Acceleration of Healing of Traumatic Tympanic Membrane Perforation in Rats by Implanted Collagen Membrane Integrated with Collagen-Binding Basic Fibroblast Growth Factor

2017 ◽  
Vol 23 (1-2) ◽  
pp. 20-29 ◽  
Author(s):  
Dan Zhang ◽  
Zhen Huang ◽  
Peng Sun ◽  
Haiping Huang ◽  
Yunmei Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tympanic Membrane ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Tympanic Membrane Perforation ◽  
Collagen Membrane ◽  
Fibroblast Growth ◽  
Collagen Binding ◽  
Membrane Perforation

Regenerative treatment for tympanic membrane perforation using gelatin sponge with basic fibroblast growth factor

2017 ◽  
Vol 44 (6) ◽  
pp. 664-671 ◽  
Author(s):  
Kaoru Omae ◽  
Shin-ichi Kanemaru ◽  
Eiji Nakatani ◽  
Hideaki Kaneda ◽  
Tsutomu Nishimura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tympanic Membrane ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Tympanic Membrane Perforation ◽  
Gelatin Sponge ◽  
Fibroblast Growth ◽  
Membrane Perforation

Regeneration of the tympanic membrane using fibroblast growth factor-2

2018 ◽  
Vol 132 (06) ◽  
pp. 470-478 ◽  
Author(s):  
Z-C Lou ◽  
Z-H Lou ◽  
J Xiao
Keyword(s):  
Growth Factor ◽  
Success Rate ◽  
Tympanic Membrane ◽  
Fibroblast Growth Factor ◽  
Tympanic Membrane Perforation ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Tympanic Membrane Perforations ◽  
Membrane Perforation ◽  
Chronic Tympanic Membrane Perforation

AbstractObjectiveA systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation.MethodsThe PubMed database was searched for relevant studies. Experimental studies, human randomised controlled trials, prospective single-arm studies and retrospective studies reporting acute and chronic tympanic membrane perforations in relation to two healing outcomes (success rate and closure time), were selected.ResultsAll 11 clinical studies investigating the effect of fibroblast growth factor-2 on traumatic tympanic membrane perforations in humans reported a success rate of 89.3–100 per cent, with a closure time of around 2 weeks. Three studies of fibroblast growth factor-2 combined with Gelfoam showed that the success rate of chronic tympanic membrane perforation was 83–98.1 per cent in the fibroblast growth factor-2 group, but 10 per cent in the gelatine sponge groups.ConclusionFibroblast growth factor-2 with or without biological material patching promotes regeneration in cases of acute and chronic tympanic membrane perforation, and is safe and efficient. However, the best dosage, application time and administration pathway of fibroblast growth factor-2 are still to be elucidated.

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