The Effect of Brief Exposure to Sub-Therapeutic Concentrations of Chlorhexidine Digluconate on the Susceptibility of Staphylococci to Platelet Microbicidal Protein

2015 ◽  
Vol 16 (3) ◽  
pp. 263-266 ◽  
Author(s):  
Iuri B. Ivanov ◽  
Viktor A. Gritsenko ◽  
Michael D. Kuzmin
Keyword(s):  
Chlorhexidine Digluconate ◽  
Platelet Microbicidal Protein

Characteristics of the etiological structure and susceptibility to antibiotics, antiseptics of infectious pathogens of respiratory organs in children in critical states

2018 ◽  
Vol 22 (2) ◽  
pp. 311-317
Author(s):  
O.A. Nazarchuk ◽  
A.I. Starodub ◽  
O.V. Rymsha ◽  
V.A. Starodub ◽  
S.A. Kolodii
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Agents ◽  
Inflammatory Diseases ◽  
Diffusion Method ◽  
Chlorhexidine Digluconate ◽  
Gram Positive ◽  
Critical States ◽  
Results Of Treatment ◽  
Moderate Resistance ◽  
Staphylococcus Spp

The study of the etiological structure, the properties of pathogens of the respiratory infectious diseases in children and their resistance to antibacterial agents is particularly relevant in modern conditions, expands the search for new approaches to combating pathogens, improves the results of treatment and reduces the mortality of this pathology. The aim — study of etiological structure, sensitivity to antibiotics and antiseptics of pathogens of infectious and inflammatory diseases of respiratory organs in children. In the study there were enrolled 247 patients who were treated in Vinnytsia Regional Children’s Clinical Hospital (VRCCH) in 2016. The sensitivity of microorganisms to 23 antibacterial agents was determined by the disc-diffusion method according to the generally accepted method. The analysis of the antimicrobial activity of antiseptic drugs (decamethoxine, miramistin, chlorhexidine digluconate) was performed by a double serial dilution technique with the determination of the minimum inhibitory bacteriostatic (MIC) and bactericidal (MBcC) concentrations, by the method of successive serial dilutions of the drug in a liquid nutrient medium. In patients who were in inpatient treatment at the VRCCH in 2016 because of pneumonia there were found opportunistic microorganisms which were of etiological significance in the development of the infection. Among them there were Streptococci (47,3 %), Staphylococci (15,3 %), Candida (13,3 %), Enterococci (10,9 %), including a high proportion of owned non-fermenting gram negative bacilli (9,8%) and species of Enterobacteria (2,0 %). Isolated strains of microorganisms had moderate resistance to most modern antibiotic drugs. The sensitivity of isolated strains of microorganisms to reserved antibiotics as carbapenems, often being used in the treatment of critical states of patients in the intensive care units, was found to above 18,2%. The sensitivity to this antibiotic in Enterococcus spp. (7,1 %), Staphylococcus spp. (5,9 %) was also low. Carbapenems, fluoroquinolones (the 1st and 2nd generations), antibiotics and aminoglycosides were found to be effective against gram positive microorganisms in more then 45% of cases. According to this they were considered to be as drugs of choice in the treatment of infectious and purulent-inflammatory pathology of respiratory organs, caused metitcilin- and vancomycin-resistant strains of microorganisms. Resistance to these drugs among investigated strains did not exceed 9,0 %. The high bactericidal properties of antiseptics as decamethoxine was determined against S.pyogenes, Staphylococcus spp. Its MBcC against these bacteria (1,65±0,20 mkg/ml and 4,32±0,50 mkg/ml, respectively) proved the advantage of decamethoxine’s effectiveness in comparison with chlorhexidine digluconate 3,14 times, 2,44 times miramistin. Clinical strains of C.albicans showed the highest susceptibility to decamethoxine, which fungicidal activity was determined in the presence (16,17±2,33 mkg/ml), in comparison with chlorxedine (MFtsK 27,59±3,59 mg/ml) and miramistin activity (27,59±3,595 mkg/ml). In children with inflammatory diseases of the respiratory organs gram-positive cocci are among the predominant pathogens (73,5 %) of cases, in the association allocated – 8,0 % of pathogens. Allocated strains of microorganisms were moderately resistant to all antibiotics studied. For antimicrobial activity antiseptic drugs, especially decamethoxine, have advantages over antibiotics confirming the possibility of their use in combination with systemic antibacterials.

scholarly journals The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation

2009 ◽  
Vol 137 (1-2) ◽  
pp. 6-9 ◽  
Author(s):  
Obrad Zelic ◽  
Sasa Cakic ◽  
Natalija Lukovic
Keyword(s):  
Side Effects ◽  
Oral Hygiene ◽  
Dental Plaque ◽  
De Novo ◽  
Periodontal Diseases ◽  
Experimental Period ◽  
Chlorhexidine Digluconate ◽  
Gingival Inflammation ◽  
Phenol Compound ◽  
Formation De Novo

Introduction. Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept? solution. Objective. This study evaluated the effect of Ozosept? solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP? solution (chlorhexidine digluconate). Methods. Two groups, each of 21 persons, which did not significantly differ concerning Silness-L?e plaque index (PI) and L?e-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period. Results. At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP? group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept? solution. Conclusion. It is concluded that Ozosept? solution is effective in the control of dental plaque - biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage.

scholarly journals Effect of repeated cycles of chemical disinfection in microhardness of acrylic resins of complete denture base

2017 ◽  
Vol 65 (3) ◽  
pp. 196-201
Author(s):  
Elisa das Graças MARTINS ◽  
Rafael Tobias MORETTI NETO
Keyword(s):  
Sodium Hypochlorite ◽  
Knoop Hardness ◽  
Sodium Hypochlorite Solution ◽  
Chlorhexidine Digluconate ◽  
Water Control ◽  
Denture Base ◽  
Acrylic Resins ◽  
Hardness Tests ◽  
Before And After ◽  
Edentulous Patients

ABSTRACT Objective: To evaluate the microhardness of specimens of acrylic resins VipiCril® (thermally polymerized resin) and Bosworth New Truliner® (self-polymerized resin), before and after immersion in solutions of 0.12% chlorhexidine digluconate, 1% sodium hypochlorite, Corega Tabs® and water (control), testing the null hypothesis that the mouthwashes and chemicals used to disinfect complete dentures do not interfere with the superficial microhardness, and can therefore be used as adjuncts to oral hygiene of edentulous patients. Methods: Sixty specimens of resin VipiCril®(thermally polymerized resin) and 60 specimens of resin Bosworth New Truliner® (self-polymerized resin) measuring 16 mm of diameter and 6 mm of height were prepared, which were randomly divided into four groups of 15 specimens each, undergoing Knoop hardness tests (KHN) both before and after cycles of immersion in solutions of 0.12% chlorhexidine digluconate, 1% sodium hypochlorite, Corega Tabs® and water (control). Results: The specimens of resins VipiCril and Bosworth immersed in solutions of 0.12% chlorhexidine, Corega Tabs® and water showed decreased microhardness. Conclusion: The 1% sodium hypochlorite solution caused least damage to the denture structure, not leading to decrease of the superficial microhardness.

Amphiphilic Effects of Chlorhexidine Digluconate on Rotational Mobility in Bacterial Outer Membranes and Liposomes

2021 ◽  
Vol 45 (3) ◽  
pp. 77-85
Author(s):  
Tae Young Kim ◽  
◽  
Seong-Kweon Cha ◽  
Seung-Il Eom ◽  
Moon-Kyoung Bae ◽  
...  
Keyword(s):  
Chlorhexidine Digluconate ◽  
Rotational Mobility ◽  
Outer Membranes

Comparative Evaluation of the Antimicrobial Effects of Different Mouthrinses against Streptococcus Mutans: An in Vitro Study

2019 ◽  
Vol 43 (6) ◽  
pp. 398-407
Author(s):  
Eman Abu-obaid ◽  
Fouad Salama ◽  
Ala’a Abu-obaid ◽  
Fars Alanazi ◽  
Mounir Salem ◽  
...  
Keyword(s):  
Reference Strain ◽  
In Vitro Study ◽  
Negative Control ◽  
Minimal Bactericidal Concentration ◽  
Distilled Water ◽  
Chlorhexidine Digluconate ◽  
Zone Of Inhibition ◽  
Antimicrobial Effects ◽  
Zones Of Inhibition

Purpose: To assess the antimicrobial effects of different natural and semi-natural mouthrinses on isolates of S. mutans obtained from the saliva of Saudi children and reference strains of S mutans (ATCC 25175). Study design: Saliva samples were collected from 20 children. Natural and semi-natural mouthrinses included were herbal mix mouthrinse, cranberry mouthrinse, chlorhexidine digluconate mouthrinse, cranberry extract mixed with chlorhexidine digluconate mouthrinse, chlorhexidine digluconate mouthrinse with alcohol (positive control), and distilled water (negative control). The microbiological examination tests were minimal inhibitory concentration, minimal bactericidal concentration, and zone of inhibition for the saliva isolates of S. mutans while zone of inhibition test only for reference strain of S. mutans. Results: For reference strain in a comparison with the distilled water, the herbal mix, cranberry, cranberry mixed with chlorhexidine, chlorhexidine, and chlorhexidine with alcohol showed significantly increased zones of inhibition by 36.38, 36.25, 26.13, 17.75, and 12.38, respectively. For saliva isolates in a comparison with the distilled water, the herbal mix, cranberry, cranberry mixed with chlorhexidine, chlorhexidine, and chlorhexidine with alcohol showed significantly increased zones of inhibition by 38.00, 34.25, 22.94, 16.50, and 16.44, respectively. Chlorhexidine with alcohol showed significantly lower minimum inhibitory and bactericidal concentration than the other groups. Conclusions: Herbal mix and cranberry mouthrinses could be effective natural alternative to chlorhexidine mouthrinse with or without alcohol in affecting tested parameters.

Interaction between Chlorhexidine Digluconate and EDTA

2008 ◽  
Vol 34 (12) ◽  
pp. 1521-1523 ◽  
Author(s):  
Brian J. Rasimick ◽  
Michelle Nekich ◽  
Megan M. Hladek ◽  
Barry L. Musikant ◽  
Allan S. Deutsch
Keyword(s):  
Chlorhexidine Digluconate
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