Thyroid-Stimulating Antibody is Related to Graves' Ophthalmopathy, But Thyrotropin-Binding Inhibitor Immunoglobulin is Related to Hyperthyroidism in Patients with Graves' Disease

Thyroid ◽  
2000 ◽  
Vol 10 (9) ◽  
pp. 809-813 ◽  
Author(s):  
Jaeduk Yoshimura Noh ◽  
Noboru Hamada ◽  
Yoichi Inoue ◽  
Yoshifumi Abe ◽  
Koichi Ito ◽  
...  
Keyword(s):  
Graves Disease ◽  
Thyroid Stimulating Antibody ◽  
Graves Ophthalmopathy

Correlation of orbital muscle changes evaluated by magnetic resonance imaging and thyroid-stimulating antibody in patients with Graves' ophthalmopathy

1993 ◽  
Vol 129 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Mitsushige Nishikawa ◽  
Masayoshi Yoshimura ◽  
Nagaoki Toyoda ◽  
Hiroya Masaki ◽  
Toshinaga Yonemoto ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Antithyroid Drugs ◽  
Graves Disease ◽  
Resonance Imaging ◽  
Thyroid Stimulating Antibody ◽  
Graves Ophthalmopathy ◽  
Growth Activity ◽  
Muscle Changes ◽  
Rat Thyroid

To evaluate the relationship between eye changes and autoantibody to the thyrotropin receptor in patients with Graves' disease, we evaluated the eye changes using magnetic resonance imaging and the results were correlated with thyroid-stimulating antibody, thyrotropin binding inhibitor immunoglobulin and thyroid growth activity. Subjects were 15 patients with Graves' disease who had Graves' ophthalmopathy, including exophthalmos and other signs and symptoms, and nine patients without ophthalmopathy; all were maintained in a euthyroid state by antithyroid drugs. The thyrotropin-binding inhibitor imunoglobulin was measured by a kit, and thyroid-stimulating antibody and thyroid growth activity were evaluated by cyclic adenosine 3′,5′-monophosphate production and [3H]thymidine incorporation, respectively, by cultured functional rat thyroid lined cells. The sum of the swelling ratios (muscle thickness to the diameter of the optic nerve) of the four extraocular muscles correlated well with the degree of exophthalmos. The thyrotropin-binding inhibitor immunoglobulin was positive in nine out of 15 patients with ophthalmopathy; however, no correlation was observed between the activity and exophthalmos or muscle swelling. No significant correlation was observed between muscle changes and thyroid growth activity either. On the other hand, thyroid-stimulating antibody (642±91%) in Graves' patients with ophthalmopathy was significantly (p<0.02) higher than that (315±84%) in patients without ophthalmopathy. Moreover, the level of the stimulating activity in Graves' patients with ophthalmopathy showed a significant (p < 0.02) positive correlation with the sum of the swelling ratios of the individual eight eye muscles. These results suggest that thyroid-stimulating antibody has a close relation to Graves' ophthalmopathy.

scholarly journals Predictive Factors of Development of Graves’ Ophthalmopathy for Patients with Juvenile Graves’ Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Dalia Jarusaitiene ◽  
Rasa Verkauskiene ◽  
Vytautas Jasinskas ◽  
Jurate Jankauskiene
Keyword(s):  
Predictive Factors ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Graves Disease ◽  
Cross Sectional ◽  
Ocular Manifestations ◽  
Graves Ophthalmopathy ◽  
Graves Orbitopathy ◽  
Low Incidence ◽  
Major Factors

Background. Due to low incidence of Graves’ ophthalmopathy (GO) among children, the manifestation is poorly analyzed, posing a risk to late identification of insidious disease.Purposes. To identify predictive factors that may influence the development of GO in pediatric and young patients with Graves’ disease (GD).Methods. A cross-sectional study of patients newly diagnosed with pediatric or juvenile GD during 2002–2012 was conducted at the Hospital of Lithuanian University of Health Sciences. Ocular evaluation was based on European Group on Graves’ Orbitopathy survey. The ocular manifestations were analyzed in relation to demographic, environmental, and clinical factors.Results. In total, 130 patients with juvenile GD were included; 29.2% had GO. Median age at GD onset was 17 yrs (IQR 4–29). Main symptoms of GO were eyelids retraction (73.7%), proptosis (65.8%), injection of conjunctiva (42.1%), and eyeball motility disturbance (21.1%). Major significant and independent risk factors for GO development were high initial concentration of FT4 (OR = 5.963), TTHAb (OR = 6.358), stress (OR = 6.030), and smoking (OR = 7.098).Conclusion. The major factors that could influence GO development were smoking, stress, and increased levels of initial TRAb, FT4. Slight proptosis, retraction of eyelids, and conjunctive injection were found as predominant ophthalmological symptoms in juvenile GO.

VALUE OF THYROID-STIMULATING-ANTIBODY DETERMINATIONS IN PREDICTING SHORT-TERM THYROTOXIC RELAPSE IN GRAVES' DISEASE

The Lancet ◽  
1977 ◽  
Vol 309 (8023) ◽  
pp. 1181-1182 ◽  
Author(s):  
T.F. Davies ◽  
D.C. Evered ◽  
B.Rees Smith ◽  
P.P.B. Yeo ◽  
F. Clark ◽  
...  
Keyword(s):  
Graves Disease ◽  
Short Term ◽  
Thyroid Stimulating Antibody

scholarly journals IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Qiuming Yao ◽  
Xiaofei An ◽  
Jing Zhang ◽  
Kaida Mu ◽  
Ling Li ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Susceptibility Gene ◽  
Thyroid Diseases ◽  
Minor Allele ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Graves Ophthalmopathy ◽  
Significant Difference

The objective of this study was to investigate whether IRF7 polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of IRF7, namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves’ disease, 297 with Hashimoto’s thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: P=0.017, OR=1.968; allele G: P=0.018, OR=1.946; rs1061502: AG genotype: P=0.029, OR=1.866; allele G: P=0.031, OR=1.847). Subgroup analysis also showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in Graves’ disease patients were both higher than those of the controls (rs1131665: AG genotype: P=0.015, OR=2.074; allele G: P=0.016, OR=2.048; rs1061502: AG genotype: P=0.034, OR=1.919; allele G: P=0.035, OR=1.898). Furthermore, the allele G frequency of rs1061501 was associated with Graves’ ophthalmopathy (P=0.035, OR=1.396). No significant difference in IRF7 polymorphisms was found between Hashimoto’s thyroiditis patients and controls. Our study has revealed for the first time that IRF7 is a susceptibility gene for AITD, especially for Graves’ disease and Graves’ ophthalmopathy.

scholarly journals Graves' ophthalmopathy: a preventable disease?

2002 ◽  
pp. 457-461 ◽  
Author(s):  
L Bartalena ◽  
C Marcocci ◽  
A Pinchera
Keyword(s):  
Environmental Factors ◽  
Graves Disease ◽  
Ocular Involvement ◽  
Preventable Disease ◽  
Graves Ophthalmopathy ◽  
External Variables ◽  
Risk Of Progression

Most patients with Graves' disease have some degree of ocular involvement, but only 3-5% of them develop severe ophthalmopathy (1). The reasons why only such a minority of patients with Graves' disease have severe expression of the ophthalmopathy remain to be elucidated. One possible explanation is that non-severe ophthalmopathy and severe ophthalmopathy are two different disorders with different genetic backgrounds; alternatively, they might be part of a spectrum of different conditions ranging from absent ocular involvement to most severe ophthalmopathy. In this case, external variables (i.e. environmental factors) must contribute to the nature of the expression of the disease. How important are they? How far can our intervention on environmental factors go towards reducing the risk of progression of the ophthalmopathy? In other words, to which extent, if any, is Graves' ophthalmopathy preventable? The aim of this mini-review is to address the above issues.

scholarly journals Influence of the TSH Receptor Gene on Susceptibility to Graves' Disease and Graves' Ophthalmopathy

Thyroid ◽  
2008 ◽  
Vol 18 (11) ◽  
pp. 1201-1206 ◽  
Author(s):  
Xiaoming Yin ◽  
Rauf Latif ◽  
Rebecca Bahn ◽  
Yaron Tomer ◽  
Terry F. Davies
Keyword(s):  
Receptor Gene ◽  
Tsh Receptor ◽  
Graves Disease ◽  
Graves Ophthalmopathy

scholarly journals Orbital lymphoma associated with Graves’ disease: A case report

2014 ◽  
Vol 71 (5) ◽  
pp. 510-514 ◽  
Author(s):  
Zoran Hajdukovic ◽  
Snezana Kuzmic-Jankovic ◽  
Tamara Kljakovic-Avramovic ◽  
Leposava Sekulovic ◽  
Ljiljana Tukic
Keyword(s):  
Case Report ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Marginal Zone ◽  
Radiation Treatment ◽  
Graves Disease ◽  
Decompression Surgery ◽  
Non Hodgkin Lymphoma ◽  
Graves Ophthalmopathy ◽  
Orbital Lymphoma

Introduction. The presence of bilateral exophthalmos and palpebral, periorbital edema associated with hyperthyroidism is most often considered as an initial sign of Graves? ophthalmopathy. However, in up to 20% of cases, Graves? ophthalmopathy might precede the occurrence of hyperthyroidism, which is very important to be considered in the differential diagnosis, especially if it is stated as unilateral. Among other less common causes of non-thyroid-related orbitopathy, orbital lymphoma represents rare conditions. We presented of a patient with Graves? disease, initially manifested as bilateral orbitopathy and progressive unilateral exophthalmos caused by the marginal zone B-cell non-Hodgkin lymphoma of the orbit. Case report. A 64-yearold man with the 3-year history of bilateral Graves? orbitopathy and hyperthyroidism underwent the left orbital decompression surgery due to the predominantly left, unilateral worsening of exophthalmos resistant to the previously applied glucocorticoid therapy. A year after the surgical treatment, a substantial exophthalmos of the left eye was again observed, signifying that other non-thyroid pathology could be involved. Orbital ultrasound was suggestive of primary orbital lymphoma, what was confirmed by orbital CT scan and the biopsy of the tumor tissue. Detailed examinations indicated that the marginal zone B-cell non-Hodgkin lymphoma extended to IV - B-b CS, IPI 3 (bone marrow infiltration: m+ orbit+). Upon the completion of the polychemiotherapy and the radiation treatment, a complete remission of the disease was achieved. Conclusion. Even when elements clearly indicate the presence of thyroid-related ophthalmopathy, disease deteriorating should raise a suspicion and always lead to imaging procedures to exclude malignancy.

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