Marked Hyperthyroxinemia During Amiodarone Treatment Revealing Thyroid Hormone Resistance Syndrome

Thyroid ◽  
2008 ◽  
Vol 18 (9) ◽  
pp. 1019-1020 ◽  
Author(s):  
Bernard Goichot ◽  
Frédérique Savagner ◽  
Rémy Sapin ◽  
Florina Luca ◽  
Jean-Louis Schlienger
Keyword(s):  
Thyroid Hormone ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Amiodarone Treatment ◽  
Thyroid Hormone Resistance Syndrome

Thyroid hormone resistance syndrome – own experiences

2017 ◽  
Vol 23 (4) ◽  
pp. 209-214
Author(s):  
Tomasz Jackowski ◽  
◽  
Elżbieta Petriczko ◽  
Anita Horodnicka-Józwa ◽  
Mieczysław Walczak ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Thyroid Hormone Resistance Syndrome

scholarly journals Thyroid hormone resistance syndrome in a 12-year-old girl: clinical case description

2021 ◽  
Vol 10 (4) ◽  
pp. 105-107
Author(s):  
D.S. Romaykina ◽  
◽  
A.A. Matveeva ◽  
G.F. Okminyan ◽  
E.V. Kiseleva ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Clinical Case ◽  
Hormone Resistance ◽  
Case Description ◽  
Thyroid Hormone Resistance ◽  
Thyroid Hormone Resistance Syndrome

scholarly journals Differential diagnosis between autoimmune thyrotoxicosis and thyroid hormone resistance syndrome: clinical case report

2019 ◽  
Vol 65 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Natalya V. Mazurina ◽  
Ekaterina A. Troshina ◽  
Olga S. Chukhacheva
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Laboratory Tests ◽  
Direct Sequencing ◽  
Elevated Serum ◽  
Tissue Response ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Inappropriate Tsh Secretion ◽  
Thyroid Hormone Resistance Syndrome

We report a case of 50-year-old woman with thyroid hormone resistance syndrome. For 20 years this patient have been treated for autoimmune thyrotoxicosis: she underwent thyroid surgery and then was on thyroid-blocking therapy. Repeated laboratory tests demonstrated elevated serum thyroid hormones concentrations and elevated TSH concentration. Inappropriate TSH secretion became the reason for conducting further investigations. In those cases, the diagnostic approach is complicated and cases may be referred as a syndrome of thyroid hormones resistance or as a pituitary mass. Results of magnetic resonance imaging as well as results of octreotide test did not confirm TSH-producing pituitary adenoma. Lack of consistent thyrotoxicosis symptoms and normal level of biochemical markers that reflect peripheral tissue response to excessive thyroid hormones action were regarded as an evidence for thyroid hormones resistance syndrome. In cases of thyroid hormone resistance syndrome, there is no reduction in thyroid hormones after octreotide administration and we could observe it in our patient. Thereby clinical data and laboratory tests supported the diagnosis of thyroid hormone resistance syndrome. To establish definitive diagnosis and to verify genetic cause of the disease we performed direct sequencing of the THRB gene exons 910.

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