The Potential Use of Enamel Matrix Derivative for In Situ Anterior Cruciate Ligament Tissue Engineering: A Translational In Vitro Investigation

2007 ◽  
Vol 13 (8) ◽  
pp. 2041-2051 ◽  
Author(s):  
Michael P. Messenger ◽  
El Mustafa Raif ◽  
Bahaa B. Seedhom ◽  
Steven J. Brookes
Keyword(s):  
Tissue Engineering ◽  
Cruciate Ligament ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
In Vitro Investigation ◽  
Anterior Cruciate ◽  
Potential Use ◽  
Matrix Derivative

Effect of the enamel matrix derivative Emdogain® on the growth of periodontal pathogens in vitro

2002 ◽  
Vol 29 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Axel Spahr ◽  
Staale Petter Lyngstadaas ◽  
Clemens Boeckh ◽  
Christer Andersson ◽  
Andreas Podbielski ◽  
...  
Keyword(s):  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Pathogens ◽  
Matrix Derivative

REGENERATION OF ANTERIOR CRUCIATE LIGAMENT WITH SILK-BASED SCAFFOLD IN PORCINE MODEL

2015 ◽  
Vol 15 (01) ◽  
pp. 1550006 ◽  
Author(s):  
ZHENG LI ◽  
JIANKANG HE ◽  
XIANG LI ◽  
WEIGUO BIAN ◽  
WENYOU ZHANG ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Anterior Cruciate Ligament ◽  
Porcine Model ◽  
Cruciate Ligament ◽  
Silk Fibers ◽  
Bone Interface ◽  
Anterior Cruciate ◽  
Large Animals

Silk was widely investigated as a promising scaffold material in ligament tissue engineering. Although a variety of silk scaffolds were developed for the regeneration of anterior cruciate ligament (ACL) in vitro and in vivo, more investigations should be performed in large animals to translate these findings into clinical applications. The aim of this study is to evaluate the feasibility of using silk-based ACL scaffolds to regenerate damaged ACLs in porcine model. The microstructural organization, tissue regeneration as well as ligament-bone interface of silk implants were evaluated with scanning electron microscopy, micro-computerized tomography, histological and immunohistochemical staining at three and six months postoperatively. The results demonstrated that silk fibers in the ACL scaffolds organized in parallel similar with collagen fibers in native ligaments, which facilitated and guided the penetration of newly regenerated tissue into the pores among silk fibers. Collagen production especially collagen I in silk implants significantly increased from three to six months, and was gradually close to the level of native ligaments. At implant-bone interface, indirect ligament-bone insertion was observed at three months and substantial Sharpey's fibers formed at six months. The results indicated that the silk-based ACL scaffold provides a promising tissue engineering approach for ACL regeneration.

In Vitro Evaluation of Demineralized Freeze-Dried Bone Allograft in Combination With Enamel Matrix Derivative

2013 ◽  
pp. 1-9 ◽  
Author(s):  
Richard J. Miron ◽  
Dieter Bosshardt ◽  
Oliver Laugisch ◽  
Michel Dard ◽  
Anja C. Gemperli ◽  
...  
Keyword(s):  
Bone Allograft ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
In Vitro Evaluation ◽  
Freeze Dried ◽  
Matrix Derivative

Influence of Enamel Matrix Derivative on Human Epithelial Cells In Vitro

2016 ◽  
Vol 87 (10) ◽  
pp. 1217-1227 ◽  
Author(s):  
Sabine Groeger ◽  
Anita Windhorst ◽  
Joerg Meyle
Keyword(s):  
Epithelial Cells ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Human Epithelial Cells ◽  
Matrix Derivative

Effects of enamel matrix derivative on periodontal wound healing in an inflammatory environment in vitro

2011 ◽  
Vol 38 (5) ◽  
pp. 479-490 ◽  
Author(s):  
Marjan Nokhbehsaim ◽  
Jochen Winter ◽  
Birgit Rath ◽  
Andreas Jäger ◽  
Søren Jepsen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Wound Healing ◽  
Matrix Derivative
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