Future Research Opportunities in Peri-Prosthetic Joint Infection Prevention

2017 ◽  
Vol 18 (4) ◽  
pp. 409-412 ◽  
Author(s):  
Elie Berbari ◽  
John Segreti ◽  
Javad Parvizi ◽  
Sandra I. Berríos-Torres
Keyword(s):  
Prosthetic Joint Infection ◽  
Infection Prevention ◽  
Joint Infection ◽  
Future Research ◽  
Research Opportunities ◽  
Prosthetic Joint

Prosthetic Joint Infection: Prevention Update

2017 ◽  
pp. 193-246
Author(s):  
Courtney Ierano ◽  
Andrew J. Stewardson ◽  
Trisha Peel
Keyword(s):  
Prosthetic Joint Infection ◽  
Infection Prevention ◽  
Joint Infection ◽  
Prosthetic Joint

Establishing a Role for Vancomycin Powder Application for Prosthetic Joint Infection Prevention—Results of a Wear Simulation Study

2014 ◽  
Vol 29 (7) ◽  
pp. 1449-1456 ◽  
Author(s):  
Rabah Qadir ◽  
J. Lockwood Ochsner ◽  
George F. Chimento ◽  
Mark S. Meyer ◽  
Bradford Waddell ◽  
...  
Keyword(s):  
Simulation Study ◽  
Prosthetic Joint Infection ◽  
Infection Prevention ◽  
Joint Infection ◽  
Wear Simulation ◽  
Prosthetic Joint ◽  
Vancomycin Powder

scholarly journals Successful Treatment of Staphylococcus aureus Prosthetic Joint Infection with Bacteriophage Therapy

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1182
Author(s):  
Claudia Ramirez-Sanchez ◽  
Francis Gonzales ◽  
Maureen Buckley ◽  
Biswajit Biswas ◽  
Matthew Henry ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Multidrug Resistant ◽  
Successful Outcome ◽  
Prolonged Treatment ◽  
Lytic Phage ◽  
Bacteriophage Therapy ◽  
Prosthetic Joint ◽  
Knee Joint Infection

Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic joint infection occurs rarely; it is a biofilm-based infection that is poorly responsive to antibiotic alone. Recent interest in bacteriophage therapy has made it possible to treat some biofilm-based infections, as well as those caused by multidrug-resistant pathogens, successfully when conventional antibiotic therapy has failed. Here, we describe the case of a 61-year-old woman who was successfully treated after a second cycle of bacteriophage therapy administered at the time of a two-stage exchange procedure for a persistent methicillin-sensitive Staphylococcus aureus (MSSA) prosthetic knee-joint infection. We highlight the safety and efficacy of both intravenous and intra-articular infusions of bacteriophage therapy, a successful outcome with a single lytic phage, and the development of serum neutralization with prolonged treatment.

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