Diabetes Mellitus and Bone Regeneration: A Systematic Review and Meta-Analysis of Animal Studies

Abstract Background Mitochondria are essential organelles that provide energy for cellular functions, participate in cellular signaling and growth, and facilitate cell death. Based on their multifactorial roles, mitochondria are also critical in the progression of critical illnesses. Transplantation of mitochondria has been reported as a potential promising approach to treat critical illnesses, particularly ischemia reperfusion injury (IRI). However, a systematic review of the relevant literature has not been conducted to date. Here, we systematically reviewed the animal and human studies relevant to IRI to summarize the evidence for mitochondrial transplantation. Methods We searched MEDLINE, the Cochrane library, and Embase and performed a systematic review of mitochondrial transplantation for IRI in both preclinical and clinical studies. We developed a search strategy using a combination of keywords and Medical Subject Heading/Emtree terms. Studies including cell-mediated transfer of mitochondria as a transfer method were excluded. Data were extracted to a tailored template, and data synthesis was descriptive because the data were not suitable for meta-analysis. Results Overall, we identified 20 animal studies and two human studies. Among animal studies, 14 (70%) studies focused on either brain or heart IRI. Both autograft and allograft mitochondrial transplantation were used in 17 (85%) animal studies. The designs of the animal studies were heterogeneous in terms of the route of administration, timing of transplantation, and dosage used. Twelve (60%) studies were performed in a blinded manner. All animal studies reported that mitochondrial transplantation markedly mitigated IRI in the target tissues, but there was variation in biological biomarkers and pathological changes. The human studies were conducted with a single-arm, unblinded design, in which autologous mitochondrial transplantation was applied to pediatric patients who required extracorporeal membrane oxygenation (ECMO) for IRI–associated myocardial dysfunction after cardiac surgery. Conclusion The evidence gathered from our systematic review supports the potential beneficial effects of mitochondrial transplantation after IRI, but its clinical translation remains limited. Further investigations are thus required to explore the mechanisms of action and patient outcomes in critical settings after mitochondrial transplantation. Systematic review registration The study was registered at UMIN under the registration number UMIN000043347.

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Anaemia and its associated factors among diabetes mellitus patients in Ethiopia: A systematic review and meta‐analysis

Endocrinology Diabetes & Metabolism ◽

10.1002/edm2.260 ◽

2021 ◽

Author(s):

Tiruneh Adane ◽

Solomon Getawa

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Associated Factors ◽

Meta Analysis

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A systematic review and meta-analysis of gestational diabetes mellitus and mental health among BAME populations

EClinicalMedicine ◽

10.1016/j.eclinm.2021.101016 ◽

2021 ◽

Vol 38 ◽

pp. 101016

Author(s):

Gayathri Delanerolle ◽

Peter Phiri ◽

Yutian Zeng ◽

Kathleen Marston ◽

Nicola Tempest ◽

...

Keyword(s):

Mental Health ◽

Diabetes Mellitus ◽

Systematic Review ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Meta Analysis

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