Thermoswitching Microgel Carriers Improve Neuronal Cell Growth and Cell Release for Cell Transplantation

2015 ◽  
Vol 21 (1) ◽  
pp. 65-76 ◽  
Author(s):  
Dennis Jgamadze ◽  
Li Liu ◽  
Steffen Vogler ◽  
Liang-Yin Chu ◽  
Sophie Pautot
Keyword(s):  
Cell Growth ◽  
Cell Transplantation ◽  
Neuronal Cell ◽  
Cell Release

scholarly journals Tackling Cell Transplantation Anoikis: An Injectable, Shape Memory Cryogel Microcarrier Platform Material for Stem Cell and Neuronal Cell Growth

Small ◽  
2015 ◽  
Vol 11 (38) ◽  
pp. 5047-5053 ◽  
Author(s):  
Ben Newland ◽  
Petra B. Welzel ◽  
Heike Newland ◽  
Claudia Renneberg ◽  
Petr Kolar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Growth ◽  
Shape Memory ◽  
Cell Transplantation ◽  
Neuronal Cell

scholarly journals Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xiangyang Xia ◽  
Quanwei Tao ◽  
Qunchao Ma ◽  
Huiqiang Chen ◽  
Jian’an Wang ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cell Growth ◽  
Cell Transplantation ◽  
Antitumor Agents ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Angiogenic Potential ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
The Relationship

Mesenchymal stromal cells (MSCs) are promising candidates for regenerative medicine because of their multipotency, immune-privilege, and paracrine properties including the potential to promote angiogenesis. Accumulating evidence suggests that the inherent properties of cytoprotection and tissue repair by native MSCs can be enhanced by various preconditioning stimuli implemented prior to cell transplantation. Growth hormone-releasing hormone (GHRH), a stimulator in extrahypothalamus systems including tumors, has attracted great attentions in recent years because GHRH and its agonists could promote angiogenesis in various tissues. GHRH and its agonists are proangiogenic in responsive tissues including tumors, and GHRH antagonists have been tested as antitumor agents through their ability to suppress angiogenesis and cell growth. GHRH-R is expressed by MSCs and evolving work from our laboratory indicates that treatment of MSCs with GHRH agonists prior to cell transplantation markedly enhanced the angiogenic potential and tissue reparative properties of MSCs through a STAT3 signaling pathway. In this review we summarized the possible effects of GHRH analogues on cell growth and development, as well as on the proangiogenic properties of MSCs. We also discussed the relationship between GHRH analogues and MSC-mediated angiogenesis. The analyses provide new insights into molecular pathways of MSCs-based therapies and their augmentation by GHRH analogues.

Effects of O2 and N2/H2 plasma treatments on the neuronal cell growth on single-walled carbon nanotube paper scaffolds

2011 ◽  
Vol 257 (20) ◽  
pp. 8535-8541 ◽  
Author(s):  
Ok Ja Yoon ◽  
Hyun Jung Lee ◽  
Yeong Mi Jang ◽  
Hyun Woo Kim ◽  
Won Bok Lee ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Cell Growth ◽  
Neuronal Cell ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Plasma Treatments

scholarly journals Neuronal cell growth on polymeric scaffolds studied by CARS microscopy

2012 ◽  
Author(s):  
Annika Enejder ◽  
Helen Fink ◽  
Hans-Georg Kuhn
Keyword(s):  
Cell Growth ◽  
Neuronal Cell ◽  
Polymeric Scaffolds ◽  
Cars Microscopy

scholarly journals Simple Synthetic Molecular Hydrogels from Self-Assembling Alkylgalactonamides as Scaffold for 3D Neuronal Cell Growth

2018 ◽  
Vol 10 (20) ◽  
pp. 17004-17017 ◽  
Author(s):  
Anaïs Chalard ◽  
Laurence Vaysse ◽  
Pierre Joseph ◽  
Laurent Malaquin ◽  
Sandrine Souleille ◽  
...  
Keyword(s):  
Cell Growth ◽  
Neuronal Cell ◽  
Self Assembling

scholarly journals Directing neuronal cell growth on implant material surfaces by microstructuring

2012 ◽  
Vol 100B (4) ◽  
pp. 940-947 ◽  
Author(s):  
Uta Reich ◽  
Elena Fadeeva ◽  
Athanasia Warnecke ◽  
Gerrit Paasche ◽  
Peter Müller ◽  
...  
Keyword(s):  
Cell Growth ◽  
Neuronal Cell ◽  
Material Surfaces ◽  
Implant Material

scholarly journals Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Qian Li ◽  
Yanjie Jia ◽  
John Zhang ◽  
Jun Yang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Transgenic Mice ◽  
Western Blot ◽  
Neuronal Differentiation ◽  
Cell Transplantation ◽  
Neuronal Cell ◽  
Marrow Mesenchymal Stem Cells ◽  
Differentiation Efficiency

Objective. Even though there is a therapeutic potential to treat Alzheimer’s disease (AD) with neural cell replenishment and replacement, immunological rejections of stem cell transplantation remain a challenging risk. Autologous stem cells from AD patients however may prove to be a promising candidate. Therefore, we studied the neuronal differentiation efficiency of bone marrow mesenchymal stem cells (MSCs) from APP695 transgenic mice, which share features of human AD.Method. Cultured MSCs from APP695 transgenic mice are used; neuronal differentiation was assessed by immunocytochemistry and Western blot. Correlation with Notch signaling was examined. Autophage flux was assessed by western blot analysis.Results. MSCs from APP695 mice have higher neuronal differentiation efficiency than MSCs from wild type mice (WT MSCs). The expression of Notch-1 signaling decreased during the differentiation process. However, autophagy flux, which is essential for neuronal cell survival and neuronal function, was impaired in the neuronally differentiated counterparts of APP695 MSCs (APP695 MSCs–n).Conclusion. These results suggested autologous MSCs of APP690 mice may not be a good candidate for cell transplantation.

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