scholarly journals Nanofiber Orientation and Surface Functionalization Modulate Human Mesenchymal Stem Cell Behavior In Vitro

2014 ◽  
Vol 20 (1-2) ◽  
pp. 398-409 ◽  
Author(s):  
Yash M. Kolambkar ◽  
Mehmet Bajin ◽  
Abigail Wojtowicz ◽  
Dietmar W. Hutmacher ◽  
Andrés J. García ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Surface Functionalization ◽  
Human Mesenchymal Stem Cell ◽  
Cell Behavior

Biomaterials Nano Geometry for Control of Stem Cell Differentiation

2009 ◽  
Vol 1239 ◽  
Author(s):  
Karla Brammer ◽  
Seunghan Oh ◽  
Sungho Jin
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Oxide Surface ◽  
Specific Cell ◽  
Implant Surface ◽  
Multipotent Stem Cells

AbstractTwo important goals in stem cell research are to control the cell proliferation without differentiation, and also to direct the differentiation into a specific cell lineage when desired. Recent studies indicate that the nanostructures substantially influence the stem cell behavior. It is well known that mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into stromal lineages such as adipocyte, chondrocyte, fibroblast, myocyte, and osteoblast cell types. By examining the cellular behavior of MSCs cultured in vitro on nanostructures, some understanding of the effects that the nanostructures have on the stem cell’s response has been obtained. Here we demonstrate that TiO2 nanotubes produced by anodization on Ti implant surface can regulate human mesenchymal stem cell (hMSC) differentiation towards an osteoblast lineage in the absence of osteogenic inducing factors. Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion at smaller diameter levels or a specific differentiation of hMSCs into osteoblasts using only the geometric cues. Small (˜30 nm diameter) nanotubes promoted adhesion without noticeable differentiation, while larger (˜70 - 100 nm diameter) nanotubes elicited a dramatic, ˜10 fold stem cell elongation, which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for novel orthopaedics-related hMSC treatments. The fact that a guided and preferential osteogenic differentiation of stem cells can be achieved using substrate nanotopography alone without using potentially toxic, differentiation-inducing chemical agents is significant, which can be useful for future development of novel and enhanced stem cell control and therapeutic implant development.

Effects of Hydrostatic Pressure and Transforming Growth Factor-β3 on Adult Human Mesenchymal Stem Cell Chondrogenesis In Vitro

2006 ◽  
Vol 12 (6) ◽  
pp. 1419-1428 ◽  
Author(s):  
Keita Miyanishi ◽  
Michael C.D. Trindade ◽  
Derek P. Lindsey ◽  
Gary S. Beaupré ◽  
Dennis R. Carter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Hydrostatic Pressure ◽  
Mesenchymal Stem Cell ◽  
Transforming Growth Factor ◽  
Human Mesenchymal Stem Cell ◽  
Adult Human

scholarly journals Human mesenchymal stem cell behavior on segmented polyurethanes prepared with biologically active chain extenders

2015 ◽  
Vol 27 (2) ◽  
Author(s):  
Taylor E. Kavanaugh ◽  
Amy Y. Clark ◽  
Lerma H. Chan-Chan ◽  
Maricela Ramírez-Saldaña ◽  
Rossana F. Vargas-Coronado ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Biologically Active ◽  
Cell Behavior ◽  
Chain Extenders ◽  
Segmented Polyurethanes

Gelatin- and starch-based hydrogels. Part B: In vitro mesenchymal stem cell behavior on the hydrogels

2017 ◽  
Vol 161 ◽  
pp. 295-305 ◽  
Author(s):  
Ine Van Nieuwenhove ◽  
Achim Salamon ◽  
Stefanie Adam ◽  
Peter Dubruel ◽  
Sandra Van Vlierberghe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Behavior

Human Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation in Fibrin Gels in Vitro

2006 ◽  
Vol 0 (0) ◽  
pp. 060802052515008
Author(s):  
Isabelle Catelas ◽  
Nadjah Sese ◽  
Benjamin M. Wu ◽  
James C.Y. Dunn ◽  
Sam Helgerson ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Fibrin Gels ◽  
Stem Cell Proliferation

Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro

2020 ◽  
Vol 200 ◽  
pp. 108212
Author(s):  
Leandro C. Teixeira-Pinheiro ◽  
Maria F. Toledo ◽  
Gabriel Nascimento-dos-Santos ◽  
Rosalia Mendez-Otero ◽  
Louise A. Mesentier-Louro ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Paracrine Signaling ◽  
Population Number ◽  
Retinal Microglia
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