Developmental and Hormonal Regulation of Thermosensitive Neuron Potential Activity in Rat Brain

Thyroid ◽  
1999 ◽  
Vol 9 (8) ◽  
pp. 837-843 ◽  
Author(s):  
SERGEI BELUGIN ◽  
KOZO AKINO ◽  
NOBORU TAKAMURA ◽  
MARIKO MINE ◽  
DMITRY ROMANOVSKY ◽  
...  
Keyword(s):  
Rat Brain ◽  
Hormonal Regulation ◽  
Thermosensitive Neuron ◽  
Potential Activity

Imidazo[1,2-b]pyridazines. IV. Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxy(Substituted Phenoxy and Naphthyloxy)-2-phenylimidazo[1,2-b]pyridazines

1988 ◽  
Vol 41 (11) ◽  
pp. 1735 ◽  
Author(s):  
GB Barlin ◽  
LP Davies ◽  
MML Ngu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Peripheral Nervous System ◽  
Pharmacological Activity ◽  
Plasma Membranes ◽  
Active Compounds ◽  
Ic50 Values ◽  
Potential Activity ◽  
Made In

Syntheses are reported for some 3-methoxy-6-phenoxy(substituted phenoxy and naphthyloxy )-2-phenylimidazo[1,2-b] pyridazines; they were made in order to study their possible pharmacological activity in the mammalian central and peripheral nervous system. In initial biological screens to detect compounds with potential activity at receptors for the benzodiazepine class of drugs, the most active compounds were 3-methoxy-6-(2′-methylthiophenoxy)- and 6-(2′-dimethylaminophenoxy )-3-methoxy-2-phenylimidazo[1,2-b] pyridazine. Their respective IC50 values for displacement of 3H-diazepam (IC50 for unlabelled diazepam, 4.2 nM ) from rat brain plasma membranes (measured in the presence of 100 μM GABA) were 112 and 149 nM.

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