Mass Production of Nanofibrous Extracellular Matrix with Controlled 3D Morphology for Large-Scale Soft Tissue Regeneration

2013 ◽  
Vol 19 (6) ◽  
pp. 458-472 ◽  
Author(s):  
Mohammad A. Alamein ◽  
Sebastien Stephens ◽  
Qin Liu ◽  
Stuart Skabo ◽  
Patrick H. Warnke
Keyword(s):  
Extracellular Matrix ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Mass Production ◽  
Large Scale ◽  
Soft Tissue Regeneration ◽  
3D Morphology

scholarly journals Extracellular matrix‐based scaffolding technologies for periodontal and peri‐implant soft tissue regeneration

2019 ◽  
Vol 91 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Lorenzo Tavelli ◽  
Michael K. McGuire ◽  
Giovanni Zucchelli ◽  
Giulio Rasperini ◽  
Stephen E. Feinberg ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

scholarly journals Bioprinted Vascularized Mature Adipose Tissue with Collagen Microfibers for Soft Tissue Regeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Fiona Louis ◽  
Marie Piantino ◽  
Hao Liu ◽  
Dong-Hee Kang ◽  
Yoshihiro Sowa ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Large Scale ◽  
Endocrine Function ◽  
Fat Graft ◽  
Acid Uptake ◽  
Soft Tissue Regeneration ◽  
Autologous Fat Graft

The development of soft tissue regeneration has recently gained importance due to safety concerns about artificial breast implants. Current autologous fat graft implantations can result in up to 90% of volume loss in long-term outcomes due to their limited revascularization. Adipose tissue has a highly vascularized structure which enables its proper homeostasis as well as its endocrine function. Mature adipocytes surrounded by a dense vascular network are the specific features required for efficient regeneration of the adipose tissue to perform host anastomosis after its implantation. Recently, bioprinting has been introduced as a promising solution to recreate in vitro this architecture in large-scale tissues. However, the in vitro induction of both the angiogenesis and adipogenesis differentiations from stem cells yields limited maturation states for these two pathways. To overcome these issues, we report a novel method for obtaining a fully vascularized adipose tissue reconstruction using supporting bath bioprinting. For the first time, directly isolated mature adipocytes encapsulated in a bioink containing physiological collagen microfibers (CMF) were bioprinted in a gellan gum supporting bath. These multilayered bioprinted tissues retained high viability even after 7 days of culture. Moreover, the functionality was also confirmed by the maintenance of fatty acid uptake from mature adipocytes. Therefore, this method of constructing fully functional adipose tissue regeneration holds promise for future clinical applications.

INNOVATIVE REGENERATIVE ENGINEERING TECHNOLOGIES FOR SOFT TISSUE REGENERATION

2014 ◽  
Vol 16 (3) ◽  
pp. 195-214
Author(s):  
Roshan James ◽  
Matthew D. Harmon ◽  
Sangamesh G. Kumbar ◽  
Cato T. Laurencin
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Regenerative Engineering ◽  
Soft Tissue Regeneration

scholarly journals Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization

2021 ◽  
Vol 6 (11) ◽  
pp. 4096-4109
Author(s):  
Jinchun Ye ◽  
Chang Xie ◽  
Canlong Wang ◽  
Jiayun Huang ◽  
Zi Yin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Musculoskeletal System ◽  
Macrophage Polarization ◽  
Soft Tissue Regeneration

scholarly journals Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mary Beth Wandel ◽  
Craig A. Bell ◽  
Jiayi Yu ◽  
Maria C. Arno ◽  
Nathan Z. Dreger ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Biological Tissues ◽  
Soft Tissue Regeneration ◽  
Soft Tissue Engineering ◽  
Degradation Properties ◽  
Enhance Cell Adhesion

AbstractComplex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

scholarly journals 3D Printing for Soft Tissue Regeneration and Applications in Medicine

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 336
Author(s):  
Sven Pantermehl ◽  
Steffen Emmert ◽  
Aenne Foth ◽  
Niels Grabow ◽  
Said Alkildani ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Research Area ◽  
Modern Medicine ◽  
Soft Tissue Regeneration ◽  
General Overview

The use of additive manufacturing (AM) technologies is a relatively young research area in modern medicine. This technology offers a fast and effective way of producing implants, tissues, or entire organs individually adapted to the needs of a patient. Today, a large number of different 3D printing technologies with individual application areas are available. This review is intended to provide a general overview of these various printing technologies and their function for medical use. For this purpose, the design and functionality of the different applications are presented and their individual strengths and weaknesses are explained. Where possible, previous studies using the respective technologies in the field of tissue engineering are briefly summarized.

Soft Tissue Regeneration at Natural Teeth

2022 ◽  
Vol 66 (1) ◽  
pp. 87-101
Author(s):  
Raluca Cosgarea ◽  
Alpdogan Kantarci ◽  
Andreas Stavropoulos ◽  
Nicole Arweiler ◽  
Anton Sculean
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration ◽  
Natural Teeth

Basic Principles and Current Approach for Soft Tissue Regeneration

2019 ◽  
pp. 7-15
Author(s):  
Matthias M. Aitzetmüller ◽  
Elizabeth A. Brett ◽  
Matthias Sauter ◽  
Dominik Duscher
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Current Approach ◽  
Basic Principles ◽  
Soft Tissue Regeneration
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