Polyamine Synthesis and Transport Inhibition in a Human Anaplastic Thyroid Carcinoma Cell Line In Vitro and as Xenograft Tumors

Thyroid ◽  
1999 ◽  
Vol 9 (8) ◽  
pp. 805-814 ◽  
Author(s):  
MUSTAFA YATIN ◽  
GOPALAKRISHNAN M. VENKATARAMAN ◽  
REGINA MARCINEK ◽  
KENNETH B. AIN
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Polyamine Synthesis ◽  
Thyroid Carcinoma Cell Line ◽  
Transport Inhibition ◽  
Thyroid Carcinoma Cell

Cell death induced by 131I in a differentiated thyroid carcinoma cell line in vitro: Necrosis or apoptosis?

2006 ◽  
Vol 27 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Kathrin Marx ◽  
Detlef Moka ◽  
Klaus Schomäcker ◽  
Thomas Fischer ◽  
Beate Gabruk-Szostak ◽  
...  
Keyword(s):  
Cell Death ◽  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Differentiated Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

scholarly journals Therapeutic Usefulness of Wild-Typep53Gene Introduction in ap53-Null Anaplastic Thyroid Carcinoma Cell Line

1998 ◽  
Vol 83 (10) ◽  
pp. 3668-3672 ◽  
Author(s):  
Masaharu Narimatsu ◽  
Yuji Nagayama ◽  
Kozo Akino ◽  
Masako Yasuda ◽  
Toshinori Yamamoto ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

In Vitro and In Vivo Properties of a Human Anaplastic Thyroid Carcinoma Cell Line Transfected with the Sodium Iodide Symporter Gene

Thyroid ◽  
2004 ◽  
Vol 14 (11) ◽  
pp. 889-895 ◽  
Author(s):  
Yong Jin Lee ◽  
June-Key Chung ◽  
Jae Hoon Shin ◽  
Joo Hyun Kang ◽  
Jae Min Jeong ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Sodium Iodide ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Sodium Iodide Symporter ◽  
Thyroid Carcinoma Cell

scholarly journals Clodronate alleviates cachexia and prolongs survival in nude mice xenografted with an anaplastic thyroid carcinoma cell line

2006 ◽  
Vol 190 (2) ◽  
pp. 415-423 ◽  
Author(s):  
Cheng-Hsu Wang ◽  
Yung-Chi Shen ◽  
Jia-Juan Hsieh ◽  
Kun-Yun Yeh ◽  
John Wen-Cheng Chang
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Nude Mice ◽  
Cancer Cachexia ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Dependent Manner ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

Cancer cachexia is one of the most common manifestations of advanced malignant disease and is frequently associated with decreased survival. Previously, we reported the establishment of a new anaplastic thyroid carcinoma cell line, Thena, and its mouse xenograft, Thena-Nu, which induced cachexia in athymic nude mice. Subsequent studies showed that the addition of clodronate to Thena-Nu cultures reduced cell proliferation as well as cytokine production in a dose- and time-dependent manner. Weekly administration of clodronate induced tumor cytostasis, attenuation of cachexia, as well as prolongation of survival in Thena-Nu-bearing mice. Reduced serum interleukin 6, tumor necrosis factor-α, and granulocyte colony stimulating factor levels were detected, whereas, serum leukemia inhibitory factor levels were not reduced. Liver necrosis, observed in tumor-bearing mice, was also improved following clodronate treatment. Discontinuation of clodronate treatment, however, resulted in progressive tumor growth and weight loss. Our results demonstrated that clodronate could exert therapeutic efficacy on amelioration of cancer cachexia in the hosts. Nevertheless, this study also points out that a longer period of treatment is required to maintain these effects.

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