scholarly journals Radially and Axially Graded Multizonal Bone Graft Substitutes Targeting Critical-Sized Bone Defects from Polycaprolactone/Hydroxyapatite/Tricalcium Phosphate

2012 ◽  
Vol 18 (23-24) ◽  
pp. 2426-2436 ◽  
Author(s):  
Asli Ergun ◽  
Xiaojun Yu ◽  
Antonio Valdevit ◽  
Arthur Ritter ◽  
Dilhan M. Kalyon
Keyword(s):  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Bone Graft Substitutes

An Experimental Study of Tricalcium Phosphate (TCP) as a Bone Graft Substitutes of Bone Defects in Canine Femur

1990 ◽  
Vol 25 (2) ◽  
pp. 545
Author(s):  
Ik Dong Kim ◽  
Poong Taek Kim ◽  
Byung Chul Park ◽  
Young Wook Choi ◽  
Young Goo Lyu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Bone Graft Substitutes

scholarly journals Reply to the Letter to the Editor: Adverse Reactions of Artificial Bone Graft Substitutes: Lessons Learned From Using Tricalcium Phosphate geneX®

2013 ◽  
Vol 472 (2) ◽  
pp. 767-768 ◽  
Author(s):  
Joerg Friesenbichler ◽  
Werner Maurer-Ertl ◽  
Patrick Sadoghi ◽  
Ulrike Pirker-Fruehauf ◽  
Koppany Bodo ◽  
...  
Keyword(s):  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Adverse Reactions ◽  
Lessons Learned ◽  
Artificial Bone ◽  
Letter To The Editor ◽  
Bone Graft Substitutes

Porous ceramics as bone graft substitutes in long bone defects: A biomechanical, histological, and radiographic analysis

1996 ◽  
Vol 14 (3) ◽  
pp. 351-369 ◽  
Author(s):  
Kenneth D. Johnson ◽  
Kerek E. Frierson ◽  
Tony S. Keller ◽  
Charles Cook ◽  
Robert Scheinberg ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defects ◽  
Porous Ceramics ◽  
Long Bone ◽  
Radiographic Analysis ◽  
Bone Graft Substitutes

scholarly journals Bone healing of distal radius nonunion treated with bridge plating with bone graft substitutes in combination with systemic romosozumab administration: A case report

2021 ◽  
Vol 32 (2) ◽  
pp. 526-530
Author(s):  
Takuya Uemura ◽  
Koichi Yano ◽  
Kiyohito Takamatsu ◽  
Yusuke Miyashima ◽  
Hiroyuki Yasuda ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Graft ◽  
Distal Radius ◽  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Bone Union ◽  
Heavy Smoker ◽  
Bone Graft Substitutes ◽  
Bridge Plating

Romosozumab is a humanized, anti-sclerostin monoclonal antibody used to treat osteoporosis, which increases bone formation and decreases bone resorption. It enhances fracture healing and systemic romosozumab administration may have therapeutic potentials for accelerating bone healing of even nonunion. Herein, a 61-year-old heavy smoker male with distal radius nonunion who achieved successful bone union by combination therapy of romosozumab and spanning distraction plate fixation with bone graft substitutes was presented. Through the dorsal approach, atrophic comminuted nonunion of the distal radius was sufficiently debrided. Reduction of the distal radius was performed using indirect ligamentotaxis, and a 14-hole locking plate was fixed from the third metacarpal to the radial shaft. A beta (β) tricalcium phosphate block was mainly packed into the substantial metaphyseal bone defect with additional bone graft from the resected ulnar head. Postoperatively, systemic administration of monthly romosozumab was continued for six months. Complete bone union was achieved 20 weeks postoperatively and the plate was, then, removed. Wrist extension and flexion improved to 75o and 55o, respectively, without pain, and grip strength increased 52 weeks postoperatively from 5.5 kg to 22.4 kg. During romosozumab treatment, bone formation marker levels increased rapidly and finally returned to baseline, and bone resorption marker levels remained low. In conclusion, combination of systemic romosozumab administration and grafting β-tricalcium phosphate with bridge plating provides an effective treatment option for difficult cases of comminuted distal radius nonunion with risk factors such as smoking, diabetes, and fragility.

A Histological and Radiological Study of Bone Formation around Porous Resorbable β-Tricalcium Phosphate Used as Bone Defect Filling

2014 ◽  
Vol 631 ◽  
pp. 420-425
Author(s):  
M. Strnadová ◽  
T. Kučera ◽  
M.D. Cevallos Lecaro ◽  
J. Strnad ◽  
Z. Strnad ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Metallic Material ◽  
Bone Graft Substitutes ◽  
Autologous Bone ◽  
Benign Tumours ◽  
Autologous Bone Grafts ◽  
Defect Filling

The purpose of this study was to analyze the histological, histochemical and radiological findings gained from pre-clinical in vitro and in vivo tests and from implantation of ß-tricalcium phosphate PORESORB®-TCP (P). (P) is a bioactive, resorbable, inorganic, crystalline, non-metallic material with osseoconductive properties intended for replacement of bone tissue. The (P) granules (size 1-2mm) were implanted into the tibia of dogs for 3 and 6 months. The formation of 53% and 72% of new bone was observed after 3 and 6 months respectively.Material (P) sized 0.3-0.6 mm was used to fill in the periodontal defect and also as a carrier of growth proteins. During the study period, no undesired response to the material used was observed. The values of the plaque index showed standard hygienic conditions – the values of PlI were 0.72, 0.65 and 0.62 before treatment and 6 and 12 months after treatment, respectively.A total of 72 two-stage sinus lifts were performed in 54 patients. The autologous bone was harvested from the mandibular ramus and mixed with the (P) material sized 1-2 mm. The materials were used in a proportion ranging between 1: 1 and 1: 3. The residual allograft area was 16.21 ± 8.78 %. The connective tissue was 44.16 ± 5.85 %.This has been a retrospective review of the healing of bone defects, due to benign tumours or tumour-like lesions, using (P) material sized 1.3 mm, 0.7 mm (0.6-2 mm) as bone graft substitutes. 87 patients with bone defects (average volume 15 cm3; interval 0.4 – 144 cm3) were included. Defects with a volume up to 4 cm3 had the same successful rate of healing both for autologous bone grafts and (P). (P) sized 1.3 mm; 0.7 mm (0.6-2 mm) was successfully used in defects with volume up to 4 cm3. However, it is evident that the ratio of the size of the defect and the size of the applied granule must be kept near to 10/1 for successful treatment.

scholarly journals Adverse Reactions of Artificial Bone Graft Substitutes: Lessons Learned From Using Tricalcium Phosphate geneX®

2013 ◽  
Vol 472 (3) ◽  
pp. 976-982 ◽  
Author(s):  
Joerg Friesenbichler ◽  
Werner Maurer-Ertl ◽  
Patrick Sadoghi ◽  
Ulrike Pirker-Fruehauf ◽  
Koppany Bodo ◽  
...  
Keyword(s):  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Adverse Reactions ◽  
Lessons Learned ◽  
Artificial Bone ◽  
Bone Graft Substitutes
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