scholarly journals Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model

2017 ◽  
Vol 23 (11) ◽  
pp. 745-753 ◽  
Author(s):  
Christian G. Pfeifer ◽  
Matthew B. Fisher ◽  
Vishal Saxena ◽  
Minwook Kim ◽  
Elizabeth A. Henning ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Defect Model ◽  
Age Dependent ◽  
And Cartilage

The Effect of Single vs Serial Platelet-Rich Plasma Injections in Osteochondral Lesions Treated With Microfracture: An In Vivo Rabbit Model

2021 ◽  
pp. 036354652110525
Author(s):  
Youichi Yasui ◽  
John F. Dankert ◽  
Ichiro Tonogai ◽  
Nathaniel P. Mercer ◽  
Margaret B. Goodale ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Inflammatory Cytokine ◽  
Platelet Rich Plasma ◽  
Cytokine Expression ◽  
Osteochondral Lesions ◽  
Micro Ct ◽  
Cartilaginous Tissue ◽  
Expression Levels

Background: Biological adjuvants are used after a musculoskeletal injury to improve healing, decrease inflammation, and restore joint homeostasis. Work on 1 such adjuvant, platelet-rich plasma (PRP), has suggested a positive effect when introduced during cartilage repair. However, it remains unknown whether healing osteochondral injuries benefit from serial PRP injections. Purpose: To evaluate the effects of serial PRP injections versus a single PRP injection on reparative cartilaginous tissue, subchondral bone remodeling, and the expression of inflammatory cytokines in joint synovium. Study Design: Controlled laboratory study. Methods: A total of 48 New Zealand White rabbits were randomly assigned to receive 1 (1P), 2 (2P), or 3 (3P) PRP injections. Cylindrical full-thickness cartilage defects (2.9 × 2.9 mm) with microdrillings (0.6-mm diameter) were created on the medial condyles of both knees. PRP was injected into the right knee after closure (groups 1P, 2P, and 3P), at 2 weeks after surgery (groups 2P and 3P), and at 4 weeks after surgery (group 3P). The left knees did not receive any PRP injections. A total of 6 rabbits in each group were euthanized at 3, 6, and 12 weeks postoperatively. Cartilage repair tissue was assessed using the Goebel macroscopic and modified International Cartilage Regeneration & Joint Preservation Society (ICRS) histological scoring systems. Subchondral bone remodeling was evaluated by micro–computed tomography analysis (micro-CT). Inflammatory cytokine levels were assessed by quantitative polymerase chain reaction. Results: No significant differences were found for the mean macroscopic score between the PRP groups at 12 weeks (control, 6.1 ± 3.3; group 1P, 3.4 ± 2.7; group 2P, 4.2 ± 2.9; group 3P, 0.7 ± 1.5). All PRP groups had a significantly higher mean modified ICRS histological score compared with the control group, but no significant difference was found among the PRP groups. No significant differences were seen in outcomes for the tested micro-CT parameters or cytokine expression levels. Conclusion: Serial PRP injections conferred no apparent advantage over single injections according to evaluations of the macroscopic and histological appearance of the cartilaginous tissue, subchondral bone healing, and inflammatory cytokine expression levels in the synovium. Clinical Relevance: The use of PRP as a biological adjuvant to bone marrow stimulation for osteochondral lesions has the potential to enhance the quality of regenerative cartilaginous tissue. We recommend only a single PRP injection if the use of PRP is indicated by the operating surgeon as an adjuvant therapy for osteochondral lesions.

scholarly journals 299 DEPTH-WISE ANALYSIS OF SUBCHONDRAL BONE PROPERTIES: IMPLICATIONS IN OSTEOARTHRITIS AND CARTILAGE REPAIR

2010 ◽  
Vol 18 ◽  
pp. S134 ◽  
Author(s):  
M. Hurtig ◽  
S. Allendorf ◽  
A. Bell ◽  
M. Lowerison ◽  
C. Hoemann
Keyword(s):  
Cartilage Repair ◽  
Subchondral Bone ◽  
Bone Properties ◽  
And Cartilage

Positive Effect of Alendronate on Subchondral Bone Healing and Subsequent Cartilage Repair in a Rabbit Osteochondral Defect Model

2009 ◽  
Vol 37 (1_suppl) ◽  
pp. 139-147 ◽  
Author(s):  
Kohei Nishitani ◽  
Takaaki Shirai ◽  
Masahiko Kobayashi ◽  
Hiroshi Kuroki ◽  
Yoshiaki Azuma ◽  
...  
Keyword(s):  
Cartilage Repair ◽  
Subchondral Bone ◽  
Bone Healing ◽  
Osteochondral Defect ◽  
Defect Model ◽  
Positive Effect

Subchondral bone and cartilage repair with bioactive glasses, hydroxyapatite, and hydroxyapatite-glass composite

1996 ◽  
Vol 32 (4) ◽  
pp. 543-551 ◽  
Author(s):  
Erkki Suominen ◽  
Allan J. Aho ◽  
Erik Vedel ◽  
Ilkka Kangasniemi ◽  
E. Uusipaikka ◽  
...  
Keyword(s):  
Cartilage Repair ◽  
Subchondral Bone ◽  
Glass Composite ◽  
Bioactive Glasses ◽  
And Cartilage

scholarly journals Cartilage Repair and Subchondral Bone Remodeling in Response to Focal Lesions in a Mini-Pig Model: Implications for Tissue Engineering

2015 ◽  
Vol 21 (3-4) ◽  
pp. 850-860 ◽  
Author(s):  
Matthew B. Fisher ◽  
Nicole S. Belkin ◽  
Andrew H. Milby ◽  
Elizabeth A. Henning ◽  
Marc Bostrom ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Remodeling ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Pig Model ◽  
Focal Lesions

scholarly journals Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation

2021 ◽  
Vol 12 ◽  
Author(s):  
Chenyang Zhuang ◽  
Zixiang Wang ◽  
Weisin Chen ◽  
Hanquan Wang ◽  
Bo Tian ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Subchondral Bone ◽  
Cruciate Ligament ◽  
Osteoclast Differentiation ◽  
Nuclear Factor Κb ◽  
Osteoclast Formation ◽  
Joint Disease ◽  
Chondrocyte Apoptosis ◽  
And Cartilage

Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management. Jintiange (Jtg) capsules are a traditional Chinese medicine produced from multiple organic components of various animal bones and routinely used to treat osteoporosis in China. However, the effect of Jtg on subchondral bone and cartilage degeneration in OA remains unknown. The purpose of the present study was to investigate the biomolecular role and underlying mechanisms of Jtg in OA progression. Herein, we found that Jtg inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation and it functions through the NF-κB signaling pathway. Jtg also inhibited chondrocyte apoptosis via reducing the reactive oxygen species concentration in these cells. Moreover, in vivo evaluation revealed that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in anterior cruciate ligament transection (ACLT) mouse models. Taken together, our data demonstrate that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage, supporting its potential therapeutic value for treating OA.

scholarly journals Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect model

2013 ◽  
Vol 34 (6) ◽  
pp. 281-288 ◽  
Author(s):  
Sakura UTO ◽  
Satoru NISHIZAWA ◽  
Yutaka TAKASAWA ◽  
Yukiyo ASAWA ◽  
Yuko FUJIHARA ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Cartilage Repair ◽  
Pluripotent Stem Cells ◽  
Defect Model ◽  
Induced Pluripotent ◽  
And Cartilage

Correlation between the subchondral bone marrow lesions and cartilage repair tissue after matrix-associated autologous chondrocyte implantation in the knee: a cross-sectional study

2020 ◽  
pp. 028418512096995
Author(s):  
Jialing Lyu ◽  
Yindi Zhang ◽  
Weimin Zhu ◽  
Dingfu Li ◽  
Weiqiang Lin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Relaxation Time ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Autologous Chondrocyte Implantation ◽  
Repair Tissue ◽  
Bone Marrow Lesions ◽  
Chondrocyte Implantation ◽  
And Cartilage ◽  
Autologous Chondrocyte

Background The contribution of the subchondral bone in the development and progression of osteoarthritis (OA) has long been recognized, but its role in cartilage repair procedures has only recently attracted more attention. Purpose To explore the correlation between the cartilage repair tissue (RT) and the subchondral bone marrow lesions (BMLs) after matrix-associated autologous chondrocyte implantation (MACI) in the knee joint. Material and Methods A total of 30 patients who underwent MACI in the knee from January 2015 to June 2018 and follow-up magnetic resonance imaging (MRI) scan were recruited in this study. The MRI results of cartilage RT were evaluated using T2* relaxation time. Subchondral BMLs were also qualitatively evaluated by use of the two-dimensional proton density-weighted fat-suppressed (2D-PD-FS) and three-dimensional dual-echo steady-state (3D-DESS) sequences. Results The univariate analysis displayed a significant negative correlation between subchondral BMLs and cartilage RT ( P < 0.01). In the minimally adjusted model (only age, sex, and body mass index [BMI] adjusted), the results did not show obvious changes (β = –6.54, 95% confidence interval [CI] = –10.99 to –2.09; P = 0.008). After adjustment for the full models (age, sex, BMI, defect size, combined injury, and preoperative duration of symptoms adjusted), the connection was also detected (β = –6.66, 95% CI –11.82 to –1.50; P = 0.019). Conclusion After MACI, the subchondral BMLs are significantly correlated with cartilage RT-T2* relaxation time. The role of subchondral bone in cartilage repair procedures should not be underestimated.

Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery

2018 ◽  
Vol 18 (3) ◽  
pp. 154-170 ◽  
Author(s):  
Sofia Bougioukli ◽  
Christopher H. Evans ◽  
Ram K. Alluri ◽  
Steven C. Ghivizzani ◽  
Jay R. Lieberman
Keyword(s):  
Gene Therapy ◽  
Cartilage Repair ◽  
Orthopaedic Surgery ◽  
And Cartilage
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