2892
Author(s):  
Isaac T Cheng ◽  
Edmund K Li ◽  
Priscilla C Wong ◽  
Mei Yan Law ◽  
Isaac C Yim ◽  
...  

Abstract Objective PsA patients who achieved sustained minimal disease activity (sMDA) had less subclinical atherosclerosis progression. The vascular effects of achieving other potential treatment targets, including the PsA Disease Activity Score (PASDAS) and the Disease Activity in PsA (DAPSA) score, remained uncertain. This study aimed to compare the vascular effects of achieving different treatment targets in PsA patients. Method This is a post hoc analysis of a 2 year treat-to-target study aimed at MDA. A total of 101 consecutive PsA patients without overt cardiovascular disease were recruited. High-resolution carotid ultrasound and arterial stiffness markers were assessed annually. Low disease activity (LDA) was defined as MDA, DAPSA ≤14 or PASDAS ≤3.2. Sustained disease control was defined as achieving these targets at each visit from month 12 until month 24. Results Ninety patients [52 male (57.8%), age 50 years (s.d. 11)] who completed 24 months of follow-up were included in this analysis. A total of 44%, 48% and 45% of patients achieved sustained DAPSA LDA (sDAPDA-LDA), sustained PASDAS LDA (sPASDAS-LDA) and sMDA, respectively. Patients who achieved sMDA had significantly less progression of carotid intima-media thickness than those who did not (P = 0.031). Using multivariate analysis, achieving sMDA and sPASDAS-LDA had a protective effect on plaque progression, less increase in total plaque area, reduced mean intima-media thickness and reduced augmentation index after adjusting for covariates. In contrast, no significant differences in the progression of vascular parameters were demonstrated between patients who did or did not achieve sDAPSA-LDA. Conclusion Achieving sMDA/sDASPAS-LDA, but not sDAPSA-LDA, was associated with a protective effect in subclinical atherosclerosis and arterial stiffness progression. A multidimensional domain of disease control might be better in minimizing cardiovascular risk in PsA.


2013 ◽  
Vol 14 (9) ◽  
pp. 622-628 ◽  
Author(s):  
Moemen Mohammed ◽  
Concetta Zito ◽  
Maurizio Cusmà-Piccione ◽  
Gianluca Di Bella ◽  
Francesco Antonini-Canterin ◽  
...  

Author(s):  
Emmanuelle Kesse-Guyot ◽  
Anne-Claire Vergnaud ◽  
Léopold Fezeu ◽  
Mahmoud Zureik ◽  
Jacques Blacher ◽  
...  

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