Differential Effects of Small Molecule WNT Agonists on the Multilineage Differentiation Capacity of Human Mesenchymal Stem Cells

2016 ◽  
Vol 22 (21-22) ◽  
pp. 1264-1273 ◽  
Author(s):  
Roberto Narcisi ◽  
Ozan H. Arikan ◽  
Johannes Lehmann ◽  
Derk ten Berge ◽  
Gerjo J.V.M. van Osch
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Small Molecule ◽  
Human Mesenchymal Stem Cells ◽  
Multilineage Differentiation ◽  
Differentiation Capacity ◽  
Differential Effects

Differential Effects of X-Rays and High-Energy 56Fe Ions on Human Mesenchymal Stem Cells

2009 ◽  
Vol 73 (3) ◽  
pp. 869-877 ◽  
Author(s):  
Kyle Kurpinski ◽  
Deok-Jin Jang ◽  
Sanchita Bhattacharya ◽  
Bjorn Rydberg ◽  
Julia Chu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
High Energy ◽  
X Rays ◽  
Differential Effects

Noninvasive MRI and multilineage differentiation capability of ferritin-transduced human mesenchymal stem cells

2014 ◽  
Vol 28 (2) ◽  
pp. 168-179 ◽  
Author(s):  
Hoe Suk Kim ◽  
Jisu Woo ◽  
YoonSeok Choi ◽  
Eun Hye Hwang ◽  
Sul Ki Choi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Multilineage Differentiation

scholarly journals Identification of the small molecule compound which induces hepatic differentiation of human mesenchymal stem cells

2015 ◽  
Vol 2 ◽  
pp. 32-41 ◽  
Author(s):  
Noriko Itaba ◽  
Tomohiko Sakabe ◽  
Keita Kanki ◽  
Junya Azumi ◽  
Hiroki Shimizu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Small Molecule ◽  
Human Mesenchymal Stem Cells ◽  
Hepatic Differentiation ◽  
Small Molecule Compound

scholarly journals Ultrasensitive in Vivo Fluorescence Imaging of Mesenchymal Stem Cells and Small Molecule-Induced Pluripotent Stem Cells in BALB/c mice.

2021 ◽  
Author(s):  
Sang Yeon Lee ◽  
Ho-Seong Han ◽  
Sang Tae Kim ◽  
Tae Hyun Kim ◽  
Kye Ho Lee
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Injection Site ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Clinical Studies ◽  
Human Mesenchymal Stem Cells ◽  
Multipotent Stem Cells ◽  
The Brain

Abstract BackgroundMesenchymal cell has been frequently used in clinical studies. Mesenchymal stem cells (MSCs) are self-renewing, multipotent stem cells with the potential to differentiate into multiple mesoderm lineages. But MSC have limitation in clinical application for treating human diseases because they can differentiate several types of cell but not all types. PSL (Pluripotent Stem cell Like cell) are newly developed pluripotent stem cells from human mesenchymal stem cells (hMSC) induced by small molecule compounds. These cells have potential advantages for clinical cell treatment compared with ESCs and iPSCs.MethodsWe induced pluripotency from MSC using small molecules. It has tried to trace MSC and PSL in mice using bioluminescent techniques, which can detect visible light emitted from cells labeled with miRNA conjugated fluorescent molecules. ResultsMSCs predominantly migrate into the brain and testis. They also migrate to the liver, omentum, mesentery, kidneys and spleen. Migration of PSL is similar to MSCs, in that they go to the brain, testis and other intraperitoneal organs. Fluorescent images of explanted organs show that the intensity of brain images is higher in the PSL mouse group than the MSC mouse group. However, testis, image intensity is higher in MSC mouse group than the PSL mouse group. In PSL but not MSC mice, fluorescence persisted at the injection site in the tail.ConclusionsIn this study, injected MSCs and PSL predominantly migrated to the brain and testis. But, PSL migration was more than MSC migration in Brain. Both cell types had a similar migration pattern except for persistent fluorescence at injection site in the tail vein of PSL mice. We expect these cell therapy may have many potentials for clinical studies on these notable treatments.

scholarly journals Characterization of Human Mesenchymal Stem Cells from Different Tissues and Their Membrane Encasement for Prospective Transplantation Therapies

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Eva Schmelzer ◽  
Daniel T. McKeel ◽  
Jörg C. Gerlach
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Cell Fusion ◽  
Human Mesenchymal Stem Cells ◽  
Surface Markers ◽  
Multilineage Differentiation ◽  
Differentiation Potential ◽  
Donor Cells ◽  
Different Tissues

Human mesenchymal stem cells can be isolated from various organs and are in studies on therapeutic cell transplantation. Positive clinical outcomes of transplantations have been attributed to both the secretion of cytokines and growth factors as well as the fusion of donor cells with that of the host. We compared human mesenchymal stem cells from six different tissues for their transplantation-relevant potential. Furthermore, for prospective allogenic transplantation we developed a semipermeable hollow-fiber membrane enclosure, which would prevent cell fusion, would provide an immune barrier, and would allow for easy removal of donor cells from patients after recovery. We investigated human mesenchymal stem cells from adipose tissue, amniotic tissue, bone marrow, chorionic tissue, liver, and umbilical cord. We compared their multilineage differentiation potential, secretion of growth factors, and the expression of genes and surface markers. We found that although the expression of typical mesenchymal stem cell-associated gene THY1 and surface markers CD90 and CD73 were mostly similar between mesenchymal stem cells from different donor sites, their expression of lineage-specific genes, secretion of growth factors, multilineage differentiation potential, and other surface markers were considerably different. The encasement of mesenchymal stem cells in fibers affected the various mesenchymal stem cells differently depending on their donor site. Conclusively, mesenchymal stem cells isolated from different tissues were not equal, which should be taken into consideration when deciding for optimal sourcing for therapeutic transplantation. The encasement of mesenchymal stem cells into semipermeable membranes could provide a physical immune barrier, preventing cell fusion.

scholarly journals Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

2019 ◽  
Vol 60 (8) ◽  
pp. 3013 ◽  
Author(s):  
Aurelie Dos Santos ◽  
Alis Balayan ◽  
Martha L. Funderburgh ◽  
John Ngo ◽  
James L. Funderburgh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Differentiation Capacity
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