scholarly journals Fabrication of Blended Polycaprolactone/Poly (Lactic-Co-Glycolic Acid)/β-Tricalcium Phosphate Thin Membrane Using Solid Freeform Fabrication Technology for Guided Bone Regeneration

2013 ◽  
Vol 19 (3-4) ◽  
pp. 317-328 ◽  
Author(s):  
Jin-Hyung Shim ◽  
Jung-Bo Huh ◽  
Ju Young Park ◽  
Young-Chan Jeon ◽  
Seong Soo Kang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Glycolic Acid ◽  
Solid Freeform Fabrication ◽  
Guided Bone Regeneration ◽  
Thin Membrane ◽  
Fabrication Technology ◽  
Freeform Fabrication

Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application

2020 ◽  
Vol 86 ◽  
pp. 106489 ◽  
Author(s):  
Vanessa Oliveira Castro ◽  
Márcio Celso Fredel ◽  
Águedo Aragones ◽  
Guilherme Mariz de Oliveira Barra ◽  
Karina Cesca ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Glycolic Acid ◽  
Guided Bone Regeneration ◽  
Fibrous Membranes

In vitro evaluation of bilayer membranes of PLGA/hydroxyapatite/β-tricalcium phosphate for guided bone regeneration

2020 ◽  
Vol 112 ◽  
pp. 110849 ◽  
Author(s):  
Vivian Inês dos Santos ◽  
Claudia Merlini ◽  
Águedo Aragones ◽  
Karina Cesca ◽  
Márcio Celso Fredel
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Guided Bone Regeneration ◽  
Bilayer Membranes ◽  
In Vitro Evaluation

Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration

2020 ◽  
Vol 179 ◽  
pp. 109253
Author(s):  
Vivian Inês dos Santos ◽  
Claudia Merlini ◽  
Águedo Aragones ◽  
Karina Cesca ◽  
Márcio Celso Fredel
Keyword(s):  
Bone Regeneration ◽  
Glycolic Acid ◽  
Calcium Phosphates ◽  
Guided Bone Regeneration ◽  
Electrospun Membranes

A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery

2001 ◽  
Vol 58 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Anita A. Ignatius ◽  
Michael Ohnmacht ◽  
Lutz E. Claes ◽  
Joachim Kreidler ◽  
Frank Palm
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Maxillofacial Surgery ◽  
Guided Bone Regeneration ◽  
Composite Polymer

scholarly journals Fabrication and evaluation of poly(lactic acid), chitosan, and tricalcium phosphate biocomposites for guided bone regeneration

2018 ◽  
Vol 135 (39) ◽  
pp. 46692 ◽  
Author(s):  
Srikanthan Ramesh ◽  
Lisa Lungaro ◽  
Dimitrios Tsikritsis ◽  
Eric Weflen ◽  
Iris V. Rivero ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Guided Bone Regeneration ◽  
Poly Lactic Acid

Development of HA-PLGA Scaffold Encapsulating Intact BMP-2 Using Solid Freeform Fabrication Technology

2011 ◽  
Author(s):  
Jin-Hyung Shim ◽  
Jong Young Kim ◽  
Kyung Shin Kang ◽  
Jung Kyu Park ◽  
Sei Kwang Hahn ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Porous Scaffold ◽  
Solid Freeform Fabrication ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Prolonged Release ◽  
Cellular Activity ◽  
Freeform Fabrication

Tissue engineering is an interdisciplinary field that focuses on restoring and repairing tissues or organs. Cells, scaffolds, and biomolecules are recognized as three main components of tissue engineering. Solid freeform fabrication (SFF) technology is required to fabricate three-dimensional (3D) porous scaffolds to provide a 3D environment for cellular activity. SFF technology is especially advantageous for achieving a fully interconnected, porous scaffold. Bone morphogenic protein-2 (BMP-2), an important biomolecule, is widely used in bone tissue engineering to enhance bone regeneration activity. However, methods for the direct incorporation of intact BMP-2 within 3D scaffolds are rare. In this work, 3D porous scaffolds with poly(lactic-co-glycolic acid) chemically grafted hyaluronic acid (HA-PLGA), in which intact BMP-2 was directly encapsulated, were successfully fabricated using SFF technology. BMP-2 was previously protected by poly(ethylene glycol) (PEG), and the BMP-2/PEG complex was incorporated in HA-PLGA using an organic solvent. The HAPLGA/PEG/BMP-2 mixture was dissolved in chloroform and deposited via a multi-head deposition system (MHDS), one type of SFF technology, to fabricate a scaffold for tissue engineering. An additional air blower system and suction were installed in the MHDS for the solvent-based fabrication method. An in vitro evaluation of BMP-2 release was conducted, and prolonged release of intact BMP-2, for up to 28 days, was confirmed. After confirmation of advanced proliferation of pre osteoblasts, a superior differentiation effect of the HA-PLGA/PEG/BMP-2 scaffold was validated by measuring high expression levels of bone-specific markers, such as alkaline phosphatase (ALP) and osteocalcin (OC). We show that our solvent-based fabrication is a non-toxic method for restoring cellular activity. Moreover, the HAPLGA/PEG/BMP-2 scaffold was effective for bone regeneration.

scholarly journals Examination of Optimal Concentrations of Poly (Lactic-co-glycolic Acid) in Hexafluoroisopropyl Alcohol for Guided Bone Regeneration Membrane Prepared by Electrospinning

2020 ◽  
Vol 18 (3-4) ◽  
pp. 239-247
Author(s):  
Daisuke Isaji ◽  
Takehiro Watanabe ◽  
Takahiro Takahashi ◽  
Hiroki Sato ◽  
Hiroshi Nakada ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Glycolic Acid ◽  
Guided Bone Regeneration
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