scholarly journals Computed Tomography-Guided Tissue Engineering of Upper Airway Cartilage

2014 ◽  
Vol 20 (6) ◽  
pp. 506-513 ◽  
Author(s):  
Bryan N. Brown ◽  
Nicholas J. Siebenlist ◽  
Jonathan Cheetham ◽  
Norm G. Ducharme ◽  
Jeremy J. Rawlinson ◽  
...  
2021 ◽  
pp. 019459982110021
Author(s):  
Austin S. Lam ◽  
Michael D. Bindschadler ◽  
Kelly N. Evans ◽  
Seth D. Friedman ◽  
Jeffrey P. Otjen ◽  
...  

Thorough assessment of dynamic upper airway obstruction (UAO) in Robin sequence (RS) is critical, but traditional evaluation modalities have significant limitations. Four-dimensional computed tomography (4D-CT) is promising in that it enables objective and quantitative evaluation throughout all phases of respiration. However, there exist few protocols or analysis tools to assist in obtaining and interpreting the vast amounts of obtained data. A protocol and set of data analysis tools were developed to enable quantification and visualization of dynamic 4D-CT data. This methodology was applied to a sample case at 2 time points. In the patient with RS, overall increases in normalized airway caliber were observed from 5 weeks to 1 year. There was, however, continued dynamic obstruction at all airway levels, though objective measures of UAO did improve at the nasopharynx and oropharynx. Use of 4D-CT and novel analyses provide additional quantitative information to evaluate UAO in patients with RS.


2012 ◽  
Vol 82 (3) ◽  
pp. 458-463 ◽  
Author(s):  
Annelise Nazareth Cunha Ribeiro ◽  
João Batista de Paiva ◽  
José Rino-Neto ◽  
Edson Illipronti-Filho ◽  
Tarcila Trivino ◽  
...  

Biomaterials ◽  
2019 ◽  
Vol 188 ◽  
pp. 38-49 ◽  
Author(s):  
Deepak Bushan Raina ◽  
Irfan Qayoom ◽  
David Larsson ◽  
Ming Hao Zheng ◽  
Ashok Kumar ◽  
...  

Author(s):  
Desi Sandra Sari ◽  
Fourier Dzar Eljabbar Latief ◽  
Ferdiansyah ◽  
Ketut Sudiana ◽  
Fedik Abdul Rantam

The tissue engineering approach for periodontal tissue regeneration using a combination of stem cells and scaffold has been vastly developed. Mesenchymal Stem Cells (MSCs) seeded with Bovine Teeth Scaffold (BTSc) can repair alveolar bone damage in periodontitis cases. The alveolar bone regeneration process was analyzed by micro-computed tomography (µ-CT) to observe the structure of bone growth and to visualize the scaffold in 3-Dimensional (3D). The purpose of this study is to analyze alveolar bone regeneration by µ-CT following the combination of MSCs and bovine teeth scaffold (MSCs-BTSc) implantation in the Wistar rat periodontitis model. Methods. MSCs were cultured from adipose-derived mesenchymal stem cells of rats. BTSc was taken from bovine teeth and freeze-dried with a particle size of 150-355 µm. MSCs were seeded on BTSc for 24 hours and transplanted in a rat model of periodontitis. Thirty-five Wistar rats were made as periodontitis models with LPS induction from P. gingivalis injected to the buccal section of interproximal gingiva between the first and the second mandibular right-molar teeth for six weeks. There were seven groups (control group, BTSc group on day 7, BTSc group on day 14, BTSc group on day 28, MSCs-BTSc group on day 7, MSCs-BTSc group on day 14, MSCs-BTSc group on day 28). The mandibular alveolar bone was analyzed and visualized in 3D with µ-CT to observe any new bone growth. Statistical Analysis. Group data were subjected to the Kruskal Wallis test followed by the Mann-Whitney (p <0.05). The µ-CT qualitative analysis shows a fibrous structure, which indicates the existence of new bone regeneration. Quantitative analysis of the periodontitis model showed a significant difference between the control model and the model with the alveolar bone resorption (p <0.05). The bone volume and density measurements revealed that the MSCs-BTSc group on day 28 formed new bone compared to other groups (p <0.05). Administration of MSCs-BTSc combination has the potential to form new alveolar bone.


2008 ◽  
Vol 14 (7) ◽  
pp. 1195-1202 ◽  
Author(s):  
Jeffrey J. Ballyns ◽  
Jason P. Gleghorn ◽  
Vicki Niebrzydowski ◽  
Jeremy J. Rawlinson ◽  
Hollis G. Potter ◽  
...  

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