scholarly journals Effect of Antioxidant Supplementation on the Total Yield, Oxidative Stress Levels, and Multipotency of Bone Marrow-Derived Human Mesenchymal Stromal Cells

2013 ◽  
Vol 19 (7-8) ◽  
pp. 928-937 ◽  
Author(s):  
Hugo Alves ◽  
Anouk Mentink ◽  
Bach Le ◽  
Clemens A. van Blitterswijk ◽  
Jan de Boer
Keyword(s):  
Oxidative Stress ◽  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Total Yield ◽  
Antioxidant Supplementation ◽  
Human Mesenchymal Stromal Cells ◽  
Stress Levels

scholarly journals Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 87
Author(s):  
Francesca Perut ◽  
Laura Roncuzzi ◽  
Sofia Avnet ◽  
Annamaria Massa ◽  
Nicoletta Zini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Mammalian Cells ◽  
Dependent Manner ◽  
Potential Health ◽  
Human Mesenchymal Stromal Cells ◽  
Health Promoting ◽  
Size And Morphology

Plant-derived exosome-like nanovesicles (EPDENs) have recently been isolated and evaluated as potential bioactive nutraceutical biomolecules. It has been hypothesized that EPDENs may exert their activity on mammalian cells through their specific cargo. In this study, we isolated and purified EPDENs from the strawberry juice of Fragaria x ananassa (cv. Romina), a new cultivar characterized by a high content of anthocyanins, folic acid, flavonols, and vitamin C and an elevated antioxidant capacity. Fragaria-derived EPDENs were purified by a series of centrifugation and filtration steps. EPDENs showed size and morphology similar to mammalian extracellular nanovesicles. The internalization of Fragaria-derived EPDENs by human mesenchymal stromal cells (MSCs) did not negatively affect their viability, and the pretreatment of MSCs with Fragaria-derived EPDENs prevented oxidative stress in a dose-dependent manner. This is possibly due to the presence of vitamin C inside the nanovesicle membrane. The analysis of EPDEN cargo also revealed the presence of small RNAs and miRNAs. These findings suggest that Fragaria-derived EPDENs may be considered nanoshuttles contained in food, with potential health-promoting activity.

scholarly journals Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102359 ◽  
Author(s):  
Adam Papadimitropoulos ◽  
Elia Piccinini ◽  
Sophie Brachat ◽  
Alessandra Braccini ◽  
David Wendt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
3D Scaffold ◽  
Human Mesenchymal Stromal Cells ◽  
Fresh Bone

The aggregate nature of human mesenchymal stromal cells in native bone marrow

Cytotherapy ◽  
2012 ◽  
Vol 14 (8) ◽  
pp. 917-924 ◽  
Author(s):  
Naser Ahmadbeigi ◽  
Masoud Soleimani ◽  
Farshad Babaeijandaghi ◽  
Yousef Mortazavi ◽  
Yousof Gheisari ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Native Bone ◽  
Human Mesenchymal Stromal Cells ◽  
Aggregate Nature

Functional recovery after transplantation of bone marrow-derived human mesenchymal stromal cells in a rat model of spinal cord injury

Cytotherapy ◽  
2010 ◽  
Vol 12 (6) ◽  
pp. 792-806 ◽  
Author(s):  
Rakhi Pal ◽  
Chaitanya Gopinath ◽  
Nagesh M Rao ◽  
Poulomi Banerjee ◽  
Venkatesh Krishnamoorthy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Mesenchymal Stromal Cells ◽  
Functional Recovery ◽  
Rat Model ◽  
Stromal Cells ◽  
Human Mesenchymal Stromal Cells ◽  
Cord Injury
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