scholarly journals Large Animal Models of Meniscus Repair and Regeneration: A Systematic Review of the State of the Field

2017 ◽  
Vol 23 (11) ◽  
pp. 661-672 ◽  
Author(s):  
Sonia Bansal ◽  
Niobra M. Keah ◽  
Alexander L. Neuwirth ◽  
Olivia O'Reilly ◽  
Feini Qu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Meniscus Repair ◽  
The State ◽  
Large Animal ◽  
Large Animal Models ◽  
State Of The Field

scholarly journals A systematic review of large animal models of combined traumatic brain injury and hemorrhagic shock

2019 ◽  
Vol 104 ◽  
pp. 160-177 ◽  
Author(s):  
Andrew R. Mayer ◽  
Andrew B. Dodd ◽  
Meghan S. Vermillion ◽  
David D. Stephenson ◽  
Irshad H. Chaudry ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Animal Models ◽  
Hemorrhagic Shock ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease

2011 ◽  
Vol 91 (4) ◽  
pp. 649-658 ◽  
Author(s):  
T. I. G. van der Spoel ◽  
S. J. Jansen of Lorkeers ◽  
P. Agostoni ◽  
E. van Belle ◽  
M. Gyongyosi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Heart Disease ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

2019 ◽  
Vol 39 (3) ◽  
pp. 375-394 ◽  
Author(s):  
Andrea M Herrmann ◽  
Stephan Meckel ◽  
Matthew J Gounis ◽  
Leona Kringe ◽  
Edith Motschall ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Animal Models ◽  
Translational Research ◽  
Arteriovenous Malformations ◽  
Vascular Malformations ◽  
Large Animal ◽  
Large Animal Models ◽  
Large Animals ◽  
Study Designs

Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.

Large animal models for long-segment tracheal reconstruction: a systematic review

2018 ◽  
Vol 231 ◽  
pp. 140-153 ◽  
Author(s):  
Cindy Siaw-Lin Goh ◽  
Janna-Vale Joethy ◽  
Bien-Keem Tan ◽  
Manzhi Wong
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Large Animal ◽  
Tracheal Reconstruction ◽  
Large Animal Models

scholarly journals Quality and validity of large animal experiments in stroke: A systematic review

2020 ◽  
Vol 40 (11) ◽  
pp. 2152-2164 ◽  
Author(s):  
Leona Kringe ◽  
Emily S Sena ◽  
Edith Motschall ◽  
Zsanett Bahor ◽  
Qianying Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Small Animal ◽  
Research Quality ◽  
Quality Analysis ◽  
Large Animal ◽  
Study Quality ◽  
Large Animal Models ◽  
Stroke Research ◽  
Stroke Models

An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research. However, little is known about the methodological rigor and quality in large animal stroke models, which are becoming more frequently used in the field. Based on research in two databases, this systematic review surveys and analyses the methodological quality in large animal stroke research. Quality analysis was based on the Stroke Therapy Academic Industry Roundtable and the Animals in Research: Reporting In Vivo Experiments guidelines. Our analysis revealed that large animal models are utilized with similar shortcomings as small animal models. Moreover, translational benefits of large animal models may be limited due to lacking implementation of important quality criteria such as randomization, allocation concealment, and blinded assessment of outcome. On the other hand, an increase of study quality over time and a positive correlation between study quality and journal impact factor were identified. Based on the obtained findings, we derive recommendations for optimal study planning, conducting, and data analysis/reporting when using large animal stroke models to fully benefit from the translational advantages offered by these models.

scholarly journals Large Animal Models for Investigating Cell Therapies of Stress Urinary Incontinence

2021 ◽  
Vol 22 (11) ◽  
pp. 6092
Author(s):  
Bastian Amend ◽  
Niklas Harland ◽  
Jasmin Knoll ◽  
Arnulf Stenzl ◽  
Wilhelm K. Aicher
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Animal Models ◽  
Clinical Situation ◽  
Surgical Instruments ◽  
Health Concern ◽  
Large Animal ◽  
Knock Out ◽  
Cell Therapies ◽  
Large Animal Models

Stress urinary incontinence (SUI) is a significant health concern for patients affected, impacting their quality of life severely. To investigate mechanisms contributing to SUI different animal models were developed. Incontinence was induced under defined conditions to explore the pathomechanisms involved, spontaneous recovery, or efficacy of therapies over time. The animal models were coined to mimic known SUI risk factors such as childbirth or surgical injury. However, animal models neither reflect the human situation completely nor the multiple mechanisms that ultimately contribute to the pathogenesis of SUI. In the past, most SUI animal studies took advantage of rodents or rabbits. Recent models present for instance transgenic rats developing severe obesity, to investigate metabolic interrelations between the disorder and incontinence. Using recombinant gene technologies, such as transgenic, gene knock-out or CRISPR-Cas animals may narrow the gap between the model and the clinical situation of patients. However, to investigate surgical regimens or cell therapies to improve or even cure SUI, large animal models such as pig, goat, dog and others provide several advantages. Among them, standard surgical instruments can be employed for minimally invasive transurethral diagnoses and therapies. We, therefore, focus in this review on large animal models of SUI.

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