Extramedullary Chitosan Channels Promote Survival of Transplanted Neural Stem and Progenitor Cells and Create a Tissue Bridge After Complete Spinal Cord Transection

2008 ◽  
Vol 14 (5) ◽  
pp. 649-665 ◽  
Author(s):  
Hiroshi Nomura ◽  
Tasneem Zahir ◽  
Howard Kim ◽  
Yusuke Katayama ◽  
Iris Kulbatski ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Progenitor Cells ◽  
Spinal Cord Transection ◽  
Stem And Progenitor Cells

scholarly journals Cell replacement therapy in neurological disease

2006 ◽  
Vol 361 (1473) ◽  
pp. 1463-1475 ◽  
Author(s):  
Steven A Goldman ◽  
Martha S Windrem
Keyword(s):  
Spinal Cord ◽  
Progenitor Cells ◽  
Cell Types ◽  
Therapeutic Benefit ◽  
Lysosomal Storage ◽  
Neuronal Progenitor ◽  
Cell Based Therapy ◽  
Cord Injury ◽  
Stem And Progenitor Cells ◽  
Myelin Disorders

Diseases of the brain and spinal cord represent especially daunting challenges for cell-based strategies of repair, given the multiplicity of cell types within the adult central nervous system, and the precision with which they must interact in both space and time. Nonetheless, a number of diseases are especially appropriate for cell-based therapy, in particular those in which single phenotypes are lost, and in which the re-establishment of vectorially specific connections is not entirely requisite for therapeutic benefit. We review here a set of potential therapeutic indications that meet these criteria as potentially benefiting from the transplantation of neural stem and progenitor cells. These include: (i) transplantation of phenotypically restricted neuronal progenitor cells into diseases of a single neuronal phenotype, such as Parkinson's disease; (ii) implantation of mixed progenitor pools into diseases characterized by the loss of a limited number of discrete phenotypes, such as spinal cord injury and the motor neuronopathies; (iii) transplantation of glial and nominally oligodendrocytic progenitor cells as a means of treating disorders of myelin; and (iv) transplantation of neural stem cells as a means of treating lysosomal storage disorders and other diseases of enzymatic deficiency. Among the diseases potentially approachable by these strategies, the myelin disorders, including the paediatric leucodystrophies as well as adult traumatic and inflammatory demyelinations, may present the most compelling targets for cell-based neurological therapy.

scholarly journals Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2045
Author(s):  
Zachary Finkel ◽  
Fatima Esteban ◽  
Brianna Rodriguez ◽  
Tianyue Fu ◽  
Xin Ai ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Extracellular Matrix ◽  
Cerebrospinal Fluid ◽  
Growth Factors ◽  
Energy Metabolism ◽  
Progenitor Cells ◽  
Ependymal Cells ◽  
Stem And Progenitor Cells ◽  
The Brain

Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master transcription factors, and mechanical properties of the extracellular matrix (ECM), collectively regulate activities and characteristics of NSPCs: quiescence/survival, proliferation, migration, differentiation, and integration. This review discusses the heterogeneous NSPC populations in the normal physiology and highlights their potentials and roles in injured/diseased states for regenerative medicine.

scholarly journals Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease

2021 ◽  
Author(s):  
Zachary Finkel ◽  
FATIMA ESTEBAN ◽  
Brianna Rodriguez ◽  
TIANYUE FU ◽  
Xin Ai ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Extracellular Matrix ◽  
Cerebrospinal Fluid ◽  
Growth Factors ◽  
Energy Metabolism ◽  
Progenitor Cells ◽  
Ependymal Cells ◽  
Stem And Progenitor Cells ◽  
The Brain

Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master transcription factors, and mechanical properties of the extracellular matrix (ECM), collectively regulate activities and characteristics of NSPCs: quiescence/survival, proliferation, migration, differentiation, and integration. This review discusses the heterogeneous NSPC populations in the normal physiology and highlights their potentials and roles in injured/diseased states for regenerative medicine.

Flow cytometric enumeration and immunophenotyping of hematopoietic stem and progenitor cells

2001 ◽  
Vol 38 (2) ◽  
pp. 139-147
Author(s):  
Jan W. Gratama ◽  
D. Robert Sutherland ◽  
Michael Keeney
Keyword(s):  
Progenitor Cells ◽  
Hematopoietic Stem ◽  
Flow Cytometric ◽  
Stem And Progenitor Cells
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