In Vivo Degradation and Release Kinetics of Chloramphenicol-Loaded Poly(D,L)-Lactide Sponges

1998 ◽  
Vol 4 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Canan Taş ◽  
Ahmet Kozluca ◽  
Mehmet Alİ Onur ◽  
AşKin Tümer ◽  
Haldun Vahapoǧlu ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Kinetics Of ◽  
In Vivo Degradation

scholarly journals Drug Release Kinetics of Electrospun PHB Meshes

Materials ◽  
2019 ◽  
Vol 12 (12) ◽  
pp. 1924 ◽  
Author(s):  
Vojtech Kundrat ◽  
Nicole Cernekova ◽  
Adriana Kovalcik ◽  
Vojtech Enev ◽  
Ivana Marova
Keyword(s):  
Release Kinetics ◽  
Entrapment Efficiency ◽  
Toxic Substances ◽  
Antimicrobial Efficiency ◽  
Vis Spectroscopy ◽  
Model Drug ◽  
Phosphate Buffered Saline ◽  
Kinetics Of

Microbial poly(3-hydroxybutyrate) (PHB) has several advantages including its biocompatibility and ability to degrade in vivo and in vitro without toxic substances. This paper investigates the feasibility of electrospun PHB meshes serving as drug delivery systems. The morphology of the electrospun samples was modified by varying the concentration of PHB in solution and the solvent composition. Scanning electron microscopy of the electrospun PHB scaffolds revealed the formation of different morphologies including porous, filamentous/beaded and fiber structures. Levofloxacin was used as the model drug for incorporation into PHB electrospun meshes. The entrapment efficiency was found to be dependent on the viscosity of the PHB solution used for electrospinning and ranged from 14.4–81.8%. The incorporation of levofloxacin in electrospun meshes was confirmed by Fourier-transform infrared spectroscopy and UV-VIS spectroscopy. The effect of the morphology of the electrospun meshes on the levofloxacin release profile was screened in vitro in phosphate-buffered saline solution. Depending upon the morphology, the electrospun meshes released about 14–20% of levofloxacin during the first 24 h. The percentage of drug released after 13 days increased up to 32.4% and was similar for all tested morphologies. The antimicrobial efficiency of all tested samples independent of the morphology, was confirmed by agar diffusion testing.

Crosslinked Chitosan/PVA Film, Suturated with 5- Fluorouracil for The Prevention of Proliferative Vitreoretinopathy

2016 ◽  
Vol 6 (2) ◽  
Author(s):  
Baiyrkhanova A. ◽  
Ismailova A. ◽  
Botabekova T. ◽  
Enin E. ◽  
Semenova Y.
Keyword(s):  
Proliferative Vitreoretinopathy ◽  
Release Kinetics ◽  
Drug Loading ◽  
In Vitro Release ◽  
Chemical Compositions ◽  
Ophthalmic Administration ◽  
Model Drug ◽  
Kinetics Of

5-Fluorouracil (5-FU)-loaded chitosan (Ch) film for chemotherapy were prepared applying a superhydrophobic surfacebased encapsulation technology. The aim of this study was to develop polymeric film with glutaraldehyde (GA) of controlled drug delivery systems for 5 – fluorouracil (FU) as a model drug for the treatment of proliferative vitreoretinopathy. Polymer film of chitosan and polyvinyl alcohol (PVA in 75:25 ratios were prepared and treated with GA. FTIR spectra of 5-FU, Ch/5-FU and Ch/PVA film loaded 5-FU were studied. Physical characteristics such as thickness and swelling coefficient of the film were performed. The thermal of the Ch/PVA film was studied with thermogravimethric analysis. The drug loading efficiency, film size and chemical compositions of the film loaded drug were confirmed by UV–vis spectrophotometer and Fourier transform infrared spectroscopy. In vitro release kinetics of drug from the polymeric films was investigated to determine the drug release properties. In vivo study of PVR was showed the efficacy and no toxicity of this formulation. Further uses of the film loaded 5 - fluorouracil may provide an efficiency deliverable for ophthalmic administration.

In vivo degradation kinetics of Elymus nutans from the Tibetan plateau

2011 ◽  
Vol 96 (2-3) ◽  
pp. 140-143
Author(s):  
Jun Wei ◽  
Zhong-Hua Cao ◽  
Yan Jing ◽  
Zhong-yue zhang
Keyword(s):  
Tibetan Plateau ◽  
Degradation Kinetics ◽  
The Tibetan Plateau ◽  
Elymus Nutans ◽  
Kinetics Of ◽  
In Vivo Degradation

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

2019 ◽  
Vol 310 ◽  
pp. 82-93 ◽  
Author(s):  
Kaushik Thanki ◽  
Delphine van Eetvelde ◽  
Antonia Geyer ◽  
Juan Fraire ◽  
Remi Hendrix ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Hybrid Nanoparticles ◽  
Pulmonary Administration ◽  
Polymer Hybrid ◽  
Kinetics Of

Evaluation and comparison of in vitro and in vivo degradation kinetics of magnesium

2013 ◽  
Author(s):  
Muhammad Imran Rahim ◽  
Peter P. Mueller ◽  
Manfred Rohde ◽  
Hansjörg Hauser
Keyword(s):  
Degradation Kinetics ◽  
Kinetics Of ◽  
In Vivo Degradation

scholarly journals Oxo-M and 4-PPBP Delivery via Multi-Domain Peptide Hydrogel Toward Tendon Regeneration

2021 ◽  
Author(s):  
Ga Young Park ◽  
Solaiman Tarafder ◽  
Samantha Lewis ◽  
Soomin Park ◽  
Ryunhyung Park ◽  
...  
Keyword(s):  
Small Molecules ◽  
Release Kinetics ◽  
Tendon Healing ◽  
Tendon Regeneration ◽  
Tenogenic Differentiation ◽  
Domain Peptide ◽  
Kinetics Of

AbstractWe have recently identified novel small molecules, Oxo-M and 4-PPBP, which specifically stimulates endogenous tendon stem/progenitor cells (TSCs) leading to potential regenerative healing of fully-transected tendons. Here we investigated an injectable, multi-domain peptide (MDP) hydrogel providing a controlled delivery of the small molecules for regenerative tendon healing. We investigated the release kinetics of Oxo-M and 4-PPBP from MDP hydrogels and the effect of MDP-released small molecules on tenogenic differentiation of TSCs and in vivo tendon healing. In vitro, MDP showed a sustained release of Oxo-M and 4-PPBP and a slower degradation compared to fibrin. In addition, tenogenic gene expression was significantly increased in TSC with MDP-released Oxo-M and 4-PPBP as compared to the fibrin-released. In vivo, MDP releasing Oxo-M and 4-PPBP significantly improved tendon healing, likely associated with prolonged effects of Oxo-M and 4-PPBP on suppression of M1 macrophages and promotion of M2 macrophages. Comprehensive analyses including histomorphology, digital image processing, and modulus mapping with nanoindentation consistently suggested that Oxo-M and 4-PPBP delivered via MDP further improved tendon healing as compared to fibrin-based delivery. In conclusion, MDP delivered with Oxo-M and 4-PPBP may serve as an efficient regenerative therapeutic for in situ tendon regeneration and healing.

scholarly journals In vivo degradation kinetics of Tibetan forage

2010 ◽  
Vol 9 (2) ◽  
Author(s):  
Tian-Ming Hu ◽  
Zhong-Hua Cao ◽  
Jun Wei ◽  
She-Hui Cao ◽  
Yan Jing ◽  
...  
Keyword(s):  
Degradation Kinetics ◽  
Kinetics Of ◽  
In Vivo Degradation

scholarly journals Pectin-Based Nanomaterials: Synthesis, Toxicity and Applications

2021 ◽  
Vol 33 (11) ◽  
pp. 2579-2588
Author(s):  
Mandeep Kaur ◽  
Aditya Wadhwa ◽  
Vineet Kumar
Keyword(s):  
Drug Delivery ◽  
Human Body ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Biological Origin ◽  
Nanomaterials Synthesis ◽  
The Stability ◽  
Kinetics Of

Nanomaterials of biological origin are very useful for drug delivery applications. The stability, biodegradability and biocompatibility of pectin nanomaterials in the human body make them an effective drug carrier. This review focus on different aspect of synthesis, drug encapsulation, drug release and safety of pectin-based nanomaterials. The nanomaterials can be used for the delivery of different hydrophilic and hydrophobic drugs to various organs. The release kinetics of drug loaded pectin-based nanoparticles can be studied in vitro as well as in vivo. The pectin-based nanomaterials have good pharmaco-kinetics and can ensure controlled drug delivery. However, the toxicity of pectin-based nanomaterials to human body needs to be evaluated carefully before industrial scale application.

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