scholarly journals Platelet-Rich Plasma: Quantification of Growth Factor Levels and the Effect on Growth and Differentiation of Rat Bone Marrow Cells

2006 ◽  
Vol 12 (11) ◽  
pp. 3067-3073 ◽  
Author(s):  
Juliette Van Den Dolder ◽  
Rob Mooren ◽  
Annelies P.G. Vloon ◽  
Paul J.W. Stoelinga ◽  
John A. Jansen
2006 ◽  
Vol 0 (0) ◽  
pp. 061004065151006
Author(s):  
Juliette Van Den Dolder ◽  
Rob Mooren ◽  
Annelies P.G. Vloon ◽  
Paul J.W. Stoelinga ◽  
John A. Jansen

2000 ◽  
Vol 279 (2) ◽  
pp. 500-504 ◽  
Author(s):  
Seh-Hoon Oh ◽  
Masahiro Miyazaki ◽  
Hirosuke Kouchi ◽  
Yusuke Inoue ◽  
Masakiyo Sakaguchi ◽  
...  

2019 ◽  
Vol 19 (14) ◽  
pp. 1695-1702 ◽  
Author(s):  
Mohsen Cheki ◽  
Salman Jafari ◽  
Masoud Najafi ◽  
Aziz Mahmoudzadeh

Background and Objective: Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In the present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. Methods: Glucosamine was orally administrated to rats at doses of 75 and 150 mg/kg body weight for seven consecutive days. On the seventh day, the rats were treated with a single injection of cisplatin (5 mg/kg, i.p.) at 1h after the last oral administration. The cisplatin antagonistic potential of glucosamine was assessed by micronucleus assay, Reactive Oxygen Species (ROS) level analysis, hematological analysis, and flow cytometry. Results: Glucosamine administration to cisplatin-treated rats significantly decreased the frequencies of Micronucleated Polychromatic Erythrocytes (MnPCEs) and Micronucleated Normchromatic Erythrocytes (MnNCEs), and also increased PCE/(PCE+NCE) ratio in bone marrow cells. Furthermore, treatment of rats with glucosamine before cisplatin significantly inhibited apoptosis, necrosis and ROS generation in bone marrow cells, and also increased red blood cells count in peripheral blood. Conclusion: This study shows glucosamine to be a new effective chemoprotector against cisplatin-induced DNA damage and apoptosis in rat bone marrow cells. The results of this study may be helpful in reducing the harmful effects of cisplatin-based chemotherapy in the future.


2011 ◽  
Vol 147 (1-3) ◽  
pp. 261-266 ◽  
Author(s):  
Ye Tian ◽  
Jiexiu Zhao ◽  
Binxiu Zhao ◽  
Qi Gao ◽  
Jincheng Xu ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document