scholarly journals Surgical Management of Clostridium difficile Infection: The Role of Colectomy

2016 ◽  
Vol 17 (3) ◽  
pp. 343-345 ◽  
Author(s):  
Matthew J. Delano ◽  
Joseph Cuschieri
Keyword(s):  
Clostridium Difficile ◽  
Surgical Management ◽  
Clostridium Difficile Infection

scholarly journals 187 Emerging Role of Fecal Microbiota Therapy in the Treatment of Recurrent Clostridium difficile Infection in Children

2013 ◽  
Vol 144 (5) ◽  
pp. S-45
Author(s):  
Shashank Garg ◽  
W.F. Fricke ◽  
Mohit Girotra ◽  
Erik C. von Rosenvinge ◽  
Anand Dutta ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Fecal Microbiota ◽  
Recurrent Clostridium Difficile Infection

scholarly journals Prolonged Mechanical Ventilation Assistance Interacts Synergistically with Carbapenem for Clostridium difficile Infection in Critically Ill Patients

2018 ◽  
Vol 7 (8) ◽  
pp. 224 ◽  
Author(s):  
Shyh-Ren Chiang ◽  
Chih-Cheng Lai ◽  
Chung-Han Ho ◽  
Chin-Ming Chen ◽  
Chien-Ming Chao ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Clostridium Difficile ◽  
Critically Ill ◽  
Clostridium Difficile Infection ◽  
Critically Ill Patients ◽  
Prolonged Mechanical Ventilation ◽  
Comorbidity Scores ◽  
Independent Risk Factors ◽  
High Comorbidity

Objectives: Interactions between mechanical ventilation (MV) and carbapenem interventions were investigated for the risk of Clostridium difficile infection (CDI) in critically ill patients undergoing concurrent carbapenem therapy. Methods: Taiwan’s National Intensive Care Unit Database (NICUD) was used in this analytical, observational, and retrospective study. We analyzed 267,871 intubated patients in subgroups based on the duration of MV support: 7–14 days (n = 97,525), 15–21 days (n = 52,068), 22–28 days (n = 35,264), and 29–60 days (n = 70,021). The primary outcome was CDI. Results: Age (>75 years old), prolonged MV assistance (>21 days), carbapenem therapy (>15 days), and high comorbidity scores were identified as independent risk factors for developing CDI. CDI risk increased with longer MV support. The highest rate of CDI was in the MV 29–60 days subgroup (adjusted hazard ratio (AHR) = 2.85; 95% confidence interval (CI) = 1.46–5.58; p < 0.02). Moreover, higher CDI rates correlated with the interaction between MV and carbapenem interventions; these CDI risks were increased in the MV 15–21 days (AHR = 2.58; 95% CI = 1.12–5.91) and MV 29–60 days (AHR = 4.63; 95% CI = 1.14–10.03) subgroups than in the non-MV and non-carbapenem subgroups. Conclusions: Both MV support and carbapenem interventions significantly increase the risk that critically ill patients will develop CDI. Moreover, prolonged MV support and carbapenem therapy synergistically induce CDI. These findings provide new insights into the role of MV support in the development of CDI.

T2065 Curcumin Suppresses Intestinal Epithelial Response to Clostridium difficile Infection: Role of Cell Signaling Pathways

2009 ◽  
Vol 136 (5) ◽  
pp. A-631
Author(s):  
Nandakumar Srinivasan ◽  
Dharmalingam Subramaniam ◽  
Aarthi Varman ◽  
Rama P. Ramanujam ◽  
Courtney W. Houchen ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Clostridium Difficile Infection ◽  
Intestinal Epithelial ◽  
Cell Signaling Pathways

scholarly journals Physicians` awareness level assessment of the epidemiology and diagnosis features of nosocomial infection caused by Clostridium difficile in a multidisciplinary hospitals

2021 ◽  
Author(s):  
Alla Lokotkova
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Clinical Manifestations ◽  
Low Frequency ◽  
Antibiotic Use ◽  
Hospital Environment ◽  
Laboratory Diagnostics ◽  
Important Place ◽  
Lack Of Physicians

Background. Clostridium difficile has an important place among healthcare associated infections pathogens , mainly due to the widespread and inappropriate antibiotics use. Over the past 10 years an incidence of this infection has increased in the USA and European countries. Unfortunately, Clostridium difficile infection cases in the Russian Federation are almost not register, probably due to the lack of physicians awareness and underestimation of the pathogen role in the etiology of nosocomial infections. The study purpose is to study the different specialties physicians awareness of patients` Clostridium difficile infections development in multidisciplinary hospitals. Materials and methods. A questionnaire survey of 115 physicians of two multidisciplinary hospitals in Kazan was carried out. The questionnaire included 15 questions related to etiology, transmission mechanism, risk factors, clinical presentation, diagnosis and prevention of C. difficile infection. Statistical data processing was carried out in MS Excel. Results. A low level of physicians` awareness on this issue was revealed. 92.2% of physicians did not have any Clostridium difficile infection cases in their practice. 31.3% of respondents underestimate the role of antibiotic use as the main risk factor for the development of the disease; at the same time, there are frequent cases of unreasonable prescription of antibiotics. 32.2% of the respondents are poorly informed about diagnosis methods of clostridiosis. 20% of physicians deny the role of bacteria carriers as a source of infection. 77.4% of respondents indicated the alimentary route as the main route of infection transmission. Only 38.2% of respondents noted the hospital environment objects as a possible factor in the transmission of Clostridium difficile. Conclusions. There is no alertness regarding antibiotic-associated diarrhea caused by Clostridium difficile infection among multidisciplinary hospital physicians. Insufficient knowledge of epidemiology, clinical manifestations, laboratory diagnostics of Clostridium difficile infection are factors that determine the low frequency of its detection and, accordingly, impede the implementation of required anti-epidemic measures. There is a need to include Clostridium difficile infection issues in professional development programs for medical workers. It is advisable to develop and implement Clostridium difficile infection control.

Sign in / Sign up

Export Citation Format

Share Document