Development of a Large Animal Long-Term Intervertebral Disc Organ Culture Model That Includes the Bony Vertebrae for Ex Vivo Studies

2016 ◽  
Vol 22 (7) ◽  
pp. 636-643 ◽  
Author(s):  
Michael Grant ◽  
Laura M. Epure ◽  
Omar Salem ◽  
Nizar AlGarni ◽  
Ovidiu Ciobanu ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Organ Culture ◽  
Ex Vivo ◽  
Large Animal ◽  
Culture Model

scholarly journals Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model

2014 ◽  
Vol 14 (11) ◽  
pp. 2724-2732 ◽  
Author(s):  
Svenja Illien-Jünger ◽  
Young Lu ◽  
Devina Purmessur ◽  
Jillian E. Mayer ◽  
Benjamin A. Walter ◽  
...  
Keyword(s):  
Growth Factor ◽  
Intervertebral Disc ◽  
Organ Culture ◽  
Large Animal ◽  
Culture Model ◽  
Animal Organ ◽  
Growth Factor Treatment

Short Link N Stimulates Intervertebral Disc Repair in a Novel Long-Term Organ Culture Model that Includes the Bony Vertebrae

2016 ◽  
Vol 22 (21-22) ◽  
pp. 1252-1257 ◽  
Author(s):  
Nizar AlGarni ◽  
Michael P. Grant ◽  
Laura M. Epure ◽  
Omar Salem ◽  
Rakan Bokhari ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Organ Culture ◽  
Culture Model ◽  
Disc Repair ◽  
Intervertebral Disc Repair ◽  
Short Link

Establishment of a Novel Intervertebral Disc/Endplate Culture Model: Analysis of an Ex Vivo In Vitro Whole-Organ Rabbit Culture System

Spine ◽  
2006 ◽  
Vol 31 (25) ◽  
pp. 2918-2925 ◽  
Author(s):  
Daniel Haschtmann ◽  
Jivko V. Stoyanov ◽  
Ladina Ettinger ◽  
Lutz -P. Nolte ◽  
Stephen J. Ferguson
Keyword(s):  
Intervertebral Disc ◽  
Culture System ◽  
Ex Vivo ◽  
Model Analysis ◽  
Culture Model

Bench-Top Validation Tests for Tissue-Engineered Arteries

2000 ◽  
Author(s):  
Shawn Chin Quee ◽  
Hai-Chao Han ◽  
David N. Ku
Keyword(s):  
Organ Culture ◽  
Culture System ◽  
Comprehensive Evaluation ◽  
Ex Vivo ◽  
Vascular Grafts ◽  
Living System ◽  
Organ Culture System ◽  
Flow Pressure ◽  
Validation Tests

Abstract Standard tests are needed for evaluating and comparing the mechanical and biological functions of tissue engineered arteries and other vascular grafts. We propose an ex vivo organ culture system as a living system for testing tissue-engineered vascular grafts. This bench-top organ culture system mimics the physiological environment of arteries including the flow, pressure, and the axial stretch. Arterial mechanical properties and physiologic functions including compliance, burst pressure, and contractile functions can be assessed before an expensive long-term animal test is initiated. Test results of natural arteries indicate that organ culture is a valid model for comprehensive evaluation of tissue-engineered vascular grafts.

scholarly journals Effects of Asymmetric Dynamic Loading on Intervertebral Disc – towards a Scoliosis Mimicking Organ Culture Model

2016 ◽  
Vol 6 (1_suppl) ◽  
pp. s-0036-1582636-s-0036-1582636
Author(s):  
Zhen Li ◽  
Ying Zhang ◽  
Lukas Straumann ◽  
Patrick Lezuo ◽  
Marianna Peroglio ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Organ Culture ◽  
Dynamic Loading ◽  
Culture Model

Effects of Caffeine on Intervertebral Disc Cell Viability in a Whole Organ Culture Model

2017 ◽  
Vol 17 (10) ◽  
pp. S125-S126
Author(s):  
Benjamin T. Raines ◽  
James T. Stannard ◽  
Olivia E. Stricklin ◽  
Aaron M. Stoker ◽  
Theodore J. Choma ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Organ Culture ◽  
Cell Viability ◽  
Disc Cell ◽  
Culture Model

scholarly journals Organomatics and organometrics: Novel platforms for long-term whole-organ culture

TECHNOLOGY ◽  
2014 ◽  
Vol 02 (01) ◽  
pp. 13-22 ◽  
Author(s):  
Bote G. Bruinsma ◽  
Martin L. Yarmush ◽  
Korkut Uygun
Keyword(s):  
Organ Culture ◽  
Ex Vivo ◽  
Regulatory Control ◽  
Computational Algorithms ◽  
Machine Perfusion ◽  
Organ Function ◽  
Organ Models ◽  
Term Maintenance ◽  
Organ Replacement

Organ culture systems are instrumental as experimental whole-organ models of physiology and disease, as well as preservation modalities facilitating organ replacement therapies such as transplantation. Nevertheless, a coordinated system of machine perfusion components and integrated regulatory control has yet to be fully developed to achieve long-term maintenance of organ function ex vivo. Here we outline current strategies for organ culture, or organomatics, and how these systems can be regulated by means of computational algorithms, or organometrics, to achieve the organ culture platforms anticipated in modern-day biomedicine.

scholarly journals 178 AN ORGAN CULTURE MODEL TO STUDY BIOLOGICAL REPAIR OF THE DEGENERATE INTERVERTEBRAL DISC

2009 ◽  
Vol 17 ◽  
pp. S104-S105
Author(s):  
L.A. Haglund ◽  
J. Moir ◽  
B. Jim ◽  
P.J. Roughley ◽  
T. Steffen
Keyword(s):  
Intervertebral Disc ◽  
Organ Culture ◽  
Biological Repair ◽  
Culture Model
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